Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marije Niemeijer"'
Autor:
Shaojun Shi, Monique M.A. Verstegen, Henk P. Roest, Arif I. Ardisasmita, Wanlu Cao, Floris J.M. Roos, Petra E. de Ruiter, Marije Niemeijer, Qiuwei Pan, Jan N.M. IJzermans, Luc J.W. van der Laan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)
Background & Aims: Liver and bile duct diseases often are associated with extensive cell death of cholangiocytes. Necroptosis represents a common mode of programmed cell death in cholangiopathy, however, detailed mechanistic knowledge is limited owin
Externí odkaz:
https://doaj.org/article/2f4d610e4e7d4d40a0f49cbdf8749e04
Autor:
Muriel M Heldring, Lukas S Wijaya, Marije Niemeijer, Huan Yang, Talel Lakhal, Sylvia E Le Dévédec, Bob van de Water, Joost B Beltman
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010264 (2022)
Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as alternative to primary cells, disregarding variability. To compare DDR d
Externí odkaz:
https://doaj.org/article/bd05827ec19846e2a4c97f9f4699496c
Autor:
Deepak Mav, Dhiral P Phadke, Michele R Balik-Meisner, B Alex Merrick, Scott Auerbach, Marije Niemeijer, Suzanna Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, Bob van de Water, Ruchir R Shah, Richard S Paules
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement o
Externí odkaz:
https://doaj.org/article/d6f389cb95e54e188488ba1e4c1a51c4
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches. Here, we invest
Externí odkaz:
https://doaj.org/article/1cea0592e0d6418fa1a6419055b5bbb0
Autor:
Floris J.M. Roos, Qiuwei Pan, Petra E. de Ruiter, Jan N. M. IJzermans, Arif I. Ardisasmita, Henk P. Roest, Shaojun Shi, Monique M A Verstegen, Luc J. W. van der Laan, Marije Niemeijer, Wanlu Cao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)
Cellular and Molecular Gastroenterology and Hepatology
CMGH, 13(2), 541-564. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
CMGH, 13(2), 541-564. Elsevier Inc.
Background & Aims Liver and bile duct diseases often are associated with extensive cell death of cholangiocytes. Necroptosis represents a common mode of programmed cell death in cholangiopathy, however, detailed mechanistic knowledge is limited owing
Autor:
Samantha V. Llewellyn, Ali Kermanizadeh, Victor Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, Marije Niemeijer, Martijn J. Moné, Bob van de Water, Shambhu Roy, Wolfgang Moritz, Vicki Stone, Gareth J.S. Jenkins, Shareen H. Doak
Publikováno v:
Toxicology in Vitro
Toxicology In Vitro, 85, 105473
Toxicology In Vitro, 85, 105473
To reduce, replace, and refine in vivo testing, there is increasing emphasis on the development of more physiologically relevant in vitro test systems to improve the reliability of non-animal-based methods for hazard assessment. When developing new a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3280abd30bca97acfa6499c0f19f06ed
https://cronfa.swan.ac.uk/Record/cronfa61299
https://cronfa.swan.ac.uk/Record/cronfa61299
Autor:
Steven J. Kunnen, Marije Niemeijer, Giulia Callegaro, Laura I. Furlong, Jeffrey J. Sutherland, Janet Piñero Gonzalez, Wouter den Hollander, Panuwat Trairatphisan, Bob van de Water, Yue Webster, Emre Guney, James L. Stevens, Julio Saez-Rodriguez, Jennifer Mollon, Solène Grosdidier
Publikováno v:
Archives of Toxicology, 95(12), 3745-3775. Springer-Verlag
Archives of Toxicology
Archives of Toxicology, 95(12), 3745-3775
Archives of Toxicology
Archives of Toxicology, 95(12), 3745-3775
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing data, but interpretative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae839152101c7c0d415360667759ecf
https://pure.eur.nl/en/publications/b57c4814-0350-4abf-9941-fb822553e7c6
https://pure.eur.nl/en/publications/b57c4814-0350-4abf-9941-fb822553e7c6
Autor:
Lysiane Richert, Suzanna Huppelschoten, Bob van de Water, Marije Niemeijer, Frédéric Y. Bois, Witold Więcek, Richard S. Paules, Audrey Baze, Céline Parmentier, Peter Bouwman
Background & AimsOne of the early key events of drug-induced liver injury (DILI) is the activation of adaptive stress responses, a cellular mechanism to overcome stress. Given the diversity of DILI outcomes and lack in understanding of population var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fda617ff83e9f8251089a5361331f387
https://doi.org/10.1101/2021.08.26.457742
https://doi.org/10.1101/2021.08.26.457742
Autor:
Bob van de Water, Liesanne Wolters, Sylvia E. Le Dévédec, Bas ter Braak, Peter Bouwman, Marije Niemeijer
Publikováno v:
Mutagenesis, 37(2), 130-142
Mutagenesis
Mutagenesis
In vitro assessment of mutagenicity is an essential component in the chemical risk assessment. Given the diverse modes of action by which chemicals can induce DNA damage, it is essential that these in vitro assays are carefully evaluated for their po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c9243c6dbb2a4d056266f56a3e6873
http://hdl.handle.net/1887/3216873
http://hdl.handle.net/1887/3216873
Autor:
Emre Guney, van de Water B, Julio Saez-Rodriguez, Laura I. Furlong, Steven J. Kunnen, Mollon J, den Hollander W, Giulia Callegaro, Janet Piñero Gonzalez, Yue Webster, Panuwat Trairatphisan, James L. Stevens, Solène Grosdidier, Jeffrey J. Sutherland, Marije Niemeijer
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of comprehensive and mechanisms-revealing data, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1eb37b5fdb99fe44d4150d637b7f307
https://doi.org/10.1101/2021.05.17.444463
https://doi.org/10.1101/2021.05.17.444463