Výsledky vyhledávání - "Marieke Schreurs"

In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors

Autor: Tina Ritschel, Marieke Schreurs, Jan B. Koenderink, Frans G. M. Russel, Rick Greupink, Susanne M. A. Hermans, Jeroen J. M. W. van den Heuvel

Publikováno v: Chemical Research in Toxicology, 27, 5, pp. 873-81
Chemical Research in Toxicology, 27, 873-81

Contains fulltext : 135932.pdf (Publisher’s version ) (Closed access) Drug-induced cholestasis is a frequently observed side effect of drugs and is often caused by an unexpected interaction with the bile salt export pump (BSEP/ABCB11). BSEP is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7311165daa3e3254f8d8ad1fc1788535
https://doi.org/10.1021/tx5000393

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Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions

Autor: Marina S. Benne, Marieke Schreurs, Maarten T. Huisman, Frans G. M. Russel, Rick Greupink

Publikováno v: European Journal of Pharmaceutical Sciences, 49, 5, pp. 819-28
European Journal of Pharmaceutical Sciences, 49, 819-28

Contains fulltext : 136174.pdf (Publisher’s version ) (Closed access) We studied if the clinical pharmacokinetics and drug-drug interactions (DDIs) of the sulfonylurea-derivative glibenclamide can be simulated via a physiologically-based pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac395805ab90431b443f12a6741a4a2
https://hdl.handle.net/2066/136174

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Mutation in subdomain G' of mitochondrial elongation factor G1 is associated with combined OXPHOS deficiency in fibroblasts but not in muscle

Autor: Peter M. van Hasselt, Paul Smits, Woranontee Weraarpachai, Lambert P. van den Heuvel, Hanka Venselaar, Wolfram Haller, Hana Antonicka, Marieke Schreurs, Richard J. Rodenburg, Jan A.M. Smeitink

Publikováno v: European Journal of Human Genetics, 19, 3, pp. 275-9
European Journal of Human Genetics, 19, 275-9

Contains fulltext : 97139.pdf (Publisher’s version ) (Closed access) The mitochondrial translation system is responsible for the synthesis of 13 proteins required for oxidative phosphorylation (OXPHOS), the major energy-generating process of our ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53a10fcb912db6d3c9932f2b9a36b26
https://hdl.handle.net/2066/97139

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Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4

Autor: Rosalinde Masereeuw, Heleen M. Wortelboer, Rick Greupink, Jan B. Koenderink, Jeroen J. M. W. van den Heuvel, Frans G. M. Russel, Marieke Schreurs, Azza A.K. El-Sheikh

Publikováno v: Translational Research, 6, 162, 398-409
Translational Research, 162, 6, pp. 398-409
Translational Research, 162, 398-409

Contains fulltext : 125987.pdf (Publisher’s version ) (Closed access) Renal proximal tubule transporters can play a key role in excretion, pharmacokinetic interactions, and toxicity of immunosuppressant drugs. Basolateral organic anion transporters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32715ca8e0765bf9f407b1108eb42932
http://resolver.tudelft.nl/uuid:966b4e6e-224a-40ed-b7ec-ddce6d8af778

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Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1

Autor: Marieke Schreurs, Jeroen DeGroot, Heleen M. Wortelboer, Maarten T. Huisman, E. van de Steeg, Kitty C.M. Verhoeckx, Roeland Hanemaaijer, D. Ripken, Miriam Verwei, Rick Greupink, Frans G. M. Russel, Irene Nooijen, Maria L. H. Vlaming, Mario Monshouwer

Publikováno v: Drug Metabolism and Disposition, 41, 3, pp. 592-601
Drug Metabolism and Disposition, 41, 592-601

Organic anion-transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has been associated with decreased transport activity. Rosuvastatin is an OATP1B1 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9ee8dc4a24179da170f5186e759210
https://pubmed.ncbi.nlm.nih.gov/23248200

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