Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marieke Liem-Moolenaar"'
Autor:
Marieke L. de Kam, Joanna Udo de Haes, Joop M. A. van Gerven, Chris Hogg, Adam F. Cohen, Ingrid M C Kamerling, Marieke Liem-Moolenaar, Graham E. Holder, Pierre Peeters, Huub Jan Kleijn, Edwin Spaans, Kari L. Franson
Publikováno v:
British Journal of Clinical Pharmacology. 75:1455-1467
Aims To report the first three studies with SCH 900435, a selective glycine-1 re-uptake inhibitor in development for treating schizophrenia, using systematic evaluations of pharmacodynamics to understand the observed effects. Methods Three double-bli
Autor:
Marieke Liem-Moolenaar, Mandana Rad, Joop M. A. van Gerven, Francesca Lemme, Adam F. Cohen, Stefano Zamuner, Kari L. Franson, Emilio Merlo Pich
Publikováno v:
British Journal of Clinical Pharmacology. 71:907-916
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Several lines of evidence suggest a possible role of 5-HT6 receptor antagonists in dementia or cognitive dysfunction of schizophrenia. SB-742457 is a potent 5-HT6 antagonist and has shown efficacy in diffe
Autor:
Maarten Timmers, J. G. Coen van Hasselt, Joop M. A. van Gerven, Stephan Schmidt, Marieke Liem-Moolenaar, Peter de Boer, Rik C. Schoemaker
Publikováno v:
British Journal of Clinical Pharmacology. 71:886-898
AIM(S) Although scopolamine is a frequently used memory impairment model, the relationships between exposure and corresponding central nervous system (CNS) effects are mostly unknown. The aim of our study was to characterize these using pharmacokinet
Autor:
René S. Kahn, Ron Hijman, Marieke Liem-Moolenaar, Kari L. Franson, Daan J Touw, Joop M. A. van Gerven, Erik T. te Beek, Marieke L. de Kam
Publikováno v:
Journal of Psychopharmacology. 24:1697-1708
In this study, the hypothesis that haloperidol would lead to an amelioration of Δ9-tetrahydrocannabinol (THC)-induced ‘psychotomimetic’ effects was investigated. In a double-blind, placebo-controlled, partial three-way crossover ascending dose s
Autor:
P. De Boer, Remco W. M. Zoethout, Adam F. Cohen, Marieke Liem-Moolenaar, Kari L. Franson, J.M.A. van Gerven, Mark E. Schmidt, ML de Kam
Publikováno v:
Journal of Psychopharmacology. 24:1681-1687
The effects of the selective inhibitor of the glycine transporter 1, R231857, in development for schizophrenia, on the central nervous system (CNS) were investigated in healthy males in the absence and presence of scopolamine. This was a double-blind
Autor:
Adam F. Cohen, CJ Molloy, D Cerneus, Marieke Liem-Moolenaar, KH Brown, J. Burggraaf, D End, ML de Kam, Y van Hensbergen
Publikováno v:
Clinical Pharmacology & Therapeutics. 84:481-487
RWJ-800088 is a novel thrombopoietin mimetic peptide for the treatment of thrombocytopenia. The objectives of this study were to evaluate the pharmacokinetics, pharmacodynamics, and safety of ascending doses of RWJ-800088 administered as a single int
Autor:
Marieke de Kam, Marieke Liem-Moolenaar, Joop M. A. van Gerven, Erica S. Klaassen, Daniël Kleinloog, Ron Hijman, Gabriel E. Jacobs
Publikováno v:
Journal of Psychopharmacology, 26(10), 1307-1316
Δ9-Tetrahydrocannabinol (THC) produces transient psychomimetic effects in healthy volunteers, constituting a pharmacological model for psychosis. The dopaminergic antagonist haloperidol has previously been shown to reduce these effects. This placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c384943bcd396a8d48ce4651331bf64
https://hdl.handle.net/1887/99107
https://hdl.handle.net/1887/99107
Autor:
Daniël, Kleinloog, Marieke, Liem-Moolenaar, Gabriël, Jacobs, Erica, Klaassen, Marieke, de Kam, Ron, Hijman, Joop, van Gerven
Publikováno v:
Journal of psychopharmacology (Oxford, England). 26(10)
Δ⁹-Tetrahydrocannabinol (THC) produces transient psychomimetic effects in healthy volunteers, constituting a pharmacological model for psychosis. The dopaminergic antagonist haloperidol has previously been shown to reduce these effects. This place
Autor:
Marieke, Liem-Moolenaar, Pierre, Peeters, Ingrid M C, Kamerling, Chris, Hogg, Graham, Holder, Huub Jan, Kleijn, Edwin, Spaans, Joanna, Udo De Haes, Marieke L, de Kam, Kari L, Franson, Adam F, Cohen, Joop M A, van Gerven
Publikováno v:
British journal of clinical pharmacology. 75(6)
To report the first three studies with SCH 900435, a selective glycine-1 re-uptake inhibitor in development for treating schizophrenia, using systematic evaluations of pharmacodynamics to understand the observed effects.Three double-blind, placebo-co
Autor:
Marieke, Liem-Moolenaar, Mandana, Rad, Stefano, Zamuner, Adam F, Cohen, Francesca, Lemme, Kari L, Franson, Joop M A, van Gerven, Emilio Merlo, Pich
Publikováno v:
British journal of clinical pharmacology. 71(6)
• Several lines of evidence suggest a possible role of 5-HT(6) receptor antagonists in dementia or cognitive dysfunction of schizophrenia. SB-742457 is a potent 5-HT(6) antagonist and has shown efficacy in different animal models of cognitive impai