Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mariia Radaeva"'
Publikováno v:
PAIN Reports, Vol 9, Iss 2, p e1119 (2024)
Abstract. Introduction:. Primary chronic pain is pain that persists for over 3 months without associated measurable tissue damage. One of the most consistent findings in primary chronic pain is its association with autonomic hyperactivation. Yet whet
Externí odkaz:
https://doaj.org/article/61cefa4049f14214acba9f94e8b1fd87
Autor:
Mariia Radaeva, Huifang Li, Eric LeBlanc, Kush Dalal, Fuqiang Ban, Fabrice Ciesielski, Bonny Chow, Helene Morin, Shannon Awrey, Kriti Singh, Paul S. Rennie, Nada Lallous, Artem Cherkasov
Publikováno v:
Cells, Vol 11, Iss 18, p 2785 (2022)
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androgen receptor (AR) represents a major challenge for the treatment of prostate cancer patients. To address this challenge, we have developed a novel clas
Externí odkaz:
https://doaj.org/article/4aa1ebf257e04f9f8d6c4c6190d87376
Autor:
Mohit Pandey, Mariia Radaeva, Hazem Mslati, Olivia Garland, Michael Fernandez, Martin Ester, Artem Cherkasov
Publikováno v:
Molecules, Vol 27, Iss 16, p 5114 (2022)
Computational prediction of ligand–target interactions is a crucial part of modern drug discovery as it helps to bypass high costs and labor demands of in vitro and in vivo screening. As the wealth of bioactivity data accumulates, it provides oppor
Externí odkaz:
https://doaj.org/article/f60c71814bfc4a21be54e803f827c010
Autor:
Victor M. Matias-Barrios, Mariia Radaeva, Yi Song, Zaccary Alperstein, Ahn R. Lee, Veronika Schmitt, Joseph Lee, Fuqiang Ban, Ning Xie, Jianfei Qi, Nada Lallous, Martin E. Gleave, Artem Cherkasov, Xuesen Dong
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In
Externí odkaz:
https://doaj.org/article/e540c6f93470479eae4a4308cd7ca9c6
Autor:
Mariia Radaeva, Fuqiang Ban, Fan Zhang, Eric LeBlanc, Nada Lallous, Paul S. Rennie, Martin E. Gleave, Artem Cherkasov
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2493 (2021)
The inhibition of the androgen receptor (AR) is an established strategy in prostate cancer (PCa) treatment until drug resistance develops either through mutations in the ligand-binding domain (LBD) portion of the receptor or its deletion. We previous
Externí odkaz:
https://doaj.org/article/010b931fe430490e8c399bcf1c17b454
Autor:
Mariia Radaeva, Helene Morin, Mohit Pandey, Fuqiang Ban, Maria Guo, Eric LeBlanc, Nada Lallous, Artem Cherkasov
Publikováno v:
Molecular Informatics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c7bf0aa76ae26ee94212493c7931c7
https://doi.org/10.1002/minf.202300026
https://doi.org/10.1002/minf.202300026
Publikováno v:
Machine Learning and Deep Learning in Computational Toxicology ISBN: 9783031207297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac65d62a1b48a8428bacc8b28edd8ad7
https://doi.org/10.1007/978-3-031-20730-3_25
https://doi.org/10.1007/978-3-031-20730-3_25
Publikováno v:
Database. 2023
The isolation of proteins of interest from cell lysates is an integral step to study protein structure and function. Liquid chromatography is a technique commonly used for protein purification, where the separation is performed by exploiting the diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb0bd110227b1a790aadd7e938450d4
https://doi.org/10.1093/database/baad016
https://doi.org/10.1093/database/baad016
Publikováno v:
Drug Discovery Today. 26:2660-2679
Transcription factors (TFs) act as major oncodrivers in many cancers and are frequently regarded as high-value therapeutic targets. The functionality of TFs relies on direct protein-DNA interactions, which are notoriously difficult to target with sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8f9e915881ba0c75eda0284323e403
https://doi.org/10.1016/j.drudis.2021.07.018
https://doi.org/10.1016/j.drudis.2021.07.018
Autor:
Artem Cherkasov, Dustin T. King, Natalie C. J. Strynadka, Som S. Chatterjee, J. Andrew N. Alexander, Mariia Radaeva, Henry F. Chambers
Publikováno v:
Journal of Biological Chemistry. 295:10870-10884
Methicillin-resistant Staphylococcus aureus (MRSA) infections cause significant mortality and morbidity globally. MRSA resistance to β-lactam antibiotics is mediated by two divergons that control levels of a β-lactamase, PC1, and a penicillin-bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4810b357e0162a1169d4102bc1b5be8
https://doi.org/10.1074/jbc.ra120.013029
https://doi.org/10.1074/jbc.ra120.013029