15th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT)

Autor: Marie-Noëlle PALUDETTO, Argyro Nikolaou, Laura Weisbach, Anna Kathrin Schuster, Marwin FARRUGIA, Janne Tapio Backman, Maria Francesca Filippi Arriaga, Benjamin Skov Kaas-Hansen, Almudena Ramírez-García

Publikováno v: European Journal of Clinical Pharmacology. 78:1-163

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f0dbc8bd7fce5d1564ecb3693996eed
https://doi.org/10.1007/s00228-022-03333-y

VOTRAGE study: Phase I dose-escalation study of pazopanib in unfit older patients

Autor: L. Digue, Marie-Noëlle Paludetto, Félicien Le Louedec, Pascale Olivier, Loic Mourey, Etienne Chatelut, Thibaud Valentin, Laurent Balardy, Thomas Filleron, Bastien Cabarrou, Carlos Gomez-Roca, Alain Ravaud

Publikováno v: Journal of Geriatric Oncology. 12:759-764

Background Pazopanib is a tyrosine kinase inhibitor given at the approved dose of 800 mg orally once daily (OD), but often requiring individual dose adjustment due to toxicity. Limited data is available to guide prescription in older patients especia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c91f896cc974ccba45dc4f703285d2
https://doi.org/10.1016/j.jgo.2021.02.006

Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug–Drug Interactions in Vitro and in Patient Samples

Autor: Vania Bernardes-Génisson, Florent Puisset, Marie-Noëlle Paludetto, Jean-Luc Stigliani, Cécile Arellano, Anne Robert, Etienne Chatelut

Publikováno v: Chemical Research in Toxicology
Chemical Research in Toxicology, American Chemical Society, 2020, 33 (1), pp.181-190. ⟨10.1021/acs.chemrestox.9b00205⟩
Chemical Research in Toxicology, 2020, 33 (1), pp.181-190. ⟨10.1021/acs.chemrestox.9b00205⟩

International audience; Tyrosine kinase inhibitors (TKI) are targeted anticancer drugs that have been successfully developed over the past 2 decades. To date, many of them (around 70%) require warnings for liver injury and five of them, including paz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbeff118824b605c308619f263fd92a
https://doi.org/10.1021/acs.chemrestox.9b00205

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes - application to establishing CYP2C8 inhibitor selectivity

Autor: Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Terhi Launiainen, Anne M. Filppula, Jani Katajamäki, Helinä Kahma, Aleksi Tornio, Laura Aurinsalo, Jenni Viinamäki, Marie-Noëlle Paludetto

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 162

We developed an in vitro high-throughput cocktail assay with nine major drug-metabolizing CYP enzymes, optimized for screening of time-dependent inhibition. The method was applied to determine the selectivity of the time-dependent CYP2C8 inhibitors g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cae6ebf48a5c802fc4670cefc2ee5b2
https://pubmed.ncbi.nlm.nih.gov/33753217

Formulae recently proposed to estimate renal glomerular filtration rate improve the prediction of carboplatin clearance

Autor: Melanie, White-Koning, Marie Noëlle, Paludetto, Félicien, Le Louedec, Laurence, Gladieff, Christine, Chevreau, Etienne, Chatelut, Florent, Puisset

Publikováno v: Cancer chemotherapy and pharmacology. 85(3)

While doses of carboplatin are mostly individualized according to the Calvert equation based on estimated Glomerular Filtration Rate (eGFR), there is still uncertainty regarding the best formula to predict GFR. Since Janowitz et al. recently proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d87506e5f0b4bb23ad189d077287edbf
https://pubmed.ncbi.nlm.nih.gov/33847805