Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mariela Zeledon"'
Publikováno v:
Neurobiology of Disease, Vol 53, Iss , Pp 26-35 (2013)
Schizophrenia (SZ) is often described as a disease of neuronal connectivity. Cognitive processes such as working memory, which are particularly dependent on the proper functioning of complex cortical circuitry, are disturbed in the disease. Reciproca
Externí odkaz:
https://doaj.org/article/aefb6024bc14427e8b056a09a4eeaedd
Autor:
Pei-Lung Chen, Mikhail V. Pletnikov, Lindsay N. Hayes, Cassandra Obie, Ann E. Pulver, David Valle, A. V. Shevelkin, Gary Steel, Mariela Zeledon, Dimitrios Avramopoulos, Akira Sawa
Publikováno v:
Complex Psychiatry. 2:79-87
Neuregulin 3 (NRG3) is a paralog of NRG1. Genetic studies in schizophrenia demonstrate that risk variants in NRG3 are associated with cognitive and psychotic symptom severity, and several intronic single nucleotide polymorphisms in NRG3 are associate
Autor:
Mariela Zeledon, Megan Szymanksi, Ann E. Pulver, Ruihua Wang, Akira Sawa, Margaret A. Taub, David Valle, Nicole Eckart, Pei-Lung Chen, John A. McGrath, Dimitrios Avramopoulos, Hilary J. Vernon, Gerry Nestadt
Publikováno v:
Complex Psychiatry. 1:36-46
We previously reported a genetic linkage for schizophrenia (SZ; nonparametric linkage score of 4.27) at 10q22 in an Ashkenazi Jewish (AJ) population. In follow-up fine-mapping, we found strong evidence for an association between 3 intronic single nuc
Publikováno v:
Neurobiology of Disease, Vol 53, Iss, Pp 26-35 (2013)
Schizophrenia (SZ) is often described as a disease of neuronal connectivity. Cognitive processes such as working memory, which are particularly dependent on the proper functioning of complex cortical circuitry, are disturbed in the disease. Reciproca
Autor:
Nicholas Katsanis, Miles D. Houslay, Koko Ishizuka, Atsushi Kamiya, Hideyuki Okano, K. Furukori, Mariela Zeledon, Akiko Hayashi-Takagi, Hannah Murdoch, Saurav Seshadri, Hiroaki Kanki, Ken Ichiro Kubo, Beverly Huang, Akira Sawa, Edwin C. Oh, Jon F. Robinson, Kazunori Nakajima, Allan J. Dunlop
Publikováno v:
Nature
Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood. Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorder
Autor:
Yoshimitsu Fukushima, Douglas Blackwood, Akira Sawa, Kumiko Fujii, Yuji Ozeki, Shin Ichi Kano, Benjamin S. Pickard, Daniel Q. Sun, Walter J. Muir, Mariela Zeledon, M. P. Malloy, Kenji Hashimoto, Yukihiko Shirayama, Keiko Wakui, Hiroshi Kunugi
Publikováno v:
Ozeki, Y, Pickard, B S, Kano, S, Malloy, M P, Zeledon, M, Sun, D Q, Fujii, K, Wakui, K, Shirayama, Y, Fukushima, Y, Kunugi, H, Hashimoto, K, Muir, W J, Blackwood, D H & Sawa, A 2011, ' A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: Altered L-serine level associated with disruption of PSAT1 gene expression ', Neuroscience Research, vol. 69, no. 2, pp. 154-160 . https://doi.org/10.1016/j.neures.2010.10.003
L-Serine is required for the synthesis of glycine and D-serine, both of which are NMDA receptor coagonists. Although roles for D-serine and glycine have been suggested in schizophrenia, little is known about the role of the L-serine synthesizing casc