Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Marie-jo Halaby"'
Autor:
Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, Prakash M Hande, Otto Sanchez, Razqallah Hakem
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003259 (2013)
Rnf8 is an E3 ubiquitin ligase that plays a key role in the DNA damage response as well as in the maintenance of telomeres and chromatin remodeling. Rnf8(-/-) mice exhibit developmental defects and increased susceptibility to tumorigenesis. We observ
Externí odkaz:
https://doaj.org/article/1b0a6c96057b4c28bcdaf8f3f483e49a
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna C. Bertol, Madeleine Carew, Sabelo Lukhele, Laura M. Snell, Wenxi Xu, Giselle M. Boukhaled, Heidi Elsaesser, Marie Jo Halaby, Naoto Hirano, Tracy L. McGaha, David G. Brooks
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113047- (2023)
Summary: CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (TTS) cells is unclear. We demonstrate that CD4 TTS cells are quickly primed and begin to divide following tumor initiati
Externí odkaz:
https://doaj.org/article/e4149f45150d4ef1af757d28b5084332
Autor:
Marie Jo Halaby, Tracy L. McGaha
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulation of amino acid availability and metabolism in immune cells is essential for immune system homeostasis and responses to exogenous and endogenous challenges including microbial infection, tumorigenesis and autoimmunity. In myeloid cells the c
Externí odkaz:
https://doaj.org/article/675bd9ec60f046f8bae4ddd60a8d75a0
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna Bertol, Madeleine Carew, Sabelo Lukhele, Laura M Snell, Wenxi Xu, Giselle M Boukhaled, Heidi Elsaesser, Marie jo Halaby, Naoto Hirano, Tracy L McGaha, David G Brooks
Publikováno v:
bioRxiv
CD4 T cells are important effectors of anti-tumor immunity, yet the regulation of CD4 tumor-specific T (TTS) cells during cancer development is still unclear. We demonstrate that CD4 TTScells are initially primed in the tumor draining lymph node and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc68d8039b703b05f19324e33bbb107
https://europepmc.org/articles/PMC10153152/
https://europepmc.org/articles/PMC10153152/
Autor:
Tracy L. McGaha, Marie Jo Halaby
Publikováno v:
Nature Cancer. 2:677-679
Immuno-oncology approaches have shown little efficacy against high-grade glioma, a devastating manifestation of brain cancer. A new study now finds a metabolic vulnerability in IDH1-mutant glioma that can be targeted to reprogram tumor-infiltrating m
Autor:
Marie Jo, Halaby, Tracy L, McGaha
Publikováno v:
Nature cancer. 2(7)
Autor:
Tracy L. McGaha, Marie Jo Halaby
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Regulation of amino acid availability and metabolism in immune cells is essential for immune system homeostasis and responses to exogenous and endogenous challenges including microbial infection, tumorigenesis and autoimmunity. In myeloid cells the c
Autor:
Anne Hakem, Parasvi S. Patel, Jonathan St-Germain, Marie-jo Halaby, Razqallah Hakem, Francesca Mateo, Daniel R. Barnes, Jonathan Beesley, Haithem Barbour, Karim Mekhail, Miquel Angel Pujana, El Bachir Affar, Cheryl H. Arrowsmith, Brian Raught, Samah El Ghamrasni, Arash Algouneh, Kiran Kumar Naidu Guturi, Otto Sanchez, Brandon Ho, Georgia Chenevix-Trench, Shili Duan, Antonis C. Antoniou, Zahra Khan, Karan J. Abraham, Hal K. Berman, Grant W. Brown, Luis Palomero
Publikováno v:
J Clin Invest
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fe09874518ecab3f221c045d16ccb1
https://www.repository.cam.ac.uk/handle/1810/317678
https://www.repository.cam.ac.uk/handle/1810/317678
Autor:
Kebria Hezaveh, Rahul Shinde, Andreas Klotegen, Marie Jo Halaby, Sara Lamorte, Teresa Ciudad, Barbara Gruenwald, Elisabeth G. Foerster, Danica Chaharlangi, Mengdi Guo, Luke Neufeld, Kitty Liu, Priya Makijani, Trevor J. Pugh, Devanand Pinto, Ileana Co, Alison McGuigan, Gun Ho Jang, Rama Kokha, Pamela S. Ohashi, Grainne O'Kane, Steven Gallinger, William W. Navarre, Heather Maughan, Dana J. Philpott, David G. Brooks, Tracy McGaha
Publikováno v:
SSRN Electronic Journal.
Autor:
Kebria Hezaveh, Rahul S. Shinde, Andreas Klötgen, Marie Jo Halaby, Sara Lamorte, M. Teresa Ciudad, Rene Quevedo, Luke Neufeld, Zhe Qi Liu, Robbie Jin, Barbara T. Grünwald, Elisabeth G. Foerster, Danica Chaharlangi, Mengdi Guo, Priya Makhijani, Xin Zhang, Trevor J. Pugh, Devanand M. Pinto, Ileana L. Co, Alison P. McGuigan, Gun Ho Jang, Rama Khokha, Pamela S. Ohashi, Grainne M. O’Kane, Steven Gallinger, William W. Navarre, Heather Maughan, Dana J. Philpott, David G. Brooks, Tracy L. McGaha
Publikováno v:
Immunity
The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated macrophage (TAM) function in pancreatic ductal adenocarcinoma (PDAC). TAM