Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marieke Teppner"'
Publikováno v:
Analytical Biochemistry. 498:68-77
Free radical-mediated oxidation of arachidonic acid to prostanoids has been implicated in a variety of pathophysiological conditions such as oxidative stress. Here, we report on the development of a liquid chromatography-mass spectrometry method to m
Publikováno v:
Drug Metabolism and Disposition. 44:560-569
The nonsteroidal androgen-receptor antagonist flutamide is associated with hepatic injury. Oxidative stress and reactive metabolite formation are considered contributing factors to liver toxicity. Here we have used flutamide as a model drug to study
Autor:
Axel Pähler, Guillem Plasencia, Esra Nurten Cece-Esencan, Fabien Fontaine, Marieke Teppner, Andreas Brink, Ismael Zamora
Publikováno v:
SM Analytical and Bioanalytical Techniques. 1:1-12
Autor:
Guillem Plasencia, Fabien Fontaine, Axel Pähler, Marieke Teppner, Esra Nurten Cece-Esencan, Ismael Zamora, Andreas Brink
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:301-310
Rationale Cytochrome P450 (CYP450) reaction phenotyping (CRP) and kinetic studies are essential in early drug discovery to determine which metabolic enzymes react with new drug entities. A new semi-automated computer-assisted workflow for CRP is intr
Autor:
Esra Nurten, Cece-Esencan, Fabien, Fontaine, Guillem, Plasencia, Marieke, Teppner, Andreas, Brink, Axel, Pähler, Ismael, Zamora
Publikováno v:
Rapid communications in mass spectrometry : RCM. 30(2)
Cytochrome P450 (CYP450) reaction phenotyping (CRP) and kinetic studies are essential in early drug discovery to determine which metabolic enzymes react with new drug entities. A new semi-automated computer-assisted workflow for CRP is introduced in
Publikováno v:
Toxicology letters. 238(3)
The early identification of hepatotoxicity is a fundamental goal of preclinical safety studies in drug discovery and early development. Sensitive biomarkers warrant the determination of potential underlying mechanisms that help characterizing a disru