Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mariel O. Brok"'
Autor:
Eoghan O'Duibhir, Philip Lijnzaad, Joris J Benschop, Tineke L Lenstra, Dik van Leenen, Marian JA Groot Koerkamp, Thanasis Margaritis, Mariel O Brok, Patrick Kemmeren, Frank CP Holstege
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 6, Pp 1-14 (2014)
Abstract Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such experiments may involve indirect effects, these frequently remain uncharacterized.
Externí odkaz:
https://doaj.org/article/632580814a554de6a7ae1d2d159fbd1a
Publikováno v:
Star Protocols
STAR Protocols, Vol 1, Iss 1, Pp 100020-(2020)
STAR Protocols
STAR Protocols, Vol 1, Iss 1, Pp 100020-(2020)
STAR Protocols
Summary Transcription factors are important regulators of cell fate and function. Knowledge about where transcription factors are bound in the genome is crucial for understanding their function. A common method to study protein-DNA interactions is ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064d0cf5cc41bd759a495241ab8b084a
http://europepmc.org/articles/PMC7357673
http://europepmc.org/articles/PMC7357673
Protein-DNA interactions are dynamic and these dynamics are an important aspect of chromatin-associated processes such as transcription or replication. Due to a lack of methods to study on- and off-rates across entire genomes, protein-DNA interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9062fde9c8d564f19de83a88aa46cc
Autor:
Nikol Snoeren, Sander R van Hooff, Rene Adam, Richard van Hillegersberg, Emile E Voest, Catherine Guettier, Paul J van Diest, Maarten W Nijkamp, Mariel O Brok, Dik van Leenen, Marian J A Groot Koerkamp, Frank C P Holstege, Inne H M Borel Rinkes
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49442 (2012)
BACKGROUND AND OBJECTIVES: This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for their colorectal liver metastases (CRLM). METHODS: Tumor gene expr
Externí odkaz:
https://doaj.org/article/1a10b57f5c3045fc984d1e4d6c0e4aff
Chromatin immunoprecipitation (ChIP) is a commonly used technique to investigate which parts of a genome are bound by a particular protein. The result of ChIP is often interpreted in a binary manner: bound or not bound. Due to this focus, ChIP protoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c844e60ea6899b2e664de7f9ce02bf
https://doi.org/10.1101/835926
https://doi.org/10.1101/835926
Autor:
Stephen Buratowski, Dik van Leenen, TaeSoo Kim, Michael S. Kobor, Nathalie Brabers, Sebastiaan van Heesch, Frank C. P. Holstege, Joris J. Benschop, Thomas Hentrich, Cheuk W. Ko, Patrick Kemmeren, Sander R. van Hooff, Katrin Sameith, Julia M. Schulze, Philip Lijnzaad, Mariel O. Brok, Thanasis Margaritis, Marian J. A. Groot Koerkamp, Loes A.L. van de Pasch, Tineke L. Lenstra
Publikováno v:
Molecular Cell. 42:536-549
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7081b516cef54b1cd40c130bb7026cfb
https://doi.org/10.1016/j.molcel.2011.03.026
https://doi.org/10.1016/j.molcel.2011.03.026
Autor:
Wytzke M. van Weerden, Karin G. Hermans, Roel A. de Weger, Marcel G.J. Tilanus, Paul C.M.S. Verhagen, Mariel O. Brok, Tom A. Boon, Jan Trapman
Publikováno v:
International Journal of Cancer, 102, 142-147. Wiley-Liss Inc.
A detailed analysis of chromosome 6 in DNAs from prostate cancers was performed, to define a region for subsequent search for cancer genes. DNA from 4 prostate cancer cell lines and 11 xenografts was used for CGH and whole-chromosome allelotyping wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408ded18c2ee07b76d9b58b430894710
https://doi.org/10.1002/ijc.10677
https://doi.org/10.1002/ijc.10677
Autor:
Maarten W. Nijkamp, Emile E. Voest, Richard van Hillegersberg, Frank C. P. Holstege, Nikol Snoeren, Mariel O. Brok, Sander R. van Hooff, Paul J. van Diest, Inne H.M. Borel Rinkes, René Adam, Marian J. A. Groot Koerkamp, Catherine Guettier, Dik van Leenen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e49442 (2012)
PLoS ONE, Vol 7, Iss 11, p e49442 (2012)
Background and objectives This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for their colorectal liver metastases (CRLM). Methods Tumor gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2798d52ef3ea9ffe16a225c97525f32
http://europepmc.org/articles/PMC3504021
http://europepmc.org/articles/PMC3504021
Autor:
Tineke L. Lenstra, Dik van Leenen, Mariel O. Brok, Patrick Kemmeren, Marian J. A. Groot Koerkamp, Frank C. P. Holstege, Eoghan O'Duibhir, Joris J. Benschop, Philip Lijnzaad, Thanasis Margaritis
Publikováno v:
Molecular Systems Biology
Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such experiments may involve indirect effects, these frequently remain uncharacterized. Here, ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3435a1f387fa29f9aefa67dc1d82a801
http://europepmc.org/articles/PMC4265054
http://europepmc.org/articles/PMC4265054
Autor:
Harm van Bakel, H. T. Marc Timmers, Frank C. P. Holstege, Dik van Leenen, Mariel O. Brok, Marijana Radonjic, Folkert J. van Werven
Publikováno v:
Nucleic Acids Research
Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is a powerful technique to detect in vivo protein–DNA interactions. Due to low yields, ChIP assays of transcription factors generally require amplification of immunoprecipitate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90563aded478701d8581e901408b6f5d
https://doi.org/10.1093/nar/gkm1144
https://doi.org/10.1093/nar/gkm1144