Výsledky vyhledávání - "Marieke E. Klijn"

Time-Dependent Multi-Light-Source Image Classification Combined With Automated Multidimensional Protein Phase Diagram Construction for Protein Phase Behavior Analysis

Autor: Marieke E. Klijn, Jürgen Hubbuch

Publikováno v: Journal of Pharmaceutical Sciences. 109:331-339

Image-based protein phase diagram analysis is key for understanding and exploiting protein phase behavior in the biopharmaceutical field. However, required data analysis has become a notorious time-consuming task since high-throughput screening appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127be68b011033ee244fbb4338ee062a
https://doi.org/10.1016/j.xphs.2019.07.017

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Process analytical technique (PAT) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing

Autor: M.H.M. Eppink, M. Neves Sao Pedro, Marieke E. Klijn, Marcel Ottens

Publikováno v: Journal of Chemical Technology and Biotechnology 97 (2022) 9
Journal of Chemical Technology and Biotechnology, 97(9), 2347-2364

The transition to continuous biomanufacturing is considered the next step to reduce costs and improve process robustness in the biopharmaceutical industry, while also improving productivity and product quality. The platform production process for mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a72c97f8fa43307b4371bd5293106c
https://research.wur.nl/en/publications/process-analytical-technique-pat-miniaturization-for-monoclonal-a

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Correlating multidimensional short-term empirical protein properties to long-term protein physical stability data via empirical phase diagrams

Autor: Jürgen Hubbuch, Marieke E. Klijn

Publikováno v: International Journal of Pharmaceutics. 560:166-174

Identification of long-term stable biopharmaceutical formulations is essential for biopharmaceutical product development. Reduction of the number of long-term storage experiments and a well-defined formulation search space requires knowledge-based fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9992f7395292f22242809363aadc9b
https://doi.org/10.1016/j.ijpharm.2019.02.006

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Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies

Autor: Jürgen Hubbuch, Marieke E. Klijn

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics, 165, 319-336
European Journal of Pharmaceutics and Biopharmaceutics, 165

Imaging is increasingly more utilized as analytical technology in biopharmaceutical formulation research, with applications ranging from subvisible particle characterization to thermal stability screening and residual moisture analysis. This review o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b455ac033fdd1fd0627644e78d77df2c
http://resolver.tudelft.nl/uuid:d7a3d585-a426-42b7-b9c3-2906420bcd30

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Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging

Autor: Anna Katharina Wöll, Marieke E. Klijn, Jürgen Hubbuch

Short-term parameters correlating to long-term protein stability, such as the protein cloud point temperature (Tcloud), are of interest to improve efficiency during protein product development. Such efficiency is reached if short-term parameters are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9154b0c95fb6ce2372e3ebf924c4c780
https://doi.org/10.1021/scimeetings.0c01830

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Influence of image analysis strategy, cooling rate, and sample volume on apparent protein cloud-point temperature determination

Autor: Marieke E. Klijn, Jürgen Hubbuch

Publikováno v: Bioprocess and biosystems engineering, 44 (3), 525-536
Bioprocess and Biosystems Engineering

The protein cloud-point temperature (TCloud) is a known representative of protein–protein interaction strength and provides valuable information during the development and characterization of protein-based products, such as biopharmaceutics. A high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ac8000a00c57de5636405b4c552e2e
https://publikationen.bibliothek.kit.edu/1000127682

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High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening: A case study on HBcAg dimer structures

Autor: Philipp Vormittag, Marieke E. Klijn, Nicolai Bluthardt, Jürgen Hubbuch

Publikováno v: International journal of pharmaceutics. 563

Knowledge-based experimental design can aid biopharmaceutical high-throughput screening (HTS) experiments needed to identify critical manufacturability parameters. Prior knowledge can be obtained via computational methods such as protein property ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d17f348c6efcbdfbe815f5e9a655aaa
https://pubmed.ncbi.nlm.nih.gov/30935914

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Application of Empirical Phase Diagrams for Multidimensional Data Visualization of High-Throughput Microbatch Crystallization Experiments

Autor: Marieke E. Klijn, Jürgen Hubbuch

Publikováno v: Journal of pharmaceutical sciences. 107(8)

Protein phase diagrams are a tool to investigate the cause and consequence of solution conditions on protein phase behavior. The effects are scored according to aggregation morphologies such as crystals or amorphous precipitates. Solution conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f69e2f641b03c99dfef61837c13886c
https://pubmed.ncbi.nlm.nih.gov/29709489

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Redesigning food protein formulations with empirical phase diagrams: A case study on glycerol-poor and glycerol-free formulations

Autor: Jürgen Hubbuch, Marieke E. Klijn

Publikováno v: Food Research International. 125:108609

Redesigning existing food protein formulations is necessary in situations where food authorities propose dose adjustments or removal of currently employed additives. Redesigning formulations involves evaluating substitute additives to obtain similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29c503dac2c49076183efafe27b4400
https://doi.org/10.1016/j.foodres.2019.108609

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