The nuclear pore complex prevents sister chromatid recombination during replicative senescence

Autor: Paula Aguilera, Jenna Whalen, Christopher Minguet, Dmitri Churikov, Catherine Freudenreich, Marie-Noëlle Simon, Vincent Géli

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recomb

Externí odkaz: https://doaj.org/article/eca7dfb80a4b4e1f84e98a9a6d5ee4e9

Rad59-facilitated acquisition of Y' elements by short telomeres delays the onset of senescence.

Autor: Dmitri Churikov, Ferose Charifi, Marie-Noëlle Simon, Vincent Géli

Publikováno v: PLoS Genetics, Vol 10, Iss 11, p e1004736 (2014)

Telomerase-negative yeasts survive via one of the two Rad52-dependent recombination pathways, which have distinct genetic requirements. Although the telomere pattern of type I and type II survivors is well characterized, the mechanistic details of sh

Externí odkaz: https://doaj.org/article/0e4d92a5779a46b39967194b7a71939f

Telomeric C-circles localize at nuclear pore complexes in Saccharomyces cerevisiae

Autor: Paula Aguilera, Marion Dubarry, Julien Hardy, Michael Lisby, Marie‐Noëlle Simon, Vincent Géli

Publikováno v: Aguilera, P, Dubarry, M, Hardy, J, Lisby, M, Simon, M-N & Géli, V 2022, ' Telomeric C-circles localize at nuclear pore complexes in Saccharomyces cerevisiae ', EMBO Journal, vol. 41, no. 6, e108736 . https://doi.org/10.15252/embj.2021108736
EMBO Journal
EMBO Journal, 2022, ⟨10.15252/embj.2021108736⟩
EMBO J
Digital.CSIC. Repositorio Institucional del CSIC
instname

As in human cells, yeast telomeres can be maintained in cells lacking telomerase activity by recombination-based mechanisms known as ALT (Alternative Lengthening of Telomeres). A hallmark of ALT human cancer cells are extrachromosomal telomeric DNA e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964b239ef9c20c2b242dc733834cd5c2
Wiley Online Library

Nuclear Pore Complexes in DNA Repair and Telomere Maintenance

Autor: Catherine Dargemont, Marie-Noëlle Simon, Alkmini Kalousi, Vincent Géli, Evi Soutoglou

Publikováno v: Nuclear Pore Complexes in Genome Organization, Function and Maintenance ISBN: 9783319716121

Nuclear Pore complexes (NPCs) constitute unique aqueous channels embedded in the nuclear envelope that insure the selective and massive exchange of macromolecules between these cellular compartments. The NPC is one of the largest proteinaceous assemb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f761684c34ab4d51ba9e2c7c6ebd061e
https://doi.org/10.1007/978-3-319-71614-5_9

SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination

Autor: Sonia Silva, Nadine Eckert-Boulet, Michael Lisby, Dmitri Churikov, Marie-Noëlle Simon, Vincent Géli, Ferose Charifi

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 15, pp.1242-1253. ⟨10.1016/j.celrep.2016.04.008⟩
Cell Reports, Vol 15, Iss 6, Pp 1242-1253 (2016)
Cell Reports, 2016, 15, pp.1242-1253. ⟨10.1016/j.celrep.2016.04.008⟩
Churikov, D, Charifi, F, Eckert-Boulet, N V, Pinela da Silva, S C, Simon, M-N, Lisby, M & Géli, V 2016, ' SUMO-dependent relocalization of eroded telomeres to nuclear pore complexes controls telomere recombination ', Cell Reports, vol. 15, no. 6, pp. 1242-1253 . https://doi.org/10.1016/j.celrep.2016.04.008

Summary In budding yeast, inactivation of telomerase and ensuing telomere erosion cause relocalization of telomeres to nuclear pore complexes (NPCs). However, neither the mechanism of such relocalization nor its significance are understood. We report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2961a194d5ffda63704e8fa5e4dd5e9
https://hal.archives-ouvertes.fr/hal-03085005