Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marie-Theres Wittmann"'
Autor:
Matthias Jung, Benjamin M. Häberle, Tristan Tschaikowsky, Marie-Theres Wittmann, Elli-Anna Balta, Vivien-Charlott Stadler, Christiane Zweier, Arnd Dörfler, Christian Johannes Gloeckner, D. Chichung Lie
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants in the TCF4 gene have been identified as susceptibility factors for
Externí odkaz:
https://doaj.org/article/00d94fee11a44d23b830174790c8c8e1
Autor:
Elli-Anna Balta, Marie-Theres Wittmann, Matthias Jung, Elisabeth Sock, Benjamin Martin Haeberle, Birgit Heim, Felix von Zweydorf, Jana Heppt, Julia von Wittgenstein, Christian Johannes Gloeckner, Dieter Chichung Lie
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
SOX11 is a key Transcription Factor (TF) in the regulation of embryonic and adult neurogenesis, whose mutation has recently been linked to an intellectual disability syndrome in humans. SOX11’s transient activity during neurogenesis is critical to
Externí odkaz:
https://doaj.org/article/06b6ae3ed48449bc90521010c660342c
Autor:
Julian Karpf, Petr Unichenko, Nicholas Chalmers, Felix Beyer, Marie-Theres Wittmann, Julia Schneider, Elif Fidan, Andre Reis, Jan Beckervordersandforth, Sebastian Brandner, Stefan Liebner, Sven Falk, Andreas Sagner, Christian Henneberger, Ruth Beckervordersandforth
Publikováno v:
Nature Neuroscience, 25(12), 1626-1638. Nature Publishing Group
Nature neuroscience 25(12), 1626-1638 (2022). doi:10.1038/s41593-022-01192-5
Nature neuroscience 25(12), 1626-1638 (2022). doi:10.1038/s41593-022-01192-5
Neuronal heterogeneity has been established as a pillar of higher central nervous system function, but glial heterogeneity and its implications for neural circuit function are poorly understood. Here we show that the adult mouse dentate gyrus (DG) of
Publikováno v:
Molecular Psychiatry. 28:497-514
The transcription factor FOXG1 serves pleiotropic functions in brain development ranging from the regulation of precursor proliferation to the control of cortical circuit formation. Loss-of-function mutations and duplications of FOXG1 are associated
Autor:
Julia Schneider, Johannes Weigel, Marie‐Theres Wittmann, Pavel Svehla, Sebastian Ehrt, Fang Zheng, Tarek Elmzzahi, Julian Karpf, Lucía Paniagua‐Herranz, Onur Basak, Arif Ekici, Andre Reis, Christian Alzheimer, Felipe Ortega de la O, Sabine Liebscher, Ruth Beckervordersandforth
Publikováno v:
The EMBO journal 41(11), e110409 (2022). doi:10.15252/embj.2021110409
Astrocytes are highly abundant in the mammalian brain, and their functions are of vital importance for all aspects of development, adaption, and aging of the central nervous system (CNS). Mounting evidence indicates the important contributions of ast
Autor:
Fulvia Ferrazzi, Arif B. Ekici, Iris Schäffner, Christian Alzheimer, Marie-Theres Wittmann, D. Chichung Lie, Djoher Nora Abrous, Benjamin M. Häberle, Maria J. Valero-Aracama, André Reis, Muriel Koehl, Elli-Anna Balta, Carlos Henrique Miranda, Fang Zheng, Brian K. Kaspar, Julia von Wittgenstein
Publikováno v:
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2020, 30 (6), pp.3731-3743. ⟨10.1093/cercor/bhz338⟩
Cerebral Cortex, Oxford University Press (OUP), 2020, 30 (6), pp.3731-3743. ⟨10.1093/cercor/bhz338⟩
Neuronal activity initiates transcriptional programs that shape long-term changes in plasticity. Although neuron subtypes differ in their plasticity response, most activity-dependent transcription factors (TFs) are broadly expressed across neuron sub
Autor:
Elisabeth Sock, Michael Wegner, Arif B. Ekici, André Reis, Sayako Katada, Philipp Kirchner, Kinichi Nakashima, Marie Theres Wittmann, Dieter Chichung Lie
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Transcription factor 4 (TCF4) is a crucial regulator of neurodevelopment and has been linked to the pathogenesis of autism, intellectual disability and schizophrenia. As a class I bHLH transcription factor (TF), it is assumed that TCF4 exerts its neu
Autor:
Kathrin Steib, Birgit Heim, Felix von Zweydorf, Elli-Anna Balta, Marius Ueffing, Benjamin M. Häberle, Iris Schäffner, Elisabeth Sock, Julia von Wittgenstein, Elisabeth Kremmer, Dieter Chichung Lie, Marie-Theres Wittmann, Christian Johannes Gloeckner
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific reports 8(1), 16196 (2018). doi:10.1038/s41598-018-34480-x
Scientific Reports
Scientific reports 8(1), 16196 (2018). doi:10.1038/s41598-018-34480-x
The intellectual disability gene, Sox11, encodes for a critical neurodevelopmental transcription factor with functions in precursor survival, neuronal fate determination, migration and morphogenesis. The mechanisms regulating SOX11’s activity remai
Background: Transcription factor 4 (TCF4) has been linked to human neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome (PTHS), autism, and schizophrenia. Recent work demonstrated that TCF4 participates in the control o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5e539082e90c7537d0275b09f626aa
https://doi.org/10.21203/rs.3.rs-44375/v3
https://doi.org/10.21203/rs.3.rs-44375/v3
Publikováno v:
BMC Neuroscience
Background Transcription factor 4 (TCF4) has been linked to human neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome (PTHS), autism, and schizophrenia. Recent work demonstrated that TCF4 participates in the control of