Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marie-Paule Heitz"'
Autor:
Bernd Buettelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler
Publikováno v:
CHIMIA, Vol 58, Iss 9 (2004)
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists tha
Externí odkaz:
https://doaj.org/article/e78b5258c9904237b4bbb3f669504de2
Autor:
Emmanuel Pinard, Gerhard Trube, Vincent Mutel, Rene Wyler, Anne Bourson, Marie-Paule Heitz, Alexander Alanine, Ramanjit Gill, Bernd Buettelmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:829-832
Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7979588a08d9376725550b28bf5910
https://doi.org/10.1016/s0960-894x(03)00007-6
https://doi.org/10.1016/s0960-894x(03)00007-6
Autor:
Ramanjit Gill, Anne Bourson, Rene Wyler, Emmanuel Pinard, Georg Jaeschke, Marie-Paule Heitz, Bernd Buettelmann, Alexander Alanine, Vincent Mutel, Gerhard Trube
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136e8c1480c8fa3abf899d25de66cc2b
https://doi.org/10.1002/chin.200145151
https://doi.org/10.1002/chin.200145151
Autor:
Marie-Paule Heitz, Emmanuel Pinard, Gerhard Trube, Anne Bourson, Ramanjit Gill, Alexander Alanine, Wyler Rene, Vincent Mutel, Bernd Buettelmann
Publikováno v:
CHIMIA, Vol 58, Iss 9 (2004)
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3561c20feed03174bb7ba14b6cec2167
https://chimia.ch/chimia/article/view/3879
https://chimia.ch/chimia/article/view/3879
Autor:
Jean-Luc Moreau, James N.C. Kew, Edilio Borroni, Marie Paule Heitz, Daniela Alberati, Gwenaëlle Le Pen
Publikováno v:
Biological psychiatry. 54(11)
Background Neonatal ventral hippocampal (NVH) lesions in rats induce behavioral abnormalities at adulthood thought to simulate some aspects of the positive, negative, and cognitive deficits classically observed in schizophrenic patients. Such lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9ef2aa2a70f77fbd36739fb86b3d0e
https://pubmed.ncbi.nlm.nih.gov/14643083
https://pubmed.ncbi.nlm.nih.gov/14643083
Autor:
Rene Wyler, Emmanuel Pinard, Alexander Alanine, Vincent Mutel, Bernd Büttelmann, Ramanjit Gill, Marie Paule Heitz, Anne Bourson, Gerhard Trube
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(19)
Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B subtype selective NMDA receptor antagonist. The structure-activity relationships developed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6c97e0c2b84b42e2b401eaa58fb450
https://pubmed.ncbi.nlm.nih.gov/12951084
https://pubmed.ncbi.nlm.nih.gov/12951084
Autor:
Marie-Paule Heitz, Alexander Alanine, Gerhard Trube, Ramanjit Gill, Vincent Mutel, Bernd Buettelmann, Rene Wyler, Anne Bourson, Emmanuel Pinard
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(10)
A series of 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and analogous quinolines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. 2-Hydroxyalkylamino substitution combines high affinity with selectivity (vs alpha1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd563b7a089446aaf6df93059daa0f5
https://pubmed.ncbi.nlm.nih.gov/12729659
https://pubmed.ncbi.nlm.nih.gov/12729659
Autor:
Rene Wyler, Ramanjit Gill, Emmanuel Pinard, Alexander Alanine, Marie-Paule Heitz, Anne Bourson, Gerhard Trube, Vincent Mutel, Bernd Buettelmann
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc6a743307897f3eaa03f3509c5cecaa
https://doi.org/10.1002/chin.200306204
https://doi.org/10.1002/chin.200306204
Autor:
a Ramanjit Gill Vincent Mutel, Rene Wyler, Emmanuel Pinard, Alexander Alanine, Anne Bourson, Marie-Paule Heitz, Bernd Büttelmann, Gerhard Trube
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(18)
Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575a9d69c10c5264b93e327066db4f4c
https://pubmed.ncbi.nlm.nih.gov/12182873
https://pubmed.ncbi.nlm.nih.gov/12182873
Autor:
Ramanjit Gill, Emmanuel Pinard, Marie-Paule Heitz, Vincent Mutel, Alexander Alanine, Rene Wyler, Anne Bourson, Georg Jaeschke, Gerhard Trube, Bernd Büttelmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(16)
Starting from Ro-25-6981 as a lead compound, highly potent and selective NR1/2B subtype selective NMDA receptor antagonists, with low activity at α 1 adrenergic receptors were developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0ffccfb3668899d51f87e38f9c5c6b
https://pubmed.ncbi.nlm.nih.gov/11514163
https://pubmed.ncbi.nlm.nih.gov/11514163