Výsledky vyhledávání - "Marije E. Otto"

Akademický článek

Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery‐Åsberg Depression Rating Scale

Autor: Marije E. Otto, Kirsten R. Bergmann, Marieke L. deKam, Kasper Recourt, Gabriël E. Jacobs, Michiel J. vanEsdonk

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1425-1436 (2023)

Abstract In clinical trials, Montgomery‐Åsberg Depression Rating Scale (MADRS) questionnaire data are added up to total scores before analysis, assuming equal contribution of each separate question. Item Response Theory (IRT)‐based analysis avoi

Externí odkaz: https://doaj.org/article/b368b3900d9748bb820769f968d0f7b2

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Akademický článek

Semimechanistic modeling of copeptin and aldosterone kinetics and dynamics in response to rehydration treatment for diabetic ketoacidosis in children

Autor: Marije E. Otto, Marie‐Anne Burckhardt, Gabor Szinnai, Marc Pfister, Verena Gotta

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 207-220 (2023)

Abstract Diabetic ketoacidosis (DKA), a frequent complication of type 1 diabetes (T1D), is characterized by hyperosmolar hypovolemia. The response of water‐regulating hormones arginine vasopressin (AVP; antidiuretic hormone) and aldosterone to DKA

Externí odkaz: https://doaj.org/article/99c58f0f7700484d8b4fa19c3d811bb6

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Semimechanistic modeling of copeptin and aldosterone kinetics and dynamics in response to rehydration treatment for diabetic ketoacidosis in children

Autor: Marije E. Otto, Marie‐Anne Burckhardt, Gabor Szinnai, Marc Pfister, Verena Gotta

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. 12:207-220

Diabetic ketoacidosis (DKA), a frequent complication of type 1 diabetes (T1D), is characterized by hyperosmolar hypovolemia. The response of water-regulating hormones arginine vasopressin (AVP; antidiuretic hormone) and aldosterone to DKA treatment i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9142a638bb5eb318495e6194f79ca3
https://doi.org/10.1002/psp4.12891

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Transcranial magnetic stimulation as biomarker of excitability in drug development: a randomized, double-blind, placebo-controlled, cross-over study

Autor: Titia Q. Ruijs, Jules A. A. C. Heuberger, Annika A. de Goede, Dimitrios Ziagkos, Marije E. Otto, Robert J. Doll, Michel J. A. M. van Putten, Geert Jan Groeneveld

Publikováno v: British Journal of Clinical Pharmacology, 88(6), 2926-2937. WILEY
British journal of clinical pharmacology, 88(6), 2926-2937. Wiley-Blackwell

Aims The purpose of this study was to investigate pharmacodynamic effects of drugs targeting cortical excitability using transcranial magnetic stimulation (TMS) combined with electromyography (EMG) and electroencephalography (EEG) in healthy subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9e0d067eecc8cbbe57969c46f9c6e9
http://hdl.handle.net/1887/3572093

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