Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Marieke Aarts"'
1
Akademický článek
P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
Autor: Sarah Bowling, Aida Di Gregorio, Margarida Sancho, Sara Pozzi, Marieke Aarts, Massimo Signore, Michael D. Schneider, Juan Pedro Martinez-Barbera, Jesús Gil, Tristan A. Rodríguez
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
During embryo development, cell fitness determines survival but how this is regulated is unclear. Here, the authors show that in early embryonic development and stem cells exiting the naive state, cells sense the fitness of their neighbours and trigg
Externí odkaz: https://doaj.org/article/fa84dfb29e394c458e23e23541902818
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3
Akademický článek
Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
Autor: Sara Costa-Cabral, Rachel Brough, Asha Konde, Marieke Aarts, James Campbell, Eliana Marinari, Jenna Riffell, Alberto Bardelli, Christopher Torrance, Christopher J Lord, Alan Ashworth
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176578 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0149099.].
Externí odkaz: https://doaj.org/article/51dcef158365434191781921fad1b8e1
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5
Akademický článek
CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
Autor: Sara Costa-Cabral, Rachel Brough, Asha Konde, Marieke Aarts, James Campbell, Eliana Marinari, Jenna Riffell, Alberto Bardelli, Christopher Torrance, Christopher J Lord, Alan Ashworth
Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149099 (2016)
Activating KRAS mutations are found in approximately 20% of human cancers but no RAS-directed therapies are currently available. Here we describe a novel, robust, KRAS synthetic lethal interaction with the cyclin dependent kinase, CDK1. This was disc
Externí odkaz: https://doaj.org/article/a24d68f13ee747b2bd872f1e4562042f
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6
Akademický článek
Author Correction: P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
Autor: Sarah Bowling, Aida Di Gregorio, Margarida Sancho, Sara Pozzi, Marieke Aarts, Massimo Signore, Michael D. Schneider, Juan Pedro Martinez-Barbera, Jesús Gil, Tristan A. Rodríguez
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz: https://doaj.org/article/d9d3e8655f944953bb7cd95e65f8e4b7
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7
Supplementary Figures S1-S6 from Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways
Autor: Nicholas C. Turner, Christopher J. Lord, Alan Ashworth, Rachel Brough, Richard Elliott, Maria T. Herrera-Abreu, Ilirjana Bajrami, Marieke Aarts
Figure S1: Hit validation of siRNA screen for determinants of WEE1 inhibitor sensitivity. Figure S2: WEE1 inhibition by MK-1775 induces replication stress without DSBs and is dependent on CDK1/2 activity. Figure S3: Dual inhibition of WEE1 and MYT1 b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9520cc726f771f3e2d49fbbc8bc240
https://doi.org/10.1158/1535-7163.22499680
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