Výsledky vyhledávání - "Marijana Sekulic-Jablanovic"

Akademický článek

Lack of NHE6 and Inhibition of NKCC1 Associated With Increased Permeability in Blood Labyrinth Barrier-Derived Endothelial Cell Layer

Autor: Marijana Sekulic-Jablanovic, Jessica Paproth, Cinzia Sgambato, Giuseppe Albano, Daniel G. Fuster, Daniel Bodmer, Vesna Petkovic

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

Acoustic trauma, autoimmune inner ear disease, and presbycusis feature loss of the integrity of the blood-labyrinth barrier (BLB). Normal BLB function depends on endothelial structural integrity, which is supported and maintained by tight junctions a

Externí odkaz: https://doaj.org/article/e8215c5589074492834fe03ca530e4d0

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Akademický článek

Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti

Autor: Marijana Sekulic-Jablanovic, Matthew B. Wright, Vesna Petkovic, Daniel Bodmer

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucia

Externí odkaz: https://doaj.org/article/b056b20e08564034b50b6ce8b0b6d177

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Akademický článek

Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress.

Autor: Marijana Sekulic-Jablanovic, Vesna Petkovic, Matthew B Wright, Krystsina Kucharava, Nathan Huerzeler, Soledad Levano, Yves Brand, Katharina Leitmeyer, Andrea Glutz, Alexander Bausch, Daniel Bodmer

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188596 (2017)

Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabe

Externí odkaz: https://doaj.org/article/0bedfaffde8b473f8375b5afaeb10bd7

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Combination of antioxidants and NFAT (nuclear factor of activated T cells) inhibitor protects auditory hair cells from ototoxic insult

Autor: Krystsina Voronkova, Marijana Sekulic-Jablanovic, Vesna Petkovic, Daniel Bodmer

Publikováno v: Journal of Neurochemistry. 154:519-529

Hair cell (HC) degeneration causes hearing loss in millions of people worldwide. Aminoglycoside exposure is one major cause of sensory HC damage. Aminoglycosides generate free radicals within the inner ear, permanently damaging sensory cells, and thu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fca495f848adce31c97a36a459942a5
https://doi.org/10.1111/jnc.14921

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Insulin Receptor and Glucose Transporters in the Mammalian Cochlea

Autor: Nathan Huerzeler, Marijana Sekulic-Jablanovic, Matthew B. Wright, Vesna Petkovic, Krystsina Kucharava, Daniel Bodmer

Publikováno v: Audiology and Neurotology. 24:65-76

Insulin receptors are expressed on nerve cells in the mammalian brain, but little is known about insulin signaling and the expression of the insulin receptor (IR) and glucose transporters in the cochlea. We performed immunohistochemistry and gene/pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4563d978801ba159fa57d0d2f9471bf2
https://doi.org/10.1159/000499561

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Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway

Autor: Daniel Guido Fuster, Xunde Xian, Vesna Petkovic, Andrea Glutz, Marijana Sekulic-Jablanovic, Giuseppe Albano, Daniel Bodmer, Yves Brand, Joachim Herz, Krystsina Kucharava

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Kucharava, Krystsina; Brand, Yves; Albano, Giuseppe; Sekulic-Jablanovic, Marijana; Glutz, Andrea; Xian, Xunde; Herz, Joachim; Bodmer, Daniel; Fuster, Daniel G.; Petkovic, Vesna (2020). Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway. Scientific reports, 10(1), p. 3609. Springer Nature 10.1038/s41598-020-60262-5

Acid-base homeostasis is critical for normal growth, development, and hearing function. The sodium–hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutati

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Extraocular muscle function is impaired in ryr3 -/- mice

Autor: Francesco Zorzato, Hiroshi Takeshima, Susan Treves, Jianjie Ma, Ki Ho Park, Marijana Sekulic-Jablanovic, Volker Enzmann, Jan Eckhardt, Christoph Bachmann

Publikováno v: Eckhardt, Jan; Bachmann, Christoph; Sekulic-Jablanovic, Marijana; Enzmann, Volker; Park, Ki Ho; Ma, Jianjie; Takeshima, Hiroshi; Zorzato, Francesco; Treves, Susan (2019). Extraocular muscle function is impaired in ryr3-/-mice. Journal of general physiology, 151(7), pp. 929-943. Rockefeller University Press 10.1085/jgp.201912333
The Journal of General Physiology

Extraocular muscles are specialized skeletal muscles expressing a particular set of proteins involved in calcium homeostasis, including RYR3. Eckhardt et al. investigate extraocular muscle function in ryr3−/− mice and show that ablation of RYR3 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efe0b95ff872013e6d9ccd56af07da7

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Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K–Akt pathway

Autor: Marijana Sekulic-Jablanovic, Krystsina Kucharava, Lukas Horvath, Vesna Petkovic, Daniel Bodmer

Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-14 (2019)

Gentamicin is a widely used antibiotic for the treatment of gram-negative bacterial infections; however, its use often results in significant and permanent hearing loss. Hearing loss resulting from hair cell (HC) degeneration affects millions of peop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e9fe47e13565d3a918c0b3d9050ac2
https://doi.org/10.1038/s41419-019-1386-7

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Pasireotide prevents nuclear factor of activated T cells nuclear translocation and acts as a protective agent in aminoglycoside-induced auditory hair cell loss

Autor: Vesna Petkovic, Daniel Bodmer, Adrijana Perkovic, Matthew B. Wright, Marijana Sekulic-Jablanovic

Publikováno v: Journal of Neurochemistry. 139:1113-1123

Hearing impairment is a global health problem with a high socioeconomic impact. Damage to auditory hair cells (HCs) in the inner ear due to aging, disease, trauma, or toxicity, underlies the majority of cases of sensorineural hearing loss. Previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001c080d2a8c96f2ee6fad31a5229974
https://doi.org/10.1111/jnc.13880

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Characterization of excitation–contraction coupling components in human extraocular muscles

Autor: Francesco Zorzato, Marijana Sekulic-Jablanovic, Anja M. Palmowski-Wolfe, Susan Treves

Publikováno v: Biochemical Journal

Excitation–contraction coupling (ECC) is the physiological mechanism whereby an electrical signal detected by the dihydropyridine receptor, is converted into an increase in [Ca2+], via activation of ryanodine receptors (RyRs). Mutations in RYR1, th

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