Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Marieke Oudelaar A"'
Autor:
Kim L. de Luca, Pim M. J. Rullens, Magdalena A. Karpinska, Sandra S. de Vries, Agnieszka Gacek-Matthews, Lőrinc S. Pongor, Gaëlle Legube, Joanna W. Jachowicz, A. Marieke Oudelaar, Jop Kind
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Accurate repair of DNA damage is critical for maintenance of genomic integrity and cellular viability. Because damage occurs non-uniformly across the genome, single-cell resolution is required for proper interrogation, but sensitive detectio
Externí odkaz:
https://doaj.org/article/4a8adea22a094f2e87579c732274e6d0
Autor:
Abrar Aljahani, Peng Hua, Magdalena A. Karpinska, Kimberly Quililan, James O. J. Davies, A. Marieke Oudelaar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Chromosome conformation capture (3 C) techniques have captured largescale 3D genome architecture. Here the authors present their “Tiled-MCC” approach for generation of 3 C data across megabase-scale loci at very high (up to 20 bp) resolution, whi
Externí odkaz:
https://doaj.org/article/e3638586e78c439f98df7d09869006b5
Autor:
Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar, Damien J. Downes, Alessandro Cavallo, Joe R. Harman, Ron Schwessinger, Akin Bucakci, Lucas Greder, Sara de Ornellas, Danuta Jeziorska, Jelena Telenius, Jim R. Hughes, Marella F. T. R. de Bruijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
RUNX1 is a large and complex gene with two alternative promoters and multiple hematopoietic enhancers. Here the authors show that unlike smaller genes Runx1 becomes sub-compartmentalized during differentiation and gene activation. This subcompartment
Externí odkaz:
https://doaj.org/article/2c70bda05c964692b2499b46b84229b8
Autor:
Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super
Externí odkaz:
https://doaj.org/article/eb63b89aa9ae4973bb86a64000a9ce01
Autor:
Yavor K. Bozhilov, Damien J. Downes, Jelena Telenius, A. Marieke Oudelaar, Emmanuel N. Olivier, Joanne C. Mountford, Jim R. Hughes, Richard J. Gibbons, Douglas R. Higgs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The role of promoters as potential insulator elements has been largely unexplored in mammals. Here the authors show that a single nucleotide variant in the α-globin locus forms a new promoter and acts as an orientation-dependent enhancer-blocking in
Externí odkaz:
https://doaj.org/article/0f0ac4b4b81348c696127f64ad73d2ae
Autor:
Damien J. Downes, Robert A. Beagrie, Matthew E. Gosden, Jelena Telenius, Stephanie J. Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q. Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel Roberts, Arun Shivalingam, Afaf El-Sagheer, A. Marieke Oudelaar, Tom Brown, Veronica J. Buckle, James O. J. Davies, Jim R. Hughes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Current 3C methods generate low-resolution interaction profiles across the genome or high-resolution profiles at a limited number of loci. Here the authors present Nuclear-Titrated Capture-C which produces high-resolution genome-wide interaction prof
Externí odkaz:
https://doaj.org/article/0197837fb40c491eb660e62c1a29c968
Autor:
A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and appl
Externí odkaz:
https://doaj.org/article/a68d72c62d2d48089c3be17071099d2e
Autor:
A. Marieke Oudelaar, Caroline L. Harrold, Lars L. P. Hanssen, Jelena M. Telenius, Douglas R. Higgs, Jim R. Hughes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The coordination of interactions between multiple regulatory elements and genes within a chromatin domain remains poorly understood. Here, the authors use a method to detect multi-way chromatin interactions in a mouse model in which the α-globin dom
Externí odkaz:
https://doaj.org/article/8c56dab7a74b4c60ab85d1cab13fd72b
Autor:
Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in
Externí odkaz:
https://doaj.org/article/e4a9cce559524c16a138443251705752
Autor:
Andrea M. Chiariello, Simona Bianco, A. Marieke Oudelaar, Andrea Esposito, Carlo Annunziatella, Luca Fiorillo, Mattia Conte, Alfonso Corrado, Antonella Prisco, Martin S.C. Larke, Jelena M. Telenius, Renato Sciarretta, Francesco Musella, Veronica J. Buckle, Douglas R. Higgs, Jim R. Hughes, Mario Nicodemi
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2125-2135.e5 (2020)
Summary: We investigate the three-dimensional (3D) conformations of the α-globin locus at the single-allele level in murine embryonic stem cells (ESCs) and erythroid cells, combining polymer physics models and high-resolution Capture-C data. Model p
Externí odkaz:
https://doaj.org/article/0c35df1eab8b4232bbec792059516f82