Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marie-Louise Thorseth"'
Autor:
Marco Carretta, Marie-Louise Thorseth, Aimilia Schina, Dennis Alexander Agardy, Astrid Zedlitz Johansen, Kevin James Baker, Shawez Khan, Anne Mette Askehøj Rømer, Klaire Yixin Fjæstad, Hannes Linder, Dorota Ewa Kuczek, Marco Donia, Lars Grøntved, Daniel Hargbøl Madsen
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Murine syngeneic tumor models have been used extensively for cancer research for several decades and have been instrumental in driving the discovery and development of cancer immunotherapies. These tumor models are very simplistic cancer models, but
Externí odkaz:
https://doaj.org/article/852d9960f5214e53a75dfd50634eb751
Autor:
Marie-Louise Thorseth, Marco Carretta, Christina Jensen, Kasper Mølgaard, Henrik J. Jürgensen, Lars H. Engelholm, Niels Behrendt, Nicholas Willumsen, Daniel H. Madsen
Publikováno v:
Matrix Biology Plus, Vol 13, Iss , Pp 100101- (2022)
Increased remodeling of the extracellular matrix in malignant tumors has been shown to correlate with tumor aggressiveness and a poor prognosis. This remodeling involves degradation of the original extracellular matrix (ECM) and deposition of a new t
Externí odkaz:
https://doaj.org/article/d99c654be5d8417991e7267bd5535abd
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher collagen density and increased stiffness. The structure and collagen dens
Externí odkaz:
https://doaj.org/article/1fe99183b6a442999b44922051191320
Autor:
Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness. The altered ECM of the
Externí odkaz:
https://doaj.org/article/a8b31eed6af14bd29e66f25eb8528c73
Autor:
Astrid Zedlitz Johansen, Marco Carretta, Marie-Louise Thorseth, Shawez Khan, Klaire Yixin Fjæstad, Christian Beltoft Brøchner, Hannes Linder, Christina Ankjærgaard, Marco Donia, Inna Chen, Dorte Lisbet Nielsen, Claus Preibisch Behrens, Daniel Hargbøl Madsen
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1046 (2022)
YKL-40 (also named chitinase 3 like-1 protein [CHI3L1]) is a secreted chitinase-like protein which is upregulated in cancers and suggested to have pro-tumorigenic activity. YKL-40 lacks enzymatic function, but it can bind carbohydrates such as chitin
Externí odkaz:
https://doaj.org/article/78186d8268bd442d8ea8f1b9fe7ac71e
Autor:
Marco Carretta, Anne Mette Rømer, Christina Jensen, Dorota Kuczek, Astrid Johansen, Klaire Fjaestad, Nicholas Willumsen, Mads Andersen, Daniel Hargboel Madsen, Marie-Louise Thorseth
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Klaire Yixin Fjæstad, Anne Mette Askehøj Rømer, Victor Goitea, Astrid Zedlitz Johansen, Marie-Louise Thorseth, Marco Carretta, Lars Henning Engelholm, Lars Grøntved, Niels Junker, Daniel Hargbøl Madsen
Publikováno v:
Fjæstad, K Y, Rømer, A M A, Goitea, V, Johansen, A Z, Thorseth, M L, Carretta, M, Engelholm, L H, Grøntved, L, Junker, N & Madsen, D H 2022, ' Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment ', Oncogene, vol. 41, pp. 1364-1375 . https://doi.org/10.1038/s41388-021-02170-0
Fjæstad, K Y, Rømer, A M A, Goitea, V, Johansen, A Z, Thorseth, M L, Carretta, M, Engelholm, L H, Grøntved, L, Junker, N & Madsen, D H 2022, ' Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment ', Oncogene, vol. 41, no. 9, pp. 1364-1375 . https://doi.org/10.1038/s41388-021-02170-0
Fjæstad, K Y, Rømer, A M A, Goitea, V, Johansen, A Z, Thorseth, M L, Carretta, M, Engelholm, L H, Grøntved, L, Junker, N & Madsen, D H 2022, ' Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment ', Oncogene, vol. 41, no. 9, pp. 1364-1375 . https://doi.org/10.1038/s41388-021-02170-0
The development of immune checkpoint inhibitors (ICI) marks an important breakthrough of cancer therapies in the past years. However, only a limited fraction of patients benefit from such treatments, prompting the search for immune modulating agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132a542c4788a27e2d7a5a87b406a60d
https://curis.ku.dk/ws/files/314704412/s41388_021_02170_0.pdf
https://curis.ku.dk/ws/files/314704412/s41388_021_02170_0.pdf
Autor:
Lars H. Engelholm, Niels Junker, Marco Carretta, Lars Grøntved, Anne Mette Askehøj Rømer, Daniel H. Madsen, Astrid Z. Johansen, Klaire Yixin Fjæstad, Victor Goitea, Marie-Louise Thorseth
The nonselective beta blocker, propranolol, which for decades has been prescribed for treatment of cardiovascular conditions, has recently been used successfully to treat metastatic angiosarcoma. These results have led to an orphan drug designation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06357d46e5854a12391ab50357c979d
https://doi.org/10.1101/2021.03.11.434711
https://doi.org/10.1101/2021.03.11.434711
Autor:
Marco Carretta, Dorota Ewa Kuczek, Majken S. Siersbæk, Daniel H. Madsen, Adrija Kalvisa, Ole Vang, Anne Mette Hvid Larsen, Marie-Louise Thorseth, Astrid Z. Johansen, Lars Grøntved
Publikováno v:
Larsen, A M H, Kuczek, D E, Kalvisa, A, Siersbæk, M S, Thorseth, M L, Johansen, A Z, Carretta, M, Grøntved, L, Vang, O & Madsen, D H 2020, ' Collagen Density Modulates the Immunosuppressive Functions of Macrophages ', Journal of immunology (Baltimore, Md. : 1950), vol. 205, no. 5, pp. 1461-1472 . https://doi.org/10.4049/jimmunol.1900789
Tumor-associated macrophages (TAMs) support tumor growth by suppressing the activity of tumor-infiltrating T cells. Consistently, TAMs are considered a major limitation for the efficacy of cancer immunotherapy. However, the molecular reason behind th
Autor:
Kuczek, Dorota, Larsen, Anne, Marie-Louise Thorseth, Carretta, Marco, Adrija Kalvisa, Siersbæk, Majken, Simões, Ana, Roslind, Anne, Engelholm, Lars, Noessner, Elfriede, Donia, Marco, Svane, Inge, Straten, Per, Grøntved, Lars, Madsen, Daniel
Figure S1. Proliferation of CDLA and CD8A T cells. Figure S2. Fraction of T cell subsets after HD culture or %D culture in different collagen densities. Figure S3. Analysis of CD8+ T cell abundance in areas of high and low collagen density in 20 trip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ce8acb69a19883b353fb1355eca41a