Výsledky vyhledávání - "Marie-Pierre de Béthune"

Characterization of Genotypic and Phenotypic Changes in HIV-1-Infected Patients with Virologic Failure on an Etravirine-Containing Regimen in the DUET-1 and DUET-2 Clinical Studies

Autor: Johan Vingerhoets, Bjorn Daems, Lotke Tambuyzer, Steven Nijs, Gaston Picchio, Marie Pierre de Béthune, Hilde Azijn

Publikováno v: AIDS Research and Human Retroviruses. 26:1197-1205

The randomized, placebo-controlled Phase III DUET studies enrolled treatment-experienced, HIV-1-infected patients. We examined the genotypic and phenotypic changes at endpoint relative to baseline, including the emergence of individual reverse transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda74be30f98216d8ebc369f3d689acd
https://doi.org/10.1089/aid.2009.0302

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Short Communication: Activity of Etravirine on Different HIV Type 1 Subtypes:In VitroSusceptibility in Treatment-Naive Patients and Week 48 Pooled DUET Study Data

Autor: Steven Nijs, Johan Vingerhoets, Goedele De Smedt, Sandra De Meyer, Inge Dierynck, Hilde Azijn, Laurence T. Rimsky, Gaston Picchio, Marie-Pierre de Béthune, Lotke Tambuyzer

Publikováno v: AIDS Research and Human Retroviruses. 26:621-624

Etravirine (ETR) has previously shown potent in vitro activity against different primary HIV-1 isolates and demonstrated durable efficacy in treatment-experienced, HIV-1-infected patients in the Phase III DUET studies. The antiviral activity and effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b236c0c03d66dbab097936be381015a
https://doi.org/10.1089/aid.2009.0239

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Resistance profile of etravirine: combined analysis of baseline genotypic and phenotypic data from the randomized, controlled Phase III clinical studies

Autor: Annemie Hoogstoel, Goedele De Smedt, Monika Peeters, Steven Nijs, Johan Vingerhoets, Marie-Pierre de Béthune, Hilde Azijn, Brian Woodfall, Gaston Picchio, Lotke Tambuyzer

Publikováno v: AIDS. 24:503-514

Objective: To refine the genotypic and phenotypic correlates of response to the nonnucleoside reverse transcriptase inhibitor etravirine. Design: Initial analyses identified 13 etravirine resistance-associated mutations (RAMs) and clinical cutoffs (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c34c375322bb8aac750784bd807b9e
https://doi.org/10.1097/qad.0b013e32833677ac

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Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

Autor: Marie-Pierre de Béthune

Publikováno v: Antiviral Research. 85:75-90

It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for the treatment of HIV-1 infection. Although they belong to different and diverse chemical families, they share a common and unique mechanism of action: their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b98b47924cb98044ec8754186a71fbf
https://doi.org/10.1016/j.antiviral.2009.09.008

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Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1H)-one Type Anti-HIV Agents

Autor: Marie-Pierre de Béthune, Said Oumouch, Patrice Palandjian, Jerome Emile Georges Guillemont, Daniel Vernier, Kurt Hertogs, Koen Andries, Chi Hung Nguyen, Laurence Queguiner, David S. Grierson, Abdellah Benjahad, Laurence F B Decrane

Publikováno v: Journal of medicinal chemistry

A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones has been synthesized as new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4b3260eeaf39908174f455f48fc404
https://doi.org/10.1021/jm900802y

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Compilation and prevalence of mutations associated with resistance to non-nucleoside reverse transcriptase inhibitors

Autor: Guenter Kraus, Johan Vingerhoets, Lotke Tambuyzer, Pierre Lecocq, Hilde Azijn, Marie-Pierre de Béthune, Laurence T. Rimsky, Gaston Picchio

Publikováno v: Antiviral Therapy. 14:103-109

Background Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important component of antiretroviral therapy for HIV type-1 (HIV-1)-infected patients. Development of NNRTI resistance can lead to treatment failure and is conferred by the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682287473a9a9c224f233c685843416c
https://doi.org/10.1177/135965350901400114

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Efficacy of Once-Daily Darunavir/Ritonavir 800/100 mg in HIV-Infected, Treatment-Experienced Patients With No Baseline Resistance-Associated Mutations to Darunavir

Autor: G. Diego Miralles, Marie-Pierre de Béthune, Tony Vangeneugden, Sabrina Spinosa-Guzman, Sandra De Meyer

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 49:179-182

Objective: The objective of this study was to examine the potential of once-daily dosing with darunavir/ritonavir 800/100 mg in a HIV-infected, treatment-experienced patient population with no baseline darunavir resistance-associated mutations (RAMs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4dc0726a15fc3f591c6a1dd761e015e
https://doi.org/10.1097/qai.0b013e318183a959

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Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent

Autor: Andrew P. Halestrap, Philippe Gallay, Brigitte Rosenwirth, Kamel Besseghir, Marie-Pierre de Béthune, Dirk Jochmans, Roland Wenger, Michael Bobardt, Jean-Maurice Dumont, Luke A. Pallansch, Roger G. Ptak, Erik De Clercq, Urs T. Ruegg, Pietro Scalfaro, Johan Neyts

Publikováno v: Antimicrobial Agents and Chemotherapy

The introduction of highly active antiretroviral therapy has led to significant changes in disease progression and mortality of human immunodeficiency virus (HIV) type 1 (HIV-1) infection and its sequela, AIDS. HIV-1 infection has been turned into a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44bd4c06094ac984761ecb97f0551c0
https://doi.org/10.1128/aac.01324-07

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Resistance Profile of Darunavir: Combined 24-Week Results from the POWER Trials

Autor: Marie-Pierre de Béthune, Sandra De Meyer, Ben van Baelen, Gaston Picchio, Eric Lefebvre, Tony Vangeneugden, Herwig Van Marck, Els De Paepe

Publikováno v: AIDS Research and Human Retroviruses. 24:379-388

The resistance profile of darunavir (TMC114) in treatment-experienced patients was explored using pooled week 24 data from POWER 1, 2, and 3 at the recommended dose of darunavir with low-dose ritonavir (darunavir/r, 600/100 mg bid, N = 458). Baseline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f417fc81dc89a64fc3836b4597ef36d3
https://doi.org/10.1089/aid.2007.0173

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TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

Autor: Koen Andries, Rudi Pauwels, Marie-Pierre de Béthune, Els Fransen, Dirk Jochmans, Liesbet Smeulders, Hilde Azijn, Johan Vingerhoets, Inky De Baere

Publikováno v: Journal of virology

TMC125 is a potent new investigational nonnucleoside reverse transcriptase inhibitor (NNRTI) that is active against human immunodeficiency virus type 1 (HIV-1) with resistance to currently licensed NNRTIs. Sequential passage experiments with both wil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2961968d62ebdb58b1cf59623fbb969
https://doi.org/10.1128/jvi.79.20.12773-12782.2005

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