Výsledky vyhledávání - "Marieke W. Veldkamp"

Akademický článek

Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Autor: Sha Chen, Cees A. Schumacher, Shirley C. M. Van Amersfoorth, Jan W. T. Fiolet, Antonius Baartscheer, Marieke W. Veldkamp, Ruben Coronel, Coert J. Zuurbier

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in isolated ventricular cardiomyocytes (CMs). However, other studies with SGLT2i have yielded conflicting results. This may be explained by methodological factors incl

Externí odkaz: https://doaj.org/article/3781e8600e744784a56a10b45357c354

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Akademický článek

Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel

Autor: Marieke W. Veldkamp, Guillaume S. C. Geuzebroek, Antonius Baartscheer, Arie O. Verkerk, Cees A. Schumacher, Gedeon G. Suarez, Wouter R. Berger, Simona Casini, Shirley C. M. van Amersfoorth, Koen T. Scholman, Antoine H. G. Driessen, Charly N. W. Belterman, Antoni C. G. van Ginneken, Joris R. de Groot, Jacques M. T. de Bakker, Carol Ann Remme, Bas J. Boukens, Ruben Coronel

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential

Externí odkaz: https://doaj.org/article/551537e643be4d3280a69b3581a50647

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Akademický článek

Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias

Autor: Christiane Jungen, Katharina Scherschel, Christian Eickholt, Pawel Kuklik, Niklas Klatt, Nadja Bork, Tim Salzbrunn, Fares Alken, Stephan Angendohr, Christiane Klene, Janos Mester, Nikolaj Klöcker, Marieke W. Veldkamp, Udo Schumacher, Stephan Willems, Viacheslav O. Nikolaev, Christian Meyer

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to vent

Externí odkaz: https://doaj.org/article/cb15526be5334b77bb985b10ebd7ca12

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Akademický článek

Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes

Autor: Arie O. Verkerk, Guillaume S.C. Geuzebroek, Marieke W. Veldkamp, Ronald eWilders

Publikováno v: Frontiers in Physiology, Vol 3 (2012)

The autonomic nervous system controls heart rate and contractility through sympathetic and parasympathetic inputs to the cardiac tissue, with acetylcholine (ACh) and noradrenalin (NA) as the chemical transmitters. In recent years, it has become clear

Externí odkaz: https://doaj.org/article/2b9758e1bcec4d31aa0697d3b05e6664

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Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation

Publikováno v: Nature Biomedical Engineering, 6, 389-402
Nature Biomedical Engineering, 6, 389-402. Nature Publishing Group
Nature Biomedical Engineering, 6, 4, pp. 389-402
Nature Biomedical Engineering. NATURE PORTFOLIO
Nature Biomedical Engineering
Nature Biomedical Engineering, 6(4), 389-402. Nature Publishing Group

Functional human atrial myocytes derived from foetal atrial tissue can be massively expanded via a conditional cell-immortalization method, and used in in vitro models of atrial fibrillation.The lack of a scalable and robust source of well-differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d70ba6fcbebb587ffe9e4ecc6d3c032
http://hdl.handle.net/2066/251610

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Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes

Autor: Simona Casini, Vincent Portero, Gerard A Marchal, Carol Ann Remme, Joris R. de Groot, Fransisca A. Nariswari, Kaomei Guan, Antoine H.G. Driessen, Marieke W. Veldkamp, Arie O. Verkerk, Makiri Kawasaki, Nicoline W.E. van den Berg, Isabella Mengarelli

Publikováno v: Cardiovascular Drugs and Therapy
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 33(6), 649-660. Kluwer Academic Publishers

Purpose Several studies have indicated a potential role for SCN10A/NaV1.8 in modulating cardiac electrophysiology and arrhythmia susceptibility. However, by which mechanism SCN10A/NaV1.8 impacts on cardiac electrical function is still a matter of deb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b4ef2ce4fb577a5fa2c0e1f680be0c
https://doi.org/10.1007/s10557-019-06925-6

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Akademický článek

A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome.

Autor: Sven Zumhagen, Marieke W Veldkamp, Birgit Stallmeyer, Antonius Baartscheer, Lars Eckardt, Matthias Paul, Carol Ann Remme, Zahurul A Bhuiyan, Connie R Bezzina, Eric Schulze-Bahr

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67963 (2013)

BACKGROUND:The SCN5A gene encodes for the α-subunit of the cardiac sodium channel NaV1.5, which is responsible for the rapid upstroke of the cardiac action potential. Mutations in this gene may lead to multiple life-threatening disorders of cardiac

Externí odkaz: https://doaj.org/article/d1f560d202674845a7fb9078f90b87b2

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Can we spice up our Christmas dinner?

Autor: N W E Van Den Berg, J. R. de Groot, Marieke W. Veldkamp, E. M. Kemper, F R Piersma, Makiri Kawasaki, Wouter R. Berger, J. Neefs, Sarah W.E. Baalman, E R Meulendijks, Robin Wesselink, Sébastien P.J. Krul

Publikováno v: Netherlands heart journal, 25(12), 664-668. Bohn Stafleu van Loghum

BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-call

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20de5e11ae73a89e21ac153e06255f7
https://doi.org/10.1007/s12471-017-1053-5

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