Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1

Autor: Wassim Fhayli, Quentin Boëté, Nadjib Kihal, Valérie Cenizo, Pascal Sommer, Walter A. Boyle, Marie-Paule Jacob, Gilles Faury

Publikováno v: Biomolecules, Vol 10, Iss 2, p 173 (2020)

Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin. Elastic fibers endow the lar

Externí odkaz: https://doaj.org/article/450cc632d5f342d09a2eea82724dd032

Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein.

Autor: Ingrid Gomez, Chabha Benyahia, Liliane Louedec, Guy Leséche, Marie-Paule Jacob, Dan Longrois, Xavier Norel

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88021 (2014)

Varicose veins are elongated and dilated saphenous veins. Despite the high prevalence of this disease, its pathogenesis remains unclear.In this study, we investigated the control of matrix metalloproteinases (MMPs) expression by prostaglandin (PG)E�

Externí odkaz: https://doaj.org/article/4c22fe3a3e164fb4ae861b6f00bcece9

Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm

Autor: Olivier Milleron, Marie Paule Jacob, Benoît Ho-Tin-Noé, Marjolijn Renard, Nadine Hanna, Guillaume Jondeau, Laurent Gouya, Marie Sylvie Gross, Sebastien Dupont, Sandy Elbitar, Sébastien Gaertner, Marianne Abifadel, Jeremie Jonquet, Ketty Kessler, Bertrand Isidor, Catherine Boileau, Yves Alembik, Kiyotoshi Sekiguchi, Dianna M. Milewicz, Laurent Tosolini, Mathilde Varret, Mélodie Aubart, Yara Abou Khalil, Youmna Ghaleb, Dongchuan Guo, Jean-Baptiste Michel, Maud Langeois, Louise Benarroch, Ko Tsutsui, Vincenzo Dattilo, Pauline Arnaud, Julie De Backer, Carine Le Goff, Lynn Y. Sakai, Petra El Khoury

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics
GENETICS IN MEDICINE

Purpose: Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening disease with often unrecognized inherited forms. We sought to identify novel pathogenic variants associated with autosomal dominant inheritance of TAAD. Methods: We analyze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04cc9ec2bf0fbf625acf60866281fa2
https://doi.org/10.1038/s41436-020-00947-4

Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

Autor: Grégory Franck, Dimitri Arangalage, Marie-Paule Jacob-Lenet, Jean-Baptiste Michel, Christine Choqueux, Giuseppina Caligiuri, Catherine Deschildre, Antonino Nicoletti, Marion Morvan, Fanny Perez, David Messika-Zeitoun, Léa Cattan-Levy, Guillaume Even, Jamila Laschet, Magnus Bäck, Isabelle Codogno

Publikováno v: Journal of the American College of Cardiology
Journal of the American College of Cardiology, Elsevier, 2019, 73, pp.1043-1054. ⟨10.1016/j.jacc.2018.12.042⟩

Background Intraleaflet hematomas are associated with advanced stages of aortic valve calcification and suspected to be involved in disease progression. However, the mechanism by which the entry of blood cells into the valves affects the biology of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd3750be4a68a6667a9bf2d3a2e4b95
https://doi.org/10.1016/j.jacc.2018.12.042

Fucoidan/VEGF-based surface modification of decellularized pulmonary heart valve improves the antithrombotic and re-endothelialization potential of bioprostheses

Autor: Marie-Noëlle Labour, Hanna Hlawaty, Véronique Ollivier, Aldona Mzyk, Nathalie Charnaux, A. Niemiec-Cyganek, Frédéric Chaubet, Marie-Paule Jacob, Nicolas Marinval, K. Bassand, P. Wilczek, Murielle Maire, Oualid Haddad, K. Jesse, A. Samotus, M. Morenc

Publikováno v: Biomaterials. 172:14-29

Decellularized porcine heart valves offer promising potential as biocompatible prostheses. However, this procedure alter matrix fibres and glycans, leading to lower biomechanical resistance and increased their thrombotic potential. Therefore, their d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d176dfe7b79d7df09b84ae4ad38d0dd9
https://doi.org/10.1016/j.biomaterials.2018.01.054