Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Marieke Op de Beeck"'
Publikováno v:
ChemInform. 42
The furan modified adenosine building block (I) is synthesized and evaluated for interstrand cross-link formation in DNA duplexes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ab1f6d716bcdbf742d143784823c81c
https://doi.org/10.1002/chin.201127196
https://doi.org/10.1002/chin.201127196
Publikováno v:
Chemical Communications, 47, 2796-2798
Chemical Communications, 47, 10, pp. 2796-2798
CHEMICAL COMMUNICATIONS
Chemical Communications, 47, 10, pp. 2796-2798
CHEMICAL COMMUNICATIONS
2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43d684604ab7f49602bd0aff1e6c68b
http://hdl.handle.net/2066/92394
http://hdl.handle.net/2066/92394
Publikováno v:
Collection Symposium Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42dafcab83c2eb572ef415adef05d2cf
https://doi.org/10.1135/css201112282
https://doi.org/10.1135/css201112282
Autor:
Annemieke Madder, Marieke Op de Beeck
Publikováno v:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Chemical reagents that form interstrand cross-links have been used for a long time in cancer therapy. They covalently link two strands of DNA, thereby blocking transcription. Cross-link repair enzymes, however, can restore the transcription processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3e068eddaefa7959be4a0ef6918821
https://pubmed.ncbi.nlm.nih.gov/21162525
https://pubmed.ncbi.nlm.nih.gov/21162525
Publikováno v:
Collection Symposium Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db5fe269483bb684b691054d841e3dc9
https://doi.org/10.1135/css200810210
https://doi.org/10.1135/css200810210