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pro vyhledávání: '"Marielle Huot"'
Autor:
Marielle Huot, Chantal Richer, Rahinatou Djibo, Rafael Najmanovich, Daniel Sinnett, Noël J.-M. Raynal, Maxime Caron, Pascal St-Onge
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:845-856
Embryonal rhabdomyosarcoma (eRMS) is the most common type of rhabdomyosarcoma in children. eRMS is characterized by malignant skeletal muscle cells driven by hyperactivation of several oncogenic pathways including the MYC pathway. Targeting MYC in ca
Publikováno v:
Cancer Research. 82:B041-B041
The drug discovery process in oncology relies mainly on screening and preclinical validation platforms that use human cancer cells that are grown in standard monolayer (2D) cultures. However, 2D monolayer cell culture methods poorly reflect the tumor