Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Mariela C. Marazita"'
1
Akademický článek
Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of
Autor: Micaela Nievas, Leonardo Romorini, Luciana Isaja, Giulia S. Clas, Soledad Rodríguez-Varela, Sofía Mucci, Tatiana Itzcovich, Bruno de Ambrosi, María E. Scassa, Gustavo E. Sevlever, Ezequiel I. Surace, Mariela C. Marazita
Publikováno v: Stem Cell Research, Vol 69, Iss , Pp 103076- (2023)
Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD disease patient carrying a h
Externí odkaz: https://doaj.org/article/46cf5f4072c949e4a5410ddc489a2966
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2
Akademický článek
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
Autor: Pablo S. Tate, Mariela C. Marazita, Melisa D. Marquioni-Ramella, Angela Maria Suburo
Publikováno v: Journal of Functional Foods, Vol 67, Iss , Pp 103833- (2020)
Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an exce
Externí odkaz: https://doaj.org/article/e5134df2e0c54966a778ef18e1ffff62
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3
Akademický článek
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
Autor: Mariela C. Marazita, Andrea Dugour, Melisa D. Marquioni-Ramella, Juan M. Figueroa, Angela M. Suburo
Publikováno v: Redox Biology, Vol 7, Iss C, Pp 78-87 (2016)
Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk factors. Stress-induced prema
Externí odkaz: https://doaj.org/article/760945e097004f129c11968cf99be547
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4
Akademický článek
Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA.
Autor: María F Ogara, Pablo F Sirkin, Abel L Carcagno, Mariela C Marazita, Silvina V Sonzogni, Julieta M Ceruti, Eduardo T Cánepa
Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61143 (2013)
The maintenance of genomic integrity is of main importance to the survival and health of organisms which are continuously exposed to genotoxic stress. Cells respond to DNA damage by activating survival pathways consisting of cell cycle checkpoints an
Externí odkaz: https://doaj.org/article/75bab212e96443cca3cfe125f24a8502
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5
Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism
Autor: María Soledad Rodríguez-Varela, Leonardo Romorini, Guillermo Agustín Videla-Richardson, Olivia Morris-Hanon, María Elida Scassa, Sofía Mucci, Gustavo Sevlever, Luciana Isaja, Jonathan Vera, Mariela C. Marazita
Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are self-renewing human pluripotent stem cells (hPSCs) that can differentiate to a wide range of specialized cells. Notably, hPSCs enhance their undifferentiated state and self-ren
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf566999e86a48f320b353ad3b65a89
https://pubmed.ncbi.nlm.nih.gov/33244167
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6
Akademický článek
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.
Autor: Mariela C Marazita, M Florencia Ogara, Silvina V Sonzogni, Marcelo Martí, Nelson J Dusetti, Omar P Pignataro, Eduardo T Cánepa
Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35638 (2012)
DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell surv
Externí odkaz: https://doaj.org/article/0e595ffbe060447981e7bb57d4477c2d
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7
Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells
Autor: María Elida Scassa, Damián Darío Fernandez-Espinosa, Guillermo Agustín Videla-Richardson, Mariela C. Marazita, Gustavo Sevlever, Luciana Isaja, Leonardo Romorini, Olivia Morris-Hanon
Publikováno v: Molecular neurobiology. 56(11)
Glioblastoma multiforme is the most aggressive primary brain tumor. Current knowledge suggests that the growth and recurrence of these tumors are due in part to the therapy-resistant glioma stem cell subpopulation, which possesses the ability for sel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5993c731189fbe9feeb7c84ce735c5
https://pubmed.ncbi.nlm.nih.gov/31124078
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8
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
Autor: Juan Manuel Figueroa, Angela M. Suburo, Melisa D. Marquioni-Ramella, Andrea Vanesa Dugour, Mariela C. Marazita
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Redox Biology, Vol 7, Iss C, Pp 78-87 (2016)
Redox Biology
Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk factors. Stress-induced prema
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1877cc697cedc014360bcecde22136
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9
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
Autor: Angela M. Suburo, Mariela C. Marazita, Pablo S. Tate, Melisa D. Marquioni-Ramella
Publikováno v: Journal of Functional Foods, Vol 67, Iss, Pp 103833-(2020)
Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an exce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac5f2008947ca31206e23c099c88a54
https://doi.org/10.1016/j.jff.2020.103833
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10
Glucocorticoid and progesterone mechanisms in photoreceptor survival
Autor: Pablo S. Tate, Marisa A. Cubilla, Melisa D. Marquioni-Ramella, Angela M. Suburo, Vicente Bermudez, Mariela C. Marazita
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Death of retinal photoreceptors is the basis of prevalent blinding diseases. Since steroids might have a therapeutic role in retinal degenerations, we compared the protective effects of dexamethasone and progesterone on photoreceptor death induced by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e566f30b70e15f1ea0b248f980ba9c4
https://doi.org/10.1016/j.exer.2019.107854
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