ATR Inhibition Broadly Sensitizes Soft-Tissue Sarcoma Cells to Chemotherapy Independent of Alternative Lengthening Telomere (ALT) Status

Autor: Stéphanie Verbeke, Audrey Laroche-Clary, François Le Loarer, Marie-Paule Algeo, Andrei Malykh, Antoine Italiano, Vanessa Chaire

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.7488. ⟨10.1038/s41598-020-63294-z⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)

Only few drugs have shown activity in patients with advanced soft-tissue and the median overall survival is only 18 months. Alterations of genes involved in the DNA damage repair pathway have been associated with sarcoma risk and prognosis. ATR plays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86f88c382808e69226c24eda6a7bf97
https://www.hal.inserm.fr/inserm-02862541/document

MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas

Autor: Marie Karanian, Antoine Italiano, Audrey Laroche, Marie-Paule Algeo, Vanessa Chaire, Benjamin Fourneaux

Publikováno v: Oncotarget

// Audrey Laroche 1,2 , Vanessa Chaire 1,2 , Marie-Paule Algeo 1 , Marie Karanian 3 , Benjamin Fourneaux 1,2 and Antoine Italiano 2,3 1 Universite de Bordeaux, Bordeaux, France 2 Institut National de la Sante et de la Recherche Medicale, Institut Ber

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9d2753bc9edc2084c6cba06c1e6655
https://doi.org/10.18632/oncotarget.16345

CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications

Autor: S. Cousin, Aurélien Bourdon, Vanessa Chaire, Ariel Savina, Antoine Italiano, Audrey Laroche-Clary, Marie-Paule Algeo, J. Shutzman, Stéphanie Verbeke, Carlo Lucchesi, F. Le Loarer, Christophe Rey, M. Toulmonde, Valérie Velasco

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 29(4)

Background Inhibition of ChK1 appears as a promising strategy for selectively potentiate the efficacy of chemotherapeutic agents in G1 checkpoint-defective tumor cells such as those that lack functional p53 protein. The p53 pathway is commonly dysreg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28abb7bc44fe5012686b96901f3b800
https://pubmed.ncbi.nlm.nih.gov/29528461

QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field

Autor: Wim E. Crusio, Brice Bonheur, Anna Delprato, Lu Lu, Elissa J. Chesler, Jason A. Bubier, Robert W. Williams, Marie-Paule Algeo

Publikováno v: Genes, Brain and Behavior.

The open field is a classic test used to assess exploratory behavior, anxiety and locomotor activity in rodents. Here, we mapped quantitative trait loci (QTLs) underlying behaviors displayed in an open field, using a panel of 53 BXD recombinant inbre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41152b3e192e78776fcf1a0645b9f71f
https://doi.org/10.1111/gbb.12392

Abstract LB-086: ATR inhibition broadly sensitizes TP53-deficient soft-tissue sarcomas to chemotherapy independent of alternative lengthening telomere (ALT) status: Moving forward to personalized medicine

Autor: Andrei Malykh, Audrey Laroche-Clary, Marie Paule Algeo, François Le Loarer, Antoine Italiano, Vanessa Chaire

Publikováno v: Cancer Research. 78:LB-086

Background: Despite optimal local treatment, 40 to 50% of patients with soft-tissue sarcomas (STS) will develop metastatic disease. Only few drugs have shown activity in the advanced setting and the median overall survival is poor (12 to 18 months).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b9de26e700445e211e52aff3703f2f
https://doi.org/10.1158/1538-7445.am2018-lb-086