Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Marien J C, Houtman"'
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Akademický článek
Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome
Autor: Marien J. C. Houtman, Theres Friesacher, Xingyu Chen, Eva-Maria Zangerl-Plessl, Marcel A. G. van der Heyden, Anna Stary-Weinzinger
Publikováno v: Frontiers in Pharmacology, Vol 12 (2022)
Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channe
Externí odkaz: https://doaj.org/article/f720fead0f634b2e88a84576c7772e8d
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2
Akademický článek
PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression
Autor: Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger, Marcel A. G. van der Heyden
Publikováno v: Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-10 (2017)
Abstract Background The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate with increased IK1
Externí odkaz: https://doaj.org/article/efbd78c2599d487c96e896e9cb6f2763
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3
Akademický článek
Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification
Autor: Muge Qile, Yuan Ji, Marien J. C. Houtman, Marlieke Veldhuis, Fee Romunde, Bart Kok, Marcel A. G. van der Heyden
Publikováno v: Frontiers in Physiology, Vol 10 (2019)
KIR2.1 potassium channels, producing inward rectifier potassium current (IK1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. Abnormal KIR2.1 function, either de
Externí odkaz: https://doaj.org/article/4879b9edd99e4745970180a8414bb651
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4
Akademický článek
Computational Identification of Novel Kir6 Channel Inhibitors
Autor: Xingyu Chen, Arthur Garon, Marcus Wieder, Marien J. C. Houtman, Eva-Maria Zangerl-Plessl, Thierry Langer, Marcel A. G. van der Heyden, Anna Stary-Weinzinger
Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)
KATP channels consist of four Kir6.x pore–forming subunits and four regulatory sulfonylurea receptor (SUR) subunits. These channels couple the metabolic state of the cell to membrane excitability and play a key role in physiological processes such
Externí odkaz: https://doaj.org/article/aa05dd91a1274bf398cbe231dc7803e6
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5
Glibenclamide and HMR1098 normalize Cantú syndrome‐associated gain‐of‐function currents
Autor: Muge Qile, Gijs van Haaften, Anna Stary-Weinzinger, Karen Duran, Marcel A.G. van der Heyden, Marien J C Houtman, Xingyu Chen
Publikováno v: Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, 23(8), 4962. Wiley-Blackwell
Cantú syndrome (CS) is caused by dominant gain‐of‐function mutation in ATP‐dependent potassium channels. Cellular ATP concentrations regulate potassium current thereby coupling energy status with membrane excitability. No specific pharmacother
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10653c6322dd2bb1123bd7e73ec43149
http://europepmc.org/articles/PMC7346732
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6
LUF7244 plus Dofetilide Rescues Aberrant Kv11.1 Trafficking and Produces Functional IKv11.1
Autor: Doreth Fransen, Brian P. Delisle, Ad P. Ijzerman, Willem B. van Ham, Yuan Ji, Craig T. January, Tyona D. Golden, Anna Stary-Weinzinger, Laura H. Heitman, Muge Qile, Marien J C Houtman, Marcel A.G. van der Heyden, Fee Romunde
Publikováno v: Molecular Pharmacology, 97(6), 355-364
Kv11.1 (hERG) channels play a critical role in repolarization of cardiomyocytes during the cardiac action potential (AP). Drug mediated Kv11.1 blockade results in AP prolongation, which poses an increased risk of sudden cardiac death. Many drugs, lik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f19409ef10ac6ca1a07fb97b8399be9
http://hdl.handle.net/1887/3200949
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8
Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog
Autor: Rosanne Varkevisser, Marien J C Houtman, Henriette D.M. Beekman, Marc A. Vos, Alexandre Bossu, Marcel A.G. van der Heyden
Publikováno v: Journal of Cardiovascular Pharmacology
Journal of Cardiovascular Pharmacology, 69(6), 398. Lippincott Williams and Wilkins
Supplemental Digital Content is Available in the Text.
Short-term variability (STV), to quantify beat-to-beat variability of repolarization, is a surrogate parameter that reliably identifies proarrhythmic risk in preclinical models. Examples inc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add9eccaf2a946be03cab2a7a60dea14
http://europepmc.org/articles/PMC5464753
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10
Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification
Autor: Bart Kok, Marlieke G. Veldhuis, Marien J C Houtman, Fee Romunde, Yuan Ji, Marcel A.G. van der Heyden, Muge Qile
Publikováno v: Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology, 10(JUL). Frontiers Research Foundation
K IR2.1 potassium channels, producing inward rectifier potassium current (I K1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. Abnormal K IR2.1 function, either
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28644186d9318522dce90156e7e38ddf
https://dspace.library.uu.nl/handle/1874/387120
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