Seminal plasma inhibits Chlamydia trachomatis infection in vitro, and may have consequences on mucosal immunity

Autor: Louis Reot, Cindy Adapen, Claude Cannou, Natalia Nunez, Sabrine Lakoum, Camille Pimienta, Laetitia Lacroix, Olivier Binois, Nelly Frydman, Marie-Thérèse Nugeyre, Roger Le Grand, Elisabeth Menu

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Seminal plasma (SP) is the main vector of C. trachomatis (CT) during heterosexual transmission from male to female. It has immunomodulatory properties and impacts the susceptibility to HIV-1 infection, but its role has not been explored duri

Externí odkaz: https://doaj.org/article/51fd9c8595f84ffe97cf084718c8c1cc

Activation of Toll-Like Receptors Differentially Modulates Inflammation in the Human Reproductive Tract: Preliminary Findings

Autor: Fahd Benjelloun, Héloïse Quillay, Claude Cannou, Romain Marlin, Yoann Madec, Hervé Fernandez, Fabrice Chrétien, Roger Le Grand, Françoise Barré-Sinoussi, Marie-Thérèse Nugeyre, Elisabeth Menu

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The female reproductive tract (FRT) is the main site of entry of sexually transmitted infections (STIs). Toll-like receptors (TLRs) that recognize pathogenic motifs are widely expressed in the FRT. TLR stimulation induces immune activation and local

Externí odkaz: https://doaj.org/article/6859f61e6e5c42469b48390664afe1d4

Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae

Autor: Romain Marlin, Marie-Thérèse Nugeyre, Nicolas Tchitchek, Matteo Parenti, Cécile Lefebvre, Hakim Hocini, Fahd Benjelloun, Claude Cannou, Silvia Nozza, Nathalie Dereuddre-Bosquet, Yves Levy, Françoise Barré-Sinoussi, Gabriella Scarlatti, Roger Le Grand, Elisabeth Menu

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

HIV-1 sexual transmission occurs mainly via mucosal semen exposures. In the female reproductive tract (FRT), seminal plasma (SP) induces physiological modifications, including inflammation. An effective HIV-1 vaccine should elicit mucosal immunity, h

Externí odkaz: https://doaj.org/article/9be9253e678345728e99c5e3f12e2168

Antigen-presenting cells represent targets for R5 HIV-1 infection in the first trimester pregnancy uterine mucosa.

Autor: Romain Marlin, Marie-Thérèse Nugeyre, Claire de Truchis, Nadia Berkane, Amélie Gervaise, Françoise Barré-Sinoussi, Elisabeth Menu

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e5971 (2009)

BACKGROUND: During the first trimester of pregnancy, HIV-1 mother-to-child transmission is relatively rare despite the permissivity of placental cells to cell-to-cell HIV-1 infection. The placenta interacts directly with maternal uterine cells (decid

Externí odkaz: https://doaj.org/article/05c4c7b1be9440aa8cc184a18120adf3

The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication

Autor: Héloïse Quillay, H. El Costa, Marion Duriez, J Ighil, Romain Marlin, Françoise Barré-Sinoussi, Fahd Benjelloun, C. de Truchis, Elisabeth Menu, Claude Cannou, M. Rahmati, Marie-Thérèse Nugeyre

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2016, 9 (3), pp.634-46. ⟨10.1038/mi.2015.87⟩
Mucosal Immunology, 2016, 9 (3), pp.634-46. ⟨10.1038/mi.2015.87⟩

International audience; Macrophages from the decidua basalis (dM), the main uterine mucosa during pregnancy, are weakly permissive to HIV-1 infection. Here, we investigated the mechanisms underlying this natural control. We show, by using freshly pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764efd7d7f7fb011bb2f2f76d831e437
https://hal-pasteur.archives-ouvertes.fr/pasteur-01453433