Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma

Autor: Marie-Thérèse Aloy, Jacqueline Sidi Boumedine, Agathe Deville, David Kryza, Arnaud Gauthier, Delphine Brichart-Vernos, Grégoire Ollier, Veronica La Padula, François Lux, Olivier Tillement, Claire Rodriguez-Lafrasse, Marc Janier

Publikováno v: International Journal of Nanomedicine.

Marie-Thérèse Aloy,1,* Jacqueline Sidi Boumedine,2,* Agathe Deville,2,3 David Kryza,2 Arnaud Gauthier,1,4 Delphine Brichart-Vernos,1,5 Grégoire Ollier,1 Veronica La Padula,5 François Lux,5 Olivier Tillement,5 Claire Rodriguez-Lafr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c4ee80e926dd91d1be2148ffb89db
https://www.dovepress.com/proof-of-concept-of-the-radiosensitizing-effect-of-gadolinium-oxide-na-peer-reviewed-fulltext-article-IJN

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Autor: Camille Verry, Awatef Allouch, Carolyn J. Anderson, Olivier Tillement, Cyrus Chargari, Nathalie Mignet, Benoit Larrat, Marc Janier, Jacqueline Sidi-Boumedine, Kevin M. Prise, Peter Fries, Bich-Thuy Doan, Erika Porcel, Fabien Rossetti, Jacques Balosso, Marie-Caline Abadjian, Dominique Ardail, Frédéric Boschetti, Yannick Crémillieux, Alexandre Detappe, Claire Rodriguez-Lafrasse, Ross Berbeco, Marie-Thérèse Aloy, Sébastien Mériaux, Vu Long Tran, Emmanuel L. Barbier, Sandrine Lacombe, Sandrine Dufort, Matteo Martini, Andreas Müller, Eric Deutsch, Karl T. Butterworth, Emmanuelle Canet-Soulas, Géraldine Le Duc, Franck Denat, Goran Angelovski, Guillaume Bort, Céline Frochot, Jean-Luc Perfettini, Eloise Thomas, Stéphane Roux, Tristan Doussineau, Muriel Barberi-Heyob, Michael J. Evans, François Lux, Charles Truillet, Stephen J. McMahon, Penelope Bouziotis

Publikováno v: The British journal of radiology, vol 92, iss 1093
British Journal of Radiology
British Journal of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩
British Journal of Radiology, British Institute of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩
The British Journal of Radiology
Lux, F, Tran, V L, Thomas, E, Dufort, S, Rossetti, F, Martini, M, Truillet, C, Doussineau, T, Bort, G, Denat, F, Boschetti, F, Angelovski, G, Detappe, A, Crémillieux, Y, Mignet, N, Doan, B-T, Larrat, B, Meriaux, S, Barbier, E, Roux, S, Fries, P, Müller, A, Abadjian, M-C, Anderson, C, Canet-Soulas, E, Bouziotis, P, Barberi-Heyob, M, Frochot, C, Verry, C, Balosso, J, Evans, M, Sidi-Boumedine, J, Janier, M, Butterworth, K, McMahon, S, Prise, K, Aloy, M-T, Ardail, D, Rodriguez-Lafrasse, C, Porcel, E, Lacombe, S, Berbeco, R, Allouch, A, Perfettini, J-L, Chargari, C, Deutsch, E, Le Duc, G & Tillement, O 2019, ' AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine ', British Journal of Radiology, vol. 92, no. 1093, 20180365 . https://doi.org/10.1259/bjr.20180365

International audience; AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the princip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94088f237edf5a1f9b2fb1fad5071931
https://escholarship.org/uc/item/39f7b441

AGuIX radiosensitizing nanoparticles: from molecular events to clinical applications

Autor: Claire Rodriguez-Lafrasse, Marie-Thérèse Aloy, Jacqueline Sidi Boumedine, Shady Kotb, Lucie Sancey, Géraldine Le Duc, François Lux, Jacques Balosso, Camille Verry, Marc Janier, Olivier Tillement

Publikováno v: 63rd annual international meeting of Radiation Reaserach Society
63rd annual international meeting of Radiation Reaserach Society, Oct 2017, Cancun, Mexico
HAL

International audience; AGuIX (Activation and Guidance by Irradiation X) is a non-toxic gadolinium-based nanoparticle (GBN) (due to gadolinium entrapped in DOTA) developed by the Lyon University. It accumulates in the tumor through the enhanced perme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::38a167da2b811eeeb5bdee3454311c4a
https://hal.archives-ouvertes.fr/hal-01610963

In Vitro Radiosensitizing Effects of Ultrasmall Gadolinium Based Particles on Tumour Cells

Autor: C Roulin, Muriel Barberi-Heyob, Emma Armandy, Anna Mignot, Claire Rodriguez-Lafrasse, Pierre Mowat, L Humbert, Pascal Perriat, Wael Rima, Marie-Thérèse Aloy, Marie Dutreix, G. Le Duc, Denise Bechet, Stéphane Roux, François Lux, S Huger, Olivier Tillement

Publikováno v: Journal of Nanoscience and Nanotechnology. 11:7833-7839

Since radiotherapy is widely used in cancer treatment, it is essential to develop strategies which lower the irradiation burden while increasing efficacy and become efficient even in radio resistant tumors. Our new strategy is relying on the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaa1ccae3651a0daf7cbcde3c8ec1290
https://doi.org/10.1166/jnn.2011.4725

Protective Role of Hsp27 Protein Against Gamma Radiation–Induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells

Autor: Elie Hadchity, Marie-Thérèse Aloy, André-Patrick Arrigo, Line Claude, Robert Rousson, Chantal Diaz-Latoud, Claire Rodriguez-Lafrasse, Clara Bionda

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 70:543-553

Purpose The ability of heat shock protein 27 (Hsp27) to protect cells from stressful stimuli and its increased levels in tumors resistant to anticancer therapeutics suggest that it may represent a target for sensitization to radiotherapy. In this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8b8ad9fbc8d81f3270ddb96d8e62eb
https://doi.org/10.1016/j.ijrobp.2007.08.061