Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marielle Paris"'
Publikováno v:
Expert Opinion on Therapeutic Patents. 19:919-941
For20 years, pharmaceutical companies and academic centers have been developing bradykinin antagonists. The patent literature on these molecules (up to and including 2004) has been analyzed previously in this journal in two review articles.The aim of
Publikováno v:
Journal of Medicinal Chemistry. 51:1505-1529
Autor:
Sandro Giuliani, Cristina Rossi, Valerio Caciagli, Laura Quartara, Rossano Nannicini, Stefania Meini, Alessandro Bressan, Daniela Fattori, Christopher I. Fincham, Fernando Catrambone, Piero D’Andrea, Elena Marastoni, Carlo Alberto Maggi, Claudio Valenti, Rosa Terracciano, Martina Gensini, Patrizia Felicetti, Marielle Paris
Publikováno v:
Journal of Medicinal Chemistry. 50:550-565
Recently we reported on the design and synthesis of a novel class of selective nonpeptide bradykinin (BK) B2 receptor antagonists (J. Med. Chem. 2006, 3602-3613). This work led to the discovery of MEN 15442, an antagonist with subnanomolar affinity f
Autor:
Sandra Bartoli, Amalia Cipollone, Mario Bigioni, Marco Berettoni, Alessandro Ettorre, Carlo Alberto Maggi, Christopher I. Fincham, Federica Nardelli, Marina Porcelloni, Daniela Fattori, Paola Paoli, Patrizia Rossi, Monica Binaschi, Sandro Mauro, Marielle Paris, Elena Marastoni, Massimo Parlani
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(7)
In the search for a new class of histone deacetylase inhibitors, we prepared a series of very simple benzofused hydroxamic acids to find an anchoring fragment of minimal molecular weight: they showed very good ligand efficiencies. Following these fin
Autor:
Annie Heitz, Jean-Alain Fehrentz, William Gibbons, Jean Martinez, Marielle Paris, Céline Douat
Publikováno v:
Tetrahedron Letters
Tetrahedron Letters, Elsevier, 1999, 40, pp.5179-5182. ⟨10.1016/S0040-4039(99)00874-6⟩
Tetrahedron Letters, Elsevier, 1999, 40, pp.5179-5182. ⟨10.1016/S0040-4039(99)00874-6⟩
A methodology to modify aspartyl or glutamyl residue side-chains after their incorporation on solid phase synthesis in a peptide sequence was developed. This strategy using the concept of Weinreb amide on the side chain of aspartyl or glutamyl residu
Autor:
Jean-Alain Fehrentz, Jean Martinez, Annie Heitz, Vincent Guerlavais, Michèle Cristau, Marielle Paris
Publikováno v:
Tetrahedron Letters. 39:7287-7290
A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected α-amino aldehyde with MBHA-supported Wittig ou Wittig-Horner reagent yielded resin-linked α-β-unsaturated δ-amino derivative. After elo
Publikováno v:
Tetrahedron Letters
Tetrahedron Letters, Elsevier, 1998, 39, pp.1341-1344
Tetrahedron Letters, Elsevier, 1998, 39, pp.1341-1344
The reduction of Weinreb amides was reinvestigated in order to find conditions that will allow the synthesis of protected aspartyl and glutamyl aldehydes derivatives useful for peptide and pseudopeptide syntheses. We have demonstrated that lithium tr
Publikováno v:
Tetrahedron Letters. 39:1569-1572
N-protected α-alkyl-γ-amino-β-keto-esters were synthesized from the corresponding N-urethane protected N-carboxyanhydride (UNCAs) by reaction with lithium enolates in fairly good yields. These compounds are candidates for mimicking the transition
Autor:
Francois Winternitz, Annie Heitz, Jiri Velek, Jean Martinez, Jean-Alain Fehrentz, Marielle Paris
Publikováno v:
Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 1997, 62 (20), pp.6792-6796
Journal of Organic Chemistry, American Chemical Society, 1997, 62 (20), pp.6792-6796
Peptides with C-terminal aldehydes (PAs) are of interest due to their inhibitory properties toward numerous classes of proteolytic enzymes. In this paper, we describe and compare two novel approaches for the preparation of PAs by solid phase synthesi
Autor:
Sandro Mauro, Daniela Fattori, Alessandro Ettorre, Sandra Bartoli, Christopher I. Fincham, Massimo Parlani, Carlo Alberto Maggi, Marina Porcelloni, Federica Nardelli, Elena Marastoni, Amalia Cipollone, Monica Binaschi, Marielle Paris, Mario Bigioni, Marco Berettoni
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(14)
In the search for a new class of histone deacetylase inhibitors, we prepared a series of simple benzofused hydroxamic acids to find an anchoring fragment of minimal molecular weight. These initial hits, all belonging to the benzothiophene class, show