Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model

Autor: Salma Assil, Thomas P. Buters, Pieter W. Hameeteman, Charlie Hallard, Nicoline Treijtel, Tessa Niemeyer – Van der Kolk, Marieke L. de Kam, Edwin F. I. I. I. Florencia, Errol P. Prens, Martijn B. A. van Doorn, Robert Rissmann, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin inflammation model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study was t

Externí odkaz: https://doaj.org/article/f03a8555dda44e0c8f9b4a37d47243ce

Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial

Autor: Jannik Rousel, Mahdi Saghari, Lisa Pagan, Andreea Nădăban, Tom Gambrah, Bart Theelen, Marieke L. de Kam, Jorine Haakman, Hein E. C. van der Wall, Gary L. Feiss, Tessa Niemeyer-van der Kolk, Jacobus Burggraaf, Joke A. Bouwstra, Robert Rissmann, Martijn B. A. van Doorn

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 18, p 14315 (2023)

Facial seborrheic dermatitis (SD) is an inflammatory skin disease characterized by erythematous and scaly lesions on the skin with high sebaceous gland activity. The yeast Malassezia is regarded as a key pathogenic driver in this disease, but increas

Externí odkaz: https://doaj.org/article/fefc9342294646a0bbf5de7336f22e9b

Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics

Autor: Aliede E. in ’t Veld, Manon A. A. Jansen, Bertine W. Huisman, Mascha Schoonakker, Marieke L. de Kam, Dirk Jan A. R. Moes, Mariëtte I. E. van Poelgeest, Jacobus Burggraaf, Matthijs Moerland

Publikováno v: Pharmaceutics, Vol 14, Iss 9, p 1958 (2022)

Therapeutic drug monitoring (TDM) of calcineurin inhibitors (i.e., tacrolimus and cyclosporin A) is standard of care after solid organ transplantation. Although the incidence of acute rejection has strongly decreased, there are still many patients wh

Externí odkaz: https://doaj.org/article/7f17bd0e146741d48b5ea7e1ead8b76b

A multimodal, comprehensive characterization of a cutaneous wound model in healthy volunteers

Autor: Wouter ten Voorde, Mahdi Saghari, Jiry Boltjes, Marieke L. de Kam, Ahnjili Zhuparris, Gary Feiss, Thomas P. Buters, Errol P. Prens, Jeffrey Damman, Tessa Niemeyer‐van der Kolk, Matthijs Moerland, Jacobus Burggraaf, Martijn B. A. van Doorn, Robert Rissmann

Publikováno v: Experimental Dermatology. Wiley-Blackwell Publishing Ltd
Experimental Dermatology

Development of pharmacological interventions for wound treatment is challenging due to both poorly understood wound healing mechanisms and heterogeneous patient populations. A standardized and well-characterized wound healing model in healthy volunte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f9c83f8f091954098ce099f154e73
https://pure.eur.nl/en/publications/85f5792e-7116-4dbc-a21f-346ecc6a53c1

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Autor: Wouter ten Voorde, Robert Rissmann, Michelle Osse, Manon A. A. Jansen, G. Feiss, Edwin Florencia, Mascha Schoonakker, Floris C. van Hindevoort, Matthijs Moerland, Erik Lubberts, Pieter W Hameeteman, Thomas P. Buters, Jeffrey Damman, Amit Patel, Iris M. E. Jansen, Marieke L. de Kam, Jacobus Burggraaf, Simon Yona, Derek W. Gilroy, Hendrika W. Grievink

Publikováno v: British Journal of Clinical Pharmacology, 88(2), 680-690. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology, 88(2), 680-690. WILEY

Aims: Whereas intravenous administration of Toll-like receptor 4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb4f5bb07a1c0316ac2a4f7f02dc25a
http://www.scopus.com/inward/record.url?scp=85113808796&partnerID=8YFLogxK