A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

Autor: Michaela Wenzel, Marien P. Dekker, Biwen Wang, Maroeska J. Burggraaf, Wilbert Bitter, Jan R. T. van Weering, Leendert W. Hamoen

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions an

Externí odkaz: https://doaj.org/article/6891a8b700bc4b0d86ca8c303d7203c1

VPS35 depletion does not impair presynaptic structure and function

Autor: Jan R.T. van Weering, Sonia Vazquez-Sanchez, Sander Bobeldijk, Marien P. Dekker, Linda van Keimpema

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, 8(1):2996. Nature Publishing Group
Scientific Reports, 8(1):2996, 1-12. Nature Publishing Group
Vazquez-Sanchez, S, Bobeldijk, S, Dekker, M P, van Keimpema, L & van Weering, J R T 2018, ' VPS35 depletion does not impair presynaptic structure and function ', Scientific Reports, vol. 8, no. 1, 2996 . https://doi.org/10.1038/s41598-018-20448-4
Scientific Reports
Vazquez-Sanchez, S, Bobeldijk, S, Dekker, M P, Van Keimpema, L & Van Weering, J R T 2018, ' VPS35 depletion does not impair presynaptic structure and function ', Scientific Reports, vol. 8, no. 1, 2996, pp. 1-12 . https://doi.org/10.1038/s41598-018-20448-4

The endosomal system is proposed as a mediator of synaptic vesicle recycling, but the molecular recycling mechanism remains largely unknown. Retromer is a key protein complex which mediates endosomal recycling in eukaryotic cells, including neurons.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8764441d1872145454e62b024b6da
http://link.springer.com/article/10.1038/s41598-018-20448-4

The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity

Autor: Supayang Piyawan Voravuthikunchai, Varomyalin Tipmanee, Leendert W. Hamoen, Dennapa Saeloh, Michaela Wenzel, Wilbert Bitter, Kin Ki Jim, Marien P. Dekker

Publikováno v: PLoS Pathogens, 14(2):e1006876. Public Library of Science
Plos Pathogens, 14(2):e1006876. Public Library of Science
PLoS Pathogens, Vol 14, Iss 2, p e1006876 (2018)
Saeloh, D, Tipmanee, V, Jim, K K, Dekker, M P, Bitter, W, Voravuthikunchai, S P, Wenzel, M & Hamoen, L W 2018, ' The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity ', Plos Pathogens, vol. 14, no. 2, e1006876 . https://doi.org/10.1371/journal.ppat.1006876
Saeloh, D, Tipmanee, V, Jim, K K, Dekker, M P, Bitter, W, Voravuthikunchai, S P, Wenzel, M & Hamoen, L W 2018, ' The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity ', PLoS Pathogens, vol. 14, no. 2, e1006876 . https://doi.org/10.1371/journal.ppat.1006876
PLoS Pathogens

The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce6bcd367c08c34cb6382720797ed5c
https://doi.org/10.1371/journal.ppat.1006876

Megalencephalic leukoencephalopathy with cysts: the Glialcam-null mouse model

Autor: Truus E.M. Abbink, Timo J. ter Braak, Marien P. Dekker, Marjo S. van der Knaap, Marjolein Breur, Ursula Boschert, Nienke L. Postma, Rogier Min, Jan R.T. van Weering, Marianna Bugiani, Mohit Dubey, Huibert D. Mansvelder

Publikováno v: Annals of Clinical and Translational Neurology, 4(7), 450-465. John Wiley and Sons Ltd
Bugiani, M, Dubey, M, Breur, M, Postma, N L, Dekker, M P, Ter Braak, T, Boschert, U, Abbink, T E M, Mansvelder, H D, Min, R, van Weering, J R T & van der Knaap, M S 2017, ' Megalencephalic leukoencephalopathy with cysts : the Glialcam-null mouse model ', Annals of Clinical and Translational Neurology, vol. 4, no. 7, pp. 450-465 . https://doi.org/10.1002/acn3.405
Annals of Clinical and Translational Neurology

OBJECTIVE: Megalencephalic leukoencephalopathy with cysts (MLC) is a genetic infantile-onset disease characterized by macrocephaly and white matter edema due to loss of MLC1 function. Recessive mutations in either MLC1 or GLIALCAM cause the disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18da0debc0116b0f335ebb3521d7223b
https://research.vu.nl/en/publications/b02cdf3a-347e-47ff-b863-2f4203dbb7ea