Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection.

Autor: Florence Robert-Gangneux, Anne-Sophie Drogoul, Octavie Rostan, Claire Piquet-Pellorce, Jérome Cayon, Mariette Lisbonne, André Herbelin, Hugues Gascan, Claude Guiguen, Michel Samson, Jean-Pierre Gangneux

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33413 (2012)

The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantit

Externí odkaz: https://doaj.org/article/5b6383e8b2a6453d9da71da97c2b2030

Interleukin-33 overexpression is associated with liver fibrosis in mice and humans

Autor: Annie L'Helgoualc'h, Mariette Lisbonne, Hugues Gascan, Michel Rauch, Katia Bourd-Boittin, Nathalie Théret, Bruno Turlin, Claire Piquet-Pellorce, Michel Samson, Pierrick Marvie, Laurence Preisser

Publikováno v: Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, Wiley Open Access, 2010, 14 (6B), pp.1726-39. ⟨10.1111/j.1582-4934.2009.00801.x⟩
Journal of Cellular and Molecular Medicine, 2010, 14 (6B), pp.1726-39. ⟨10.1111/j.1582-4934.2009.00801.x⟩

International audience; Interleukin-33 (IL-33), the most recently identified member of the IL-1 family, induces synthesis of T Helper 2 (Th2)-type cytokines via its heterodimeric ST2/IL-1RAcP receptor. Th2-type cytokines play an important role in fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086df8539c7c19aa7e9779d113e42dd
https://doi.org/10.1111/j.1582-4934.2009.00801.x

TLR-Dependent IL-4 Production by Invariant Vα14+Jα18+ NKT Cells to Initiate Contact Sensitivity In Vivo

Autor: Maria Leite-de-Moraes, Marian Szczepanik, Philip W. Askenase, Atsuko Itakura, Sukit Roongapinun, Mariette Lisbonne, Daniel R. Goldstein

Publikováno v: The Journal of Immunology. 175:6390-6401

LPS stimulated B-1 cell polyclonal in vivo IgM responses depend on IL-4 release by invariant Vα14+Jα18+ NKT (iNKT) cells. The IgM Abs can recruit effector T cells to mediate contact sensitivity. LPS activates the B-1 cell response just 1 day later,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c94737f705110fb630cf268238abe8e
https://doi.org/10.4049/jimmunol.175.10.6390

Characterization of the components of urban particulate matter mediating impairment of nitric oxide-dependent relaxation in intrapulmonary arteries

Autor: Arnaud, Courtois, Caroline, Prouillac, Isabelle, Baudrimont, Céline, Ohayon-Courtes, Véronique, Freund-Michel, Mathilde, Dubois, Mariette, Lisbonne-Autissier, Roger, Marthan, Jean-Pierre, Savineau, Bernard, Muller

Publikováno v: Journal of applied toxicology : JAT. 34(6)

We have previously shown that exposure to urban particulate matter (UPM) impairs endothelial nitric oxide (NO) bioactivity in intrapulmonary arteries. As UPM is composed of heterogeneous constituents, the aim of this study was to clarify the class of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a59ffd50690481c11fb0f531b5d8f367
https://pubmed.ncbi.nlm.nih.gov/23881823

Interleukin-4-dependent innate collaboration between iNKT cells and B-1 B cells controls adaptative contact sensitivity

Autor: Marian Szczepanik, Mariette Lisbonne, Maria Leite-de-Moraes, Atsuko Itakura, Neelendu Dey, Regis A. Campos, Philip W. Askenase

We showed that hepatic Valpha14+ invariant natural killer T (iNKT) cells, via their rapid interleukin (IL)-4 production, activate B-1 cells to initiate contact sensitivity (CS). This innate collaboration was absent in IL-4(-/-) and signal transducer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84805ff5b4b6bdc101ca6f799b5995b8
https://europepmc.org/articles/PMC1782258/