Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Marie-Louise Lehmann"'
1
Ivabradine use in pregnant women—treatment indications and pregnancy outcome: an evaluation of the German Embryotox database
Autor: Katarina Dathe, Evelin Beck, Maria Hoeltzenbein, Christof Schaefer, Marie-Louise Lehmann
Publikováno v: European Journal of Clinical Pharmacology
Purpose Ivabradine has been approved for the treatment of chronic heart failure and chronic stable angina pectoris in Europe. Based on adverse outcomes of reproductive animal studies and the lack of human data, ivabradine is considered contraindicate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e3f33a5ab42aa71558e97bc8e5d47a
https://doi.org/10.1007/s00228-020-03066-w
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2
Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug–drug interactions with different perpetrator drugs
Autor: Walter E. Haefeli, Gerd Mikus, Marlene Schaumaeker, Jürgen Burhenne, Marie-Louise Lehmann, Kathrin I. Foerster
Publikováno v: British Journal of Clinical Pharmacology
Aims Using 3 different perpetrators the impact of voriconazole, cobicistat and rifampicin (single dose), we evaluated the suitability of a microdose cocktail of factor Xa inhibitors (FXaI; rivaroxaban, apixaban and edoxaban; 100 μg in total) to stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8989ec88b2fa526ccf6845ea45f01e
https://doi.org/10.1111/bcp.14277
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3
Perpetrator effects of ciclosporin (P‐glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers
Autor: Antonia Brings, David Czock, Marie-Louise Lehmann, Johanna Weiss, Kathrin I. Foerster, Walter E. Haefeli, Jürgen Burhenne
Publikováno v: Br J Clin Pharmacol
Aims Rivaroxaban exposure is considerably increased by drugs that are combined P-glycoprotein (P-gp) and strong cytochrome P450 (CYP) 3A inhibitors (e.g. ketoconazole). The aim of the present study was to investigate the effects of the potent P-gp in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783ea078204f6e5fc775007b44906a4c
https://doi.org/10.1111/bcp.13934
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4
A short-term inhalation study to assess the reversibility of sensory irritation in human volunteers
Autor: Michael Schäper, Stefan Kleinbeck, Klaus Golka, Marlene Pacharra, Marie Louise Lehmann, Christoph van Thriel, Meinolf Blaszkewicz, Thomas Brüning
Publikováno v: Archives of Toxicology
Archives of toxicology, 94:1687-1701
Sensory irritation is an acute adverse effect caused by chemicals that stimulate chemoreceptors of the upper respiratory tract or the mucous membranes of the outer eye. The avoidance of this end point is of uttermost importance in regulatory toxicolo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1326bf946516e6c88f2ba42e27cbb1
https://pubmed.ncbi.nlm.nih.gov/32185413
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6
Micro-brushing-based technique to gain fresh urothelial cells for gene expression analysis
Autor: Alexander Kress, Jan G. Hengstler, Klaus Golka, Marie-Louise Lehmann, Michael C. Truss, Meinolf Blaszkewicz, Christoph Kuhn, Matthias Hermes
Publikováno v: Journal of Toxicology and Environmental Health, Part A. 80:411-416
The gold standard of saving fresh tissue in liquid nitrogen has some serious disadvantages in that this process is not available in daily medical routine practices even in many tumor centers. Our approach of a new minimally invasive technique is obta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c38bfeb8334bc9eeb946b63fe9337
https://doi.org/10.1080/10937404.2017.1304723
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7
Interindividual differences in chemosensory perception: Toward a better understanding of perceptual ratings during chemical exposures
Autor: Michael Schäper, Stefan Kleinbeck, Marie-Louise Lehmann, Klaus Golka, Stephanie A. Juran, Meinolf Blaszkewicz, Kathrin Hey, Marlene Pacharra, Christoph van Thriel
Publikováno v: Journal of Toxicology and Environmental Health, Part A. 79:1026-1040
Perceptions that arise from stimulation of olfactory and trigeminal receptors in the nasal cavity guide the evaluation of chemical environment in humans. Strong interindividual differences in these assessments may be attributed to nonsensory factors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbafa2ecb9e2d380cb9a408ad183e17
https://doi.org/10.1080/15287394.2016.1219547
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8
Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs
Autor: Walter E. Haefeli, Marie-Louise Lehmann, Gerd Mikus, Jürgen Burhenne, Marlene Schaumaeker, Kathrin I. Foerster
Publikováno v: Clinical pharmacokinetics. 58(9)
The aim of this study was to prove the suitability of simultaneously administered microdoses of the factor Xa inhibitors (FXaIs) rivaroxaban, apixaban and edoxaban (100 µg in total). To evaluate drug–drug interactions, the impact of ketoconazole,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5aa8b3b0924dd4a24de700f551d878
https://pubmed.ncbi.nlm.nih.gov/30828771
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10
Use of magnetic resonance imaging in pharmacogenomics
Autor: Julia C. Stingl, Roberto Viviani, Marie-Louise Lehmann
Publikováno v: British Journal of Clinical Pharmacology. 77:684-694
Because of the large variation in the response to psychoactive medication, many studies have attempted to uncover genetic factors that determine response. While considerable knowledge exists on the large effects of genetic polymorphisms on pharmacoki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52165a6de25f6e713a2f62e7913fc4e4
https://doi.org/10.1111/bcp.12197
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