Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Marie-Renée Blanchet"'
Autor:
Olivier Courtemanche, Carole-Ann Huppé, Pascale Blais Lecours, Ophélie Lerdu, Joanny Roy, Jean-François Lauzon-Joset, Marie-Renée Blanchet, Mathieu C. Morissette, David Marsolais
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Hypersensitivity pneumonitis (HP) is an interstitial lung disease characterized by antigen-triggered neutrophilic exacerbations. Although CD4+ T cells are sufficient for HP pathogenesis, this never translated into efficient T cell
Externí odkaz:
https://doaj.org/article/fc9640caf71c49fd89d759570b473330
Autor:
Julyanne Brassard, Joanny Roy, Anne-Marie Lemay, Marie-Josée Beaulieu, Emilie Bernatchez, Marc Veillette, Caroline Duchaine, Marie-Renée Blanchet
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Lung dendritic cells (DCs) are divided into two major populations, which include CD103+XCR1+ cDC1s and CD11b+Sirpα+ cDC2s. The maintenance of their relative proportions is dynamic and lung inflammation, such as caused by exposure to lipopolysacchari
Externí odkaz:
https://doaj.org/article/c8db6aa3c47449b987ce8bf568988403
Autor:
Julyanne Brassard, Meredith Elizabeth Gill, Emilie Bernatchez, Véronique Desjardins, Joanny Roy, Philippe Joubert, David Marsolais, Marie-Renée Blanchet
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260636 (2021)
Lung cancer is the leading cause of cancer-related deaths. While the recent use of immune checkpoint inhibitors significantly improves patient outcomes, responsiveness remains restricted to a small proportion of patients. Conventional dendritic cells
Externí odkaz:
https://doaj.org/article/2ca4c9190923498eab9500c256cb2110
Autor:
Anne-Sophie Archambault, Julyanne Brassard, Émilie Bernatchez, Cyril Martin, Vincenzo Di Marzo, Michel Laviolette, Louis-Philippe Boulet, Marie-Renée Blanchet, Nicolas Flamand
Publikováno v:
Cells, Vol 11, Iss 1, p 141 (2022)
High eosinophil (EOS) counts are a key feature of eosinophilic asthma. EOS notably affect asthmatic response by generating several lipid mediators. Mice have been utilized in hopes of defining new pharmacological targets to treat asthma. However, man
Externí odkaz:
https://doaj.org/article/856dc54cb86245238bfddc77045af858
Autor:
Emilie Bernatchez, Anick Langlois, Julyanne Brassard, Nicolas Flamand, David Marsolais, Marie-Renée Blanchet
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179678 (2017)
Pulmonary dendritic cells drive lung responses to foreign antigens, including Saccharopolyspora rectivirgula, a causative agent of hypersensitivity pneumonitis. While the airway inflammatory mechanisms involved in hypersensitivity pneumonitis are wel
Externí odkaz:
https://doaj.org/article/2ba1d6503eff4b3dbb05c7b3346bd5a6
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186639 (2017)
The transcription factor NR4A1 has emerged as a pivotal regulator of the inflammatory response and immune homeostasis. Although contribution of NR4A1 in the innate immune response has been demonstrated, its role in host defense against viral infectio
Externí odkaz:
https://doaj.org/article/392d943bcdff4923a3c84bc6a88096b4
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role of the cannabinoid system in immunity and the inflammatory response in human tissues and animal models. Although the cannabinoid
Externí odkaz:
https://doaj.org/article/ee9097d045f9437696cf90f6a4e7e088
Autor:
Jawairia Atif, Kimberly C. Wiegand, T. Michael Underhill, Jacqueline C.Y. Lai, Pauline Johnson, Spencer A. Freeman, Michael R. Gold, Kelly M. McNagny, Marie-Renée Blanchet, Arif A. Arif, Calvin D. Roskelley, Pamela Dean, Yu-Hsuan Huang
Publikováno v:
Molecular Cancer Research. 19:2096-2109
A rate-limiting step for circulating tumor cells to colonize distant organ sites is their ability to locate a microenvironmental niche that supports their survival and growth. This can be achieved by features intrinsic to the tumor cells and/or by th
Autor:
Geneviève Dion, Caroline Duchaine, Mathieu C. Morissette, Kelly M. McNagny, Carole-Ann Huppé, Emilie Bernatchez, Hugh Rosen, Pascale Blais-Lecours, Marie-Renée Blanchet, David Marsolais, Jean-François Lauzon-Joset
Publikováno v:
Am J Respir Cell Mol Biol
In a proportion of patients with hypersensitivity pneumonitis, the biological and environmental factors that sustain inflammation are ill defined, resulting in no effective treatment option. Bioaerosols found in occupational settings are complex and
Autor:
Anne-Sophie Archambault, Caroline Turcotte, Vincenzo Di Marzo, Marie-Renée Blanchet, Cyril Martin, Michel Laviolette, Élizabeth Dumais, Elyse Y. Bissonnette, Louis-Philippe Boulet, Nicolas Flamand
Publikováno v:
Journal of Leukocyte Biology. 106:1337-1347
2-Arachidonoyl-glycerol (2-AG) is an endocannabinoid with anti-inflammatory properties. Blocking 2-AG hydrolysis to enhance CB2 signaling has proven effective in mouse models of inflammation. However, the expression of 2-AG lipases has never been tho