The first exome wide association study in Tunisia: identification of candidate loci and pathways with biological relevance for type 2 diabetes

Autor: Hamza Dallali, Wided Boukhalfa, Nadia Kheriji, Meriem Fassatoui, Haifa Jmel, Meriem Hechmi, Ismail Gouiza, Mariem Gharbi, Wafa Kammoun, Mehdi Mrad, Marouen Taoueb, Asma Krir, Hajer Trabelsi, Afef Bahlous, Henda Jamoussi, Olfa Messaoud, Abdelmajid Abid, Rym Kefi

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionType 2 diabetes (T2D) is a multifactorial disease involving genetic and environmental components. Several genome-wide association studies (GWAS) have been conducted to decipher potential genetic aberrations promoting the onset of this met

Externí odkaz: https://doaj.org/article/ec2f2977e6d94ae5b458346728bffc4e

Genetic characterization of suspected MODY patients in Tunisia by targeted next-generation sequencing

Autor: Sonia Abdelhak, Henda Jamoussi, Melika Ben Ahmed, Mariem Gharbi, Haifa Jmel, Abdelmajid Abid, Federica Alberico, Om Kalthoum Sallem, Afaf Bahlous, Hamza Dallali, Rym Kefi, Tommaso Mazza, Serena Pezzilli, Sahar Elouej, Luana Mercuri, Yosra Ben Halima, Mariem Chargui, Sabrina Prudente, Meriem Hechmi, Vincenzo Trischitta

Publikováno v: Acta Diabetologica
Acta Diabetologica, 2019, 56 (5), pp.515-523. ⟨10.1007/s00592-018-01283-5⟩
Acta Diabetologica, Springer Verlag, 2019, 56 (5), pp.515-523. ⟨10.1007/s00592-018-01283-5⟩

International audience; AIMS: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes with autosomal dominant inheritance pattern. The diagnosis of MODY and its subtypes is based on genetic testing. Our aim was investigating MODY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2168dd90519576e6dd8b4042df9e732
https://pubmed.ncbi.nlm.nih.gov/30656436