Výsledky vyhledávání - "Mariel Marder"

Akademický článek

Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship

Autor: Sara E. Giraldo, Mauricio Bedoya, Carlos Peña-Varas, Paula A. Santana, Isabel L. Bazzocchi, Ignacio A. Jiménez, Mariel Marder, Nadezdha E. Vergel, Mario F. Guerrero, David Ramírez

Publikováno v: Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 3, Pp 367-380 (2023)

Context: Valeriana pavonii Poepp. & Endl. (Caprifoliaceae), is a plant used in traditional medicine as a tranquilizer in Colombia. Valerian extracts have been widely used since ancient times for their sedative and anxiolytic properties; however, the

Externí odkaz: https://doaj.org/article/72d3d96f0e20497dbddfa6419f0b158e

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Akademický článek

Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy

Autor: Vanina S. Vachetta, Mariel Marder, María F. Troncoso, María T. Elola

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100077- (2022)

Flavonoids are a large group of polyphenols with numerous biological effects on cancer cells. They have been shown to affect proliferation via cell cycle arrest, apoptosis and necrosis and to exert anti-oxidant, anti-inflammatory and anti-mutagenic a

Externí odkaz: https://doaj.org/article/b0c1037cd18d4822953d73219f235a80

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Akademický článek

Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice

Autor: Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder

Publikováno v: Pharmaceuticals, Vol 16, Iss 1, p 129 (2023)

Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a

Externí odkaz: https://doaj.org/article/702c0522a57541afa9b3f4fa4a2bc548

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Akademický článek

Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species

Autor: Carolina Marcucci, Juan Manuel Anselmi Relats, Hernán G. Bach, Fabiola Kamecki, Beatriz G. Varela, Marcelo L. Wagner, Valentina Pastore, Natalia Colettis, Rafael A. Ricco, Mariel Marder

Publikováno v: Heliyon, Vol 6, Iss 12, Pp e05691- (2020)

Folkloric or galenic preparations of valerian roots and rhizomes have been used as sedatives/anxiolytics and sleep inducers since ancient times. “Valerianas” are plants that naturally grow in our region. Although some of them are used in folk med

Externí odkaz: https://doaj.org/article/1cfa2583a74843a4a09884b7459d7eda

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Akademický článek

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

Autor: Josefina Higgs, Cristina Wasowski, Alejandra Marcos, Marko Jukič, Carlos Humberto Paván, Stanislav Gobec, Felicitas de Tezanos Pinto, Natalia Colettis, Mariel Marder

Publikováno v: Heliyon, Vol 5, Iss 3, Pp e01376- (2019)

Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there is a clinical need to develop more effective drugs with fewer adverse reactions.Chalcones are one of

Externí odkaz: https://doaj.org/article/b5c10089ecc749e79bd97fd12b3d553d

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Akademický článek

Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii

Autor: Sara Emilia Giraldo, Javier Rincón, Pilar Puebla, Mariel Marder, Cristina Wasowski, Nadezdha Vergel, Mario Francisco Guerrero

Publikováno v: Biomédica: revista del Instituto Nacional de Salud, Vol 30, Iss 2, Pp 245-50 (2010)

Introducción. El fraccionamiento fitoquímico de Valeriana pavonii, especie vegetal nativa utilizada tradicionalmente en Colombia con fines tranquilizantes, condujo al aislamiento e identificación de la isovaleramida, uno de los principios responsa

Externí odkaz: https://doaj.org/article/01f798164cb443849761daca9f41d85e

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Colony‐stimulating factor‐1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model

Autor: Victoria S. B. Wies Mancini, Anabella A. Di Pietro, Soledad Olmos, Pablo Silva Pinto, Marianela Vence, Mariel Marder, Lionel M. Igaz, María S. Marcora, Juana M. Pasquini, Jorge D. Correale, Laura A. Pasquini

Publikováno v: Journal of Neurochemistry. 160:643-661

Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting from a combination of inflammatory mediators, demyelination, and loss of trophic support. During progressive disease stages, a microenvi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfca4c7232d3a2a850f315a30fb8d9d1
https://doi.org/10.1111/jnc.15566

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Longitudinal Evaluation of a Novel BChE PET Tracer as An Early In Vivo Biomarker in the Brain of a Mouse Model for Alzheimer Disease

Publikováno v: Theranostics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Dipòsit Digital de la UB
Universidad de Barcelona

Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78aa3f6c23115abd785a53a122b059cb
http://hdl.handle.net/10810/51929

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Multitarget 2'-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities

Autor: Carolina Marcucci, Natalia Claudia Colettis, Marina Rademacher, Stanislav Gobec, Fabiola Kamecki, Felicitas de Tezanos Pinto, Diego Carvalho, Alejandra Marcos, Mariel Marder, Josefina Higgs, Simon Žakelj, Juan Andrés Abin-Carriquiry, Damijan Knez

Publikováno v: Neuropharmacology. 201

The complex nature of neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD) and Parkinson's disease (PD) calls for multidirectional treatment. Restoring neurotransmitter levels by combined inhibition of cholinesterases (ChEs) and monoam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5264cc31d5ef3e2e89e0420cede5e6aa
https://pubmed.ncbi.nlm.nih.gov/34653442

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Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species

Autor: Valentina Pastore, Beatriz G. Varela, Fabiola Kamecki, Juan Manuel Anselmi Relats, Marcelo L. Wagner, Natalia Claudia Colettis, Hernán Gerónimo Bach, Rafael A. Ricco, Carolina Marcucci, Mariel Marder

Publikováno v: Heliyon 6 (12) : e05691 (December 2020)
INTA Digital (INTA)
Instituto Nacional de Tecnología Agropecuaria
instacron:INTA
Heliyon
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Heliyon, Vol 6, Iss 12, Pp e05691-(2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3c546c18641aa8b5c63711ed2d1fd
https://www.sciencedirect.com/science/article/pii/S2405844020325342

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