Chemically modified glycogens: how they influence formation of amyloid fibrils?

Autor: Petr Štěpánek, Lenka Loukotová, Jiřina Hromádková, Zdislava Pechrová, Monika Holubova, Martin Hrubý, Olga Trhlíková, Mariia Rabyk, Volodymyr Lobaz, Ondřej Groborz

Publikováno v: Soft Matter. 17:1614-1627

The formation of amyloid fibrils from certain proteins stays behind a number of pathologies, so-called amyloidoses. Glycosaminoglycans are polysaccharides and are known natural constituents of amyloids in vivo. However, little is known about the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dc62e17cb5d4feecb71e2971c38ea9
https://doi.org/10.1039/d0sm01829e

Does polysaccharide glycogen behave as a promoter of amyloid fibril formation at physiologically relevant concentrations?

Autor: Ondřej Groborz, Olga Trhlíková, Monika Holubova, Zdislava Pechrová, Mariia Rabyk, Jiřina Hromádková, Volodymyr Lobaz, Lenka Loukotová, Petr Štěpánek, Martin Hrubý

Publikováno v: Soft Matter. 17:1628-1641

We investigated the influence of glycogen (GG), phytoglycogen (PG), mannan (MAN) and cinnamoyl-modified GG (GG-CIN) on amyloid fibril formation. We used hen egg-white lysozyme (HEWL) as a model system and amyloid beta peptide (1-42) (Aβ1-42) as an A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1419af43e2a23276ddcef54c7a304c75
https://doi.org/10.1039/d0sm01884h

Glycogen as an advantageous polymer carrier in cancer theranostics: Straightforward in vivo evidence

Autor: Milan Hájek, Daniel Jirak, Andrea Gálisová, Markéta Jirátová, Eva Sticova, Mariia Rabyk, Martin Hrubý

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

As a natural polysaccharide polymer, glycogen possesses suitable properties for use as a nanoparticle carrier in cancer theranostics. Not only it is inherently biocompatible, it can also be easily chemically modified with various moieties. Synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3397e7aa086251e31499973df7b3dcd7
https://pubmed.ncbi.nlm.nih.gov/32591567

Thermoresponsive β-glucan-based polymers for bimodal immunoradiotherapy – Are they able to promote the immune system?

Autor: Luděk Šefc, Lenka Loukotová, Olga Janoušková, Věra Kolářová, Jan Kučka, Mariia Rabyk, Kristýna Venclíková, Petr Štěpánek, Tomáš Heizer, Anita Höcherl, Martin Hrubý, Petr Páral

Publikováno v: Journal of Controlled Release. 268:78-91

A conceptually new bimodal immunoradiotherapy treatment was demonstrated using thermoresponsive polymer β-glucan-graft-poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline) bearing complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06879bf20de6c439b63ca4f635faaaf8
https://doi.org/10.1016/j.jconrel.2017.10.010

Interplay of Thermosensitivity and pH Sensitivity of Amphiphilic Block–Gradient Copolymers of Dimethylaminoethyl Acrylate and Styrene

Autor: Laurent Billon, Alain Lapp, Petr Stepanek, Martin Hruby, Aurélie Destephen, Oleg V. Borisov, Stephen M. King, Laurence Noirez, Elise Deniau, Mariia Rabyk

Publikováno v: Macromolecules
Macromolecules, American Chemical Society, 2018, 51 (14), pp.5219-5233. ⟨10.1021/acs.macromol.8b00621⟩
Macromolecules, 2018, 51 (14), pp.5219-5233. ⟨10.1021/acs.macromol.8b00621⟩

International audience; ovel pH- and thermoresponsive amphiphilic diblock copolymer, comprising hydrophilic poly(2-dimethylaminoethyl acrylate) (PDMAEA) and amphiphilic poly(styrene-grad-2-dimethylaminoethyl acrylate) (P(S-grad-DMAEA)) blocks, was sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65feb55a80bca564762c7e6012197b59
https://hal.archives-ouvertes.fr/hal-01860230