Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Marijan Štefinović"'
Autor:
Sandro Neuner, Thomas Gelbrich, Klaus Wurst, Josef Spreitz, Sven Nerdinger, Ulrich J. Griesser, Marijan Stefinovic, Herwig Schottenberger
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 1, Pp 24-27 (2023)
The title compound, 2,6-diamino-5-[(2-cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-yl)methyl]pyrimidin-1-ium methanesulfonate, C19H23N4O3+·CH3O3S−, is a salt made up from a protonated iclaprim molecule and a mesylate anion. The pyrimidine and chrom
Externí odkaz:
https://doaj.org/article/5bc27a2348674a28bf708c52269f20a8
Autor:
Sven Nerdinger, Marijan Stefinovic, Frank Richter, Jacek Olma, Michal Brysz, Tracy Walker, Volker Kahlenberg, Thomas Gelbrich
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 3, Pp 414-417 (2019)
In the title structure, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4(3H)-one (= idelalisib) tert-butanol monosolvate dihydrate, C22H18FN7O·C4H10O·2H2O, the idelalisib molecule displays planar quinazoline and purine systems wh
Externí odkaz:
https://doaj.org/article/79e44c478a834bdaaba3b517f1888a87
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 4, Pp 474-477 (2018)
In the salt (5α,6α)-6-[(2,5,8,11,14,17,20-heptaoxadocosan-22-yl)oxy]-3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5-epoxymorphinan-17-ium hydrogen oxalate, C34H54NO11+·C2HO4− the polyether unit of the naloxegol cation adopts the shape of a squashed open
Externí odkaz:
https://doaj.org/article/cdf060740b324eb2ba8d96c705706072
Autor:
Rhona Sinclair, Nicholas I. Pedge, Christopher J. Sleigh, James E. M. Booker, Edward Way, Marijan Štefinović, Debra Ainge, Luis-Manuel Vaz
Publikováno v:
Organic Process Research & Development. 14:72-84
The optimisation and scale up of a manufacturing route to a key intermediate, acetic acid 4-acetylamino-3-(2-methyl-oxiranylmethoxy)phenyl ester (2), utilising a SNAr coupling, the hydrogenation of a nitro moiety and the conversion of a chiral aceton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a3861bb03f5999942bc803e6b47dee
https://doi.org/10.1021/op900172t
https://doi.org/10.1021/op900172t
Publikováno v:
Magnetic Resonance in Chemistry. 45:564-571
Quality assurance and process understanding are assuming increasing importance in the production of Active Pharmaceutical Ingredients (APIs). NMR has the potential to report on physical processes, quantities, structures, and speciation as chemical re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fae0ed1ba49f7e67e6c01d5d463c9cd
https://doi.org/10.1002/mrc.2007
https://doi.org/10.1002/mrc.2007
Publikováno v:
Organic Process Research & Development. 7:198-201
A two-stage, three-step synthesis of (R)-1-hydroxy-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid from 7-methoxy tetralone is described which employed an optimised Wittig olefination of 7-methoxytetralone and Sharpless asymmetric dihydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be82f226daf9b880f836923a1f8531ea
https://doi.org/10.1021/op025590v
https://doi.org/10.1021/op025590v
Publikováno v:
ChemInform. 23
Benzopyrans can be efficiently synthesized by reacting a phenol and an allylic alcohol in a trifluoroacetic acid/water mixture under argon at room temperature. The procedure is widely applicable and allows benzopyrans to be synthesized rapidly.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::202592a64d81879509d91a172a7cef24
https://doi.org/10.1002/chin.199252190
https://doi.org/10.1002/chin.199252190
Publikováno v:
Tetrahedron Letters. 33:3795-3796
Benzopyrans can be efficiently synthesized by reacting a phenol and an allylic alcohol in a trifluoroacetic acid/water mixture under argon at room temperature. The procedure is widely applicable and allows benzopyrans to be synthesized rapidly.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::795f9bd36bc2211f8ef08c871f135617
https://doi.org/10.1016/0040-4039(92)80027-h
https://doi.org/10.1016/0040-4039(92)80027-h