Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marieke Voets"'
Autor:
Greet Meurs, Vera Hillewaert, Ilse Weuts, Ben Van Hove, Scott Bone, Hector Novoa de Armas, Michiel Van Speybroeck, Geert Verreck, Katrien Backx, Loes Verheyen, Emma Kesselaers, Marieke Voets, Katrien Van Geel, David T. Vodak, Casey Jager, Petros A. Psathas, Jens Ceulemans, Monica Vialpando, Marcus E. Brewster, Sophie Lachau-Durand, Peter Boeykens, Stefanie Smulders, Claire Mackie
Publikováno v:
Journal of Pharmaceutical Sciences
This study investigates 3 amorphous technologies to improve the dissolution rate and oral bioavailability of flubendazole (FLU). The selected approaches are (1) a standard spray-dried dispersion with hydroxypropylmethylcellulose (HPMC) E5 or polyviny
Autor:
Dirk Mariën, Luc De Schaepdrijver, Marieke Voets, Lieve Lammens, Marjolein van Heerden, Cheyma Rhimi
Publikováno v:
Reproductive Toxicology. 56:87-96
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is being explored as excipient for administration of poorly soluble NCE's in pediatrics. In support of pharmaceutical development, non-clinical studies were performed to investigate whether oral and intravenou
Publikováno v:
Archiv der Pharmazie. 337:411-416
The synthesis and biological evaluation of a series of amidinohydrazones (3a-h, 6a-c, 8 and 9) as potential nonsteroidal inhibitors of aldosterone synthase (CYP11B2) are described. The compounds were tested in vitro using CYP11B2-expressing fission y
Publikováno v:
Tetrahedron. 58:531-544
Several different heterocyclic aldehydes, derived from pyrazole, pyrimidine, pyridine, indole and thiazole, were converted to polyheterocyclic compounds containing four to seven rings. The key steps in the sequence were a Knoevenagel condensation of
Autor:
B. D'hooge, S. Smeets, Marieke Voets, Michael A. Abramov, Mikhail L. Petrov, Suzanne Toppet, Wim Dehaen
Publikováno v:
Tetrahedron. 56:3933-3940
2-( ortho -Hydroxyphenyl)-alkynethiolates and -selenolates, obtained through base catalyzed ring cleavage of 4-( ortho -hydroxyphenyl)-1,2,3-thiadiazoles and -1,2,3-selenadiazoles, smoothly transform into 2-benzofuranthiolates and -selenolates. These
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1473-1476
5-Chloro-1,2,3-thiadiazoles 2a,b were treated with organolithium and Grignard reagents giving a novel ring cleavage with the loss of nitrogen and chloride anion, resulting in the formation of alkynyl sulfides 9–14. The results indicate that the mec
Autor:
Loeckie De Zwart, Johan Monbaliu, Tony Greway, Vera Hillewaert, Liesbeth Ceelen, Marieke Voets, Werner Coussement, Greet Teuns
Publikováno v:
The American journal of forensic medicine and pathology. 33(2)
Postmortem redistribution of fentanyl in the rabbit was investigated after application of the 50-μg/h Durogesic pain patch. Patches were applied for 48 hours. Two cycles of patch administration were used before characterization of the postmortem red
Publikováno v:
ChemInform. 29
Publikováno v:
ChemInform. 30
5-Chloro-1,2,3-thiadiazoles 2a,b were treated with organolithium and Grignard reagents giving a novel ring cleavage with the loss of nitrogen and chloride anion, resulting in the formation of alkynyl sulfides 9–14. The results indicate that the mec
Autor:
Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, Iris Antes, Marieke Voets, Christiane Scherer, Catherine Barassin, Ursula Müller-Vieira, Klaus M. Biemel
Publikováno v:
Journal of medicinal chemistry. 48(21)
Recently we proposed inhibition of aldosterone synthase (CYP11B2) as a novel strategy for the treatment of congestive heart failure and myocardial fibrosis. In this study the synthesis and biological evaluation of heteroaryl-substituted naphthalenes