Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Marie-Pierre Gratacap"'
Autor:
Marine Huillet, Frédéric Lasserre, Marie-Pierre Gratacap, Beatrice Engelmann, Justine Bruse, Arnaud Polizzi, Tiffany Fougeray, Céline Marie Pauline Martin, Clémence Rives, Anne Fougerat, Claire Naylies, Yannick Lippi, Géraldine Garcia, Elodie Rousseau-Bacquie, Cécile Canlet, Laurent Debrauwer, Ulrike Rolle-Kampczyk, Martin von Bergen, Bernard Payrastre, Elisa Boutet-Robinet, Laurence Gamet-Payrastre, Hervé Guillou, Nicolas Loiseau, Sandrine Ellero-Simatos
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100930- (2024)
Background & Aims: The constitutive androstane receptor (CAR) is a nuclear receptor that binds diverse xenobiotics and whose activation leads to the modulation of the expression of target genes involved in xenobiotic detoxification and energy metabol
Externí odkaz:
https://doaj.org/article/17ee943087754a249afd56b554637a6c
Autor:
Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis.
Externí odkaz:
https://doaj.org/article/6ae6386caf484ccca6c2de46387787d6
Autor:
Fanny Vardon-Bounes, Cédric Garcia, Alexandra Piton, Jennifer Series, Marie-Pierre Gratacap, Michaël Poëtte, Thierry Seguin, Laure Crognier, Stéphanie Ruiz, Stein Silva, Jean-Marie Conil, Vincent Minville, Bernard Payrastre
Publikováno v:
Platelets, Vol 33, Iss 6, Pp 918-925 (2022)
During severe sepsis, platelet activation may induce disseminate microvascular thrombosis, which play a key role in critical organ failure. Crucially, most of the studies in this field have explored platelet–leukocyte interactions in animal models,
Externí odkaz:
https://doaj.org/article/e57056cd789d45e38084b6b498b45de6
Autor:
Abdulrahman Mujalli, Julien Viaud, Sonia Severin, Marie-Pierre Gratacap, Gaëtan Chicanne, Karim Hnia, Bernard Payrastre, Anne-Dominique Terrisse
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 583 (2023)
Phosphoinositides (PIs) play a crucial role in regulating intracellular signaling, actin cytoskeleton rearrangements, and membrane trafficking by binding to specific domains of effector proteins. They are primarily found in the membrane leaflets faci
Externí odkaz:
https://doaj.org/article/8bf7234329ed485abc94a2e26f66bf70
Autor:
Sonia Severin, Alessandra Consonni, Gaëtan Chicanne, Sophie Allart, Bernard Payrastre, Marie-Pierre Gratacap
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 958 (2023)
The Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is known to dephosphorylate PtdIns(3,4,5)P3 into PtdIns(3,4)P2 and to interact with several signaling proteins though its docking functions. It has been shown to negatively regulat
Externí odkaz:
https://doaj.org/article/e5a65ef8b94c43c2903ef38c8d6b6203
Autor:
Cédric Garcia, Baptiste Compagnon, Michaël Poëtte, Marie-Pierre Gratacap, François-Xavier Lapébie, Sophie Voisin, Vincent Minville, Bernard Payrastre, Fanny Vardon-Bounes, Agnès Ribes
Publikováno v:
Cells, Vol 11, Iss 9, p 1507 (2022)
Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neopla
Externí odkaz:
https://doaj.org/article/d38a6be72a2947f1bb372031e45555fd
Autor:
Fanny Vardon-Bounes, Marie-Pierre Gratacap, Samuel Groyer, Stéphanie Ruiz, Bernard Georges, Thierry Seguin, Cédric Garcia, Bernard Payrastre, Jean-Marie Conil, Vincent Minville
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223553 (2019)
IntroductionThrombocytopenia is well recognized as a poor prognosis sign associated with increased mortality and prolonged Intensive Care Unit (ICU) stay, particularly in septic patients. Mean platelet volume (MPV) could represent a relevant predicti
Externí odkaz:
https://doaj.org/article/5189db81a1d34204985936bd850c7769
Autor:
Fanny Vardon-Bounes, Stéphanie Ruiz, Marie-Pierre Gratacap, Cédric Garcia, Bernard Payrastre, Vincent Minville
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3494 (2019)
Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous
Externí odkaz:
https://doaj.org/article/9a75aa3379ef4a3fa6424e1bf376a55e
Autor:
Typhaine Anquetil, Marie-Pierre Gratacap, Gaëtan Chicanne, Christoph Kleinschnitz, Eva Geuss, Vincent Larrue, Jean Darcourt, Julien Viaud, Karim Hnia, Aude Jaffre, Denis Vivien, Bernard Payrastre, Cyrille Orset, Romain Solinhac, Bart Vanhaesebroeck
Publikováno v:
EMBO Rep
Endothelium protection is critical, because of the impact of vascular leakage and edema on pathological conditions such as brain ischemia. Whereas deficiency of class II phosphoinositide 3‐kinase alpha (PI3KC2α) results in an increase in vascular
Autor:
Fanny, Vardon Bounes, Vincent, Mémier, Marina, Marcaud, Aemilia, Jacquemin, Hind, Hamzeh-Cognasse, Cédric, Garcia, Jennifer, Series, Pierre, Sié, Vincent, Minville, Marie-Pierre, Gratacap, Bernard, Payrastre
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Sepsis is associated with thrombocytopenia and microvascular thrombosis. Studies have described platelets implication in this pathology but their kinetics of activation and behavior remain poorly known. We show in a mouse model of peritonitis, the ap