Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Marielle E. Yohe"'
Autor:
Stacey Stauffer, Jacob S. Roth, Edjay R. Hernandez, Joshua T. Kowalczyk, Nancy E. Sealover, Katie E. Hebron, Amy James, Kristine A. Isanogle, Lisa A. Riffle, Lilia Ileva, Xiaoling Luo, Jin-Qiu Chen, Noemi Kedei, Robert L. Kortum, Haiyan Lei, Jack F. Shern, Joseph D. Kalen, Elijah F. Edmondson, Matthew D. Hall, Simone Difilippantonio, Carol J. Thiele, Marielle E. Yohe
Publikováno v:
Cancers, Vol 16, Iss 13, p 2320 (2024)
Activating mutations in the RAS/MAPK pathway are observed in relapsed neuroblastoma. Preclinical studies indicate that these tumors have an increased sensitivity to inhibitors of the RAS/MAPK pathway, such as MEK inhibitors. MEK inhibitors do not ind
Externí odkaz:
https://doaj.org/article/6aa231f7d2064697bf39a93b7ac6369e
Autor:
Silvia Pomella, Prethish Sreenivas, Berkley E. Gryder, Long Wang, David Milewski, Matteo Cassandri, Kunal Baxi, Nicole R. Hensch, Elena Carcarino, Young Song, Hsien-Chao Chou, Marielle E. Yohe, Benjamin Z. Stanton, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y. Chen, Peter Houghton, Javed Khan, Rossella Rota, Myron S. Ignatius
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super e
Externí odkaz:
https://doaj.org/article/13792164b2674112a670f2c8b5793e7e
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 2 (2022)
The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous syndrome, Costello syn
Externí odkaz:
https://doaj.org/article/499ee81276df40caa1190455b8675e76
Autor:
Zhihui Liu, Xiyuan Zhang, Haiyan Lei, Norris Lam, Sakereh Carter, Oliver Yockey, Max Xu, Arnulfo Mendoza, Edjay R. Hernandez, Jun S. Wei, Javed Khan, Marielle E. Yohe, Jack F. Shern, Carol J. Thiele
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer with impaired myogenic differentiation despite the presence of myogenic transcription factors. Here, the authors show that CASZ1 directly regulates these myogenic factors and the loss of CASZ1 i
Externí odkaz:
https://doaj.org/article/97d6c3168b084c6fbf5af342e06696ec
Autor:
Berkley E. Gryder, Lei Wu, Girma M. Woldemichael, Silvia Pomella, Taylor R. Quinn, Paul M. C. Park, Abigail Cleveland, Benjamin Z. Stanton, Young Song, Rossella Rota, Olaf Wiest, Marielle E. Yohe, Jack F. Shern, Jun Qi, Javed Khan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Core regulatory transcription factors are usually regulated by cell-type specific super enhancers (SEs). Here, the authors screen for chemical probes able to distinguish between SE-driven and promoter-driven transcription and find that histone deacet
Externí odkaz:
https://doaj.org/article/742c055d88f34a9a94fff834255a1649
Publikováno v:
American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 190:541-560
The RASopathies are a group of clinically defined developmental syndromes caused by germline variants of the RAS/mitogen-activated protein (MAPK) cascade. The prototypic RASopathy is Noonan syndrome, which has phenotypic overlap with related disorder
Autor:
Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, Marielle E. Yohe
Publikováno v:
Clinical Cancer Research. 29:472-487
Purpose: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical
Autor:
Peter M K de Blank, Andrea M Gross, Srivandana Akshintala, Jaishri O Blakeley, Gideon Bollag, Ashley Cannon, Eva Dombi, Jason Fangusaro, Bruce D Gelb, Darren Hargrave, AeRang Kim, Laura J Klesse, Mignon Loh, Staci Martin, Christopher Moertel, Roger Packer, Jonathan M Payne, Katherine A Rauen, Jonathan J Rios, Nathan Robison, Elizabeth K Schorry, Kevin Shannon, David A Stevenson, Elliot Stieglitz, Nicole J Ullrich, Karin S Walsh, Brian D Weiss, Pamela L Wolters, Kaleb Yohay, Marielle E Yohe, Brigitte C Widemann, Michael J Fisher
Publikováno v:
Neuro Oncol
Neuro-Oncology, vol 24, iss 11
Neuro-Oncology, vol 24, iss 11
The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1 (NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase kinase inhibitors (MEKi) block downstream targets of RAS. The recent
Autor:
Angelina V. Vaseva, Peter J. Houghton, Kris C. Wood, Myron S. Ignatius, William D. Figg, Cody J. Peer, Sara M. Zimmerman, Anna T. Rogojina, Yidong Chen, Kunal Baxi, Long Wang, Terry J. Shackleford, Craig M. Goodwin, Marielle E. Yohe, Vanessa Del Pozo, Natalia Garcia
Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector pathway in mediating RAS dependency in a panel of H/NRASQ61X mutant RMS cells and correlates in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8284cff2d8a98fdac0344310698ee
https://doi.org/10.1158/1535-7163.c.6543340
https://doi.org/10.1158/1535-7163.c.6543340
Autor:
Javed Khan, Craig J. Thomas, Keji Zhao, Jack F. Shern, Marc Ferrer, Madhu Lal-Nag, Rajarshi Guha, Thorkell Andresson, Sudipto Das, Frederic G. Barr, Jun S. Wei, Sivasish Sindiri, Xinyu Wen, Abigail Cleveland, Rossella Rota, Silvia Pomella, Alberto Gualtieri, Young Song, Nirmalya Sen, Beat Schaefer, Marco Wachtel, Joana Marques, Xiaohu Zhang, Hsien-Chao Chou, Marielle E. Yohe, Berkley E. Gryder
Supplemental Methods and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3077cb6e000813fbfbc1d1fe147e888d
https://doi.org/10.1158/2159-8290.22532173.v1
https://doi.org/10.1158/2159-8290.22532173.v1