Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Marija Kundakovic"'
Autor:
Devin Rocks, Ivana Jaric, Fabio Bellia, Heining Cham, John M. Greally, Masako Suzuki, Marija Kundakovic
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113187- (2023)
Summary: Early-life stress and ovarian hormones contribute to increased female vulnerability to cocaine addiction. Here, we reveal molecular substrates in the reward area, the nucleus accumbens, through which these female-specific factors affect imme
Externí odkaz:
https://doaj.org/article/b6e296708a1a4b089f80e461674c8161
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Background Ovarian hormone fluctuations over the rodent estrous cycle and the human menstrual cycle are known to significantly impact brain physiology and disease risk, yet this variable is largely ignored in preclinical neuroscience researc
Externí odkaz:
https://doaj.org/article/a3cb602d7b7b4c3b85cfaf5c8ce6f0e7
Autor:
Devin Rocks, Mamta Shukla, Laila Ouldibbat, Silvia C. Finnemann, Achyuth Kalluchi, M. Jordan Rowley, Marija Kundakovic
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors provide evidence that 3D chromatin structure in the mouse brain differs between males and females and undergoes dynamic remodelling during the female ovarian cycle. They show female-specific 3D genome dynamics affects neuronal gene e
Externí odkaz:
https://doaj.org/article/202b6f36f95a42a1a01547b4b2b59f11
Publikováno v:
Epigenetics, Vol 17, Iss 2, Pp 202-219 (2022)
The Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq) is becoming popular in the neuroscience field where chromatin regulation is thought to be involved in neurodevelopment, activity-dependent gene regulation, hormonal and environme
Externí odkaz:
https://doaj.org/article/c75be0690e9a4720b34f4ad8e2b307b0
Autor:
Ada Man-Choi Ho, Stacey J. Winham, Bryan M. McCauley, Marija Kundakovic, Keith D. Robertson, Zhifu Sun, Tamas Ordog, Lauren M. Webb, Mark A. Frye, Marin Veldic
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Rapid cycling (RC) burdens bipolar disorder (BD) patients further by causing more severe disability and increased suicidality. Because diagnosing RC can be challenging, RC patients are at risk of rapid decline due to delayed suitable treatment. Here,
Externí odkaz:
https://doaj.org/article/043abd74a9934f2b9b733de5c9728bc4
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The molecular mechanisms underlying the dynamic nature of the female brain structure and function remain poorly understood. Here the authors characterise chromatin organization in the mouse female ventral hippocampus, finding it fluctuates with the o
Externí odkaz:
https://doaj.org/article/92ea9fb336c94735871a0e1cff7dc918
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Stress during sensitive developmental periods can adversely affect physical and psychological development and contribute to later-life mental disorders. In particular, adverse experiences during childhood dramatically increase the risk for the develo
Externí odkaz:
https://doaj.org/article/c8010afdad644deab5116230e09dd077
Autor:
Kiran, Girdhar, Gabriel E, Hoffman, Jaroslav, Bendl, Samir, Rahman, Pengfei, Dong, Will, Liao, Mads E, Hauberg, Laura, Sloofman, Leanne, Brown, Olivia, Devillers, Bibi S, Kassim, Jennifer R, Wiseman, Royce, Park, Elizabeth, Zharovsky, Rivky, Jacobov, Elie, Flatow, Alexey, Kozlenkov, Thomas, Gilgenast, Jessica S, Johnson, Lizette, Couto, Mette A, Peters, Jennifer E, Phillips-Cremins, Chang-Gyu, Hahn, Raquel E, Gur, Carol A, Tamminga, David A, Lewis, Vahram, Haroutunian, Stella, Dracheva, Barbara K, Lipska, Stefano, Marenco, Marija, Kundakovic, John F, Fullard, Yan, Jiang, Panos, Roussos, Schahram, Akbarian
Publikováno v:
Girdhar, K, Hoffman, G E, Bendl, J, Rahman, S, Dong, P, Liao, W, Hauberg, M E, Sloofman, L, Brown, L, Devillers, O, Kassim, B S, Wiseman, J R, Park, R, Zharovsky, E, Jacobov, R, Flatow, E, Kozlenkov, A, Gilgenast, T, Johnson, J S, Couto, L, Peters, M A, Phillips-Cremins, J E, Hahn, C G, Gur, R E, Tamminga, C A, Lewis, D A, Haroutunian, V, Dracheva, S, Lipska, B K, Marenco, S, Kundakovic, M, Fullard, J F, Jiang, Y, Roussos, P, Akbarian, S & PsychENCODE Consortium 2022, ' Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains ', Nature Neuroscience, vol. 25, no. 4, pp. 474-483 . https://doi.org/10.1038/s41593-022-01032-6
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In th
Autor:
Marija Kundakovic, Devin Rocks
Publikováno v:
Journal of neuroendocrinologyREFERENCES.
The activity of neurons in the rodent hippocampus contributes to diverse behaviors, with the activity of ventral hippocampal neurons affecting behaviors related to anxiety and emotion regulation, and the activity of dorsal hippocampal neurons affecti
Autor:
Marija Kundakovic
Publikováno v:
Trends in Neurosciences. 45:716-717
In a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal