Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mariella Vicinanza"'
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114872- (2024)
Summary: The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy. We identify a distinct nuclear interactome of TFEB, with ubiquitin-specific protease 7 (USP7) emerging as a key post-translational modulator of T
Externí odkaz:
https://doaj.org/article/352bb74afd544312b5ebdcdd93cf6990
Autor:
Sung Min Son, So Jung Park, Eleanna Stamatakou, Mariella Vicinanza, Fiona M. Menzies, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Leucine is a critical amino acid that inhibits autophagy. Here, the authors show that the leucine inhibits autophagy in most cell types, predominantly via its catabolite acetyl CoA, which drives acetylation of raptor, which activates mTORC1, a negati
Externí odkaz:
https://doaj.org/article/629c1efbd3634ae6b0d6ad330b8f9c16
Autor:
Carla F. Bento, David C. Rubinsztein, Mariella Vicinanza, Sung Min Son, Mariana Pavel, Peter Sterk, Cansu Karabiyik, So Jung Park, Farah H. Siddiqi, Rebecca A. Frake
Publikováno v:
Cell Death & Differentiation. 29:1055-1070
Autophagic decline is considered a hallmark of ageing. The activity of this intracytoplasmic degradation pathway decreases with age in many tissues and autophagy induction ameliorates ageing in many organisms, including mice. Autophagy is a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc2c28068c26e59975abcab80b0112e
https://doi.org/10.1038/s41418-021-00903-y
https://doi.org/10.1038/s41418-021-00903-y
Autophagy is an essential catabolic process induced to provide cellular energy sources in response to nutrient limitation through the activation of kinases, like AMP-activated protein kinase (AMPK) and ULK1. Although glucose starvation induces autoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f7d0278f74aab206bef9c2bb05dc10
https://www.repository.cam.ac.uk/handle/1810/323696
https://www.repository.cam.ac.uk/handle/1810/323696
Autor:
So Jung, Park, Rebecca A, Frake, Cansu, Karabiyik, Sung Min, Son, Farah H, Siddiqi, Carla F, Bento, Peter, Sterk, Mariella, Vicinanza, Mariana, Pavel, David C, Rubinsztein
Publikováno v:
Cell death and differentiation. 29(5)
Autophagic decline is considered a hallmark of ageing. The activity of this intracytoplasmic degradation pathway decreases with age in many tissues and autophagy induction ameliorates ageing in many organisms, including mice. Autophagy is a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43ac4b7c25a9b12a4f1b2464bd35d77b
https://pubmed.ncbi.nlm.nih.gov/34848853
https://pubmed.ncbi.nlm.nih.gov/34848853
AMP-activated protein kinase (AMPK) signaling provides a key cellular regulatory system that maintains the balance between energy consumption and production. The heterotrimeric AMPK complex comprising catalytic (α) and regulatory (β and γ) subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb0369d063428f8f6a1aa859d0a9a040
https://doi.org/10.1016/b978-0-12-820538-9.00004-1
https://doi.org/10.1016/b978-0-12-820538-9.00004-1
Publikováno v:
Developmental Cell. 53:619-620
Mitochondrial outer membrane permeabilization (MOMP) is a crucial event enabling apoptotic cell death. In this issue of Developmental Cell, Wang et al. reveal an interaction contributing to full MOMP execution, which depends on endosomes accumulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0e46dad352e3d7c1ada53ba7b73ad9
https://doi.org/10.1016/j.devcel.2020.05.030
https://doi.org/10.1016/j.devcel.2020.05.030
Autor:
Gautam Runwal, Christine Hilcenko, David C. Rubinsztein, Mariella Vicinanza, Fiona M. Menzies, Eleanna Stamatakou, Claudia Puri, Ye Zhu, Marco M. Manni, Marc Bitoun, Kamel Mamchaoui
Publikováno v:
Developmental Cell
Developmental Cell, Elsevier, 2020, 53 (2), pp.154-168. ⟨10.1016/j.devcel.2020.03.018⟩
Developmental Cell, Elsevier, 2020, 53 (2), pp.154-168. ⟨10.1016/j.devcel.2020.03.018⟩
International audience; Autophagy involves engulfment of cytoplasmic contents by double-membraned autophagosomes, which ultimately fuse with lysosomes to enable degradation of their substrates. We recently proposed that the tubular-vesicular recyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54957097085ebbece7eba3070ccd069
https://pubmed.ncbi.nlm.nih.gov/32315611
https://pubmed.ncbi.nlm.nih.gov/32315611
Publikováno v:
Oncotarget
Macroautophagy, hereafter referred to as autophagy, is a process that delivers cytoplasmic material to lysosomes for degradation. When nutrients are scarce, autophagy sustains cellular renovation by recycling cellular constituents (amino acids and fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb350897b16fb60a74c6040d54ea6c02
Autophagosome formation is stimulated by VPS34-dependent PI(3)P formation and by alternative VPS34-independent pathways. We recently described that PI(5)P regulates autophagosome biogenesis and rescues autophagy in VPS34-inactivated cells, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5811aa08f50b329e4859ce37ad0af84f