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pro vyhledávání: '"Marielle Walraven"'
Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
Autor:
Marielle Walraven, Boris Hinz
Publikováno v:
Matrix Biology. :205-224
Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular matrix (ECM) and represents the final stage of several life-threatening diseases. The progressive replacement of normal tissue by fibrotic ECM impedes organ f
Autor:
Monika Lodyga, Abby L. Olsen, Marielle Walraven, Rebecca G. Wells, Stellar Boo, Michelle Im, Grace Chau, Eric S. White, Boris Hinz, Anne Koehler, Franco Klingberg, Melissa L. Chow
Publikováno v:
Journal of Cell Science.
Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate disordered and stiff extracellular matrix (ECM) leading to fibrosis. Fibronectin immobilizes latent TGF-β-binding protein-1 (LTBP-1) and thus stor