Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marie-Laure Rives"'
Autor:
Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Publikováno v:
iScience, Vol 19, Iss , Pp 110-118 (2019)
Summary: Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy aga
Externí odkaz:
https://doaj.org/article/22f8a82eaea94df5bb89f782ed04cc2d
Autor:
Pierre Trifilieff, Marie-Laure Rives, Eneko Urizar, Rebecca A. Piskorowski, Harshad D. Vishwasrao, John Castrillon, Claudia Schmauss, Maria Slättman, Mats Gullberg, Jonathan A. Javitch
Publikováno v:
BioTechniques, Vol 51, Iss 2, Pp 111-118 (2011)
The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been demonstrated in heterologous systems using a variety of biochemical and biophysical assays. While these interactions are the subject of intense research because of th
Externí odkaz:
https://doaj.org/article/ae72400782ba4920bcd825a30c1c6bc0
Autor:
Aaron A. Thompson, Michael B. Harbut, Pei-Pei Kung, Nathan K. Karpowich, Jeffrey D. Branson, Joanna C. Grant, Deborah Hagan, Heather A. Pascual, Guoyun Bai, Reza Beheshti Zavareh, Heather R. Coate, Bernard C. Collins, Marjorie Côte, Christine F. Gelin, Kelly L. Damm-Ganamet, Hadi Gholami, Adam R. Huff, Luis Limon, Kevin J. Lumb, Puiying A. Mak, Kohki M. Nakafuku, Edmund V. Price, Amy Y. Shih, Mandana Tootoonchi, Nadeem A. Vellore, Jocelyn Wang, Na Wei, Jeannie Ziff, Scott B. Berger, James P. Edwards, Agnès Gardet, Siquan Sun, Jennifer E. Towne, Jennifer D. Venable, Zhicai Shi, Hariharan Venkatesan, Marie-Laure Rives, Sujata Sharma, Brock T. Shireman, Samantha J. Allen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
NKG2D (natural-killer group 2, member D) is a homodimeric transmembrane receptor that plays an important role in NK, γδ + , and CD8 + T cell-mediated immune responses to environmental stressors such as viral or bacterial infections and oxidative st
Autor:
Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs, Marie-Laure Rives
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Autor:
Kelly L. Damm-Ganamet, Alan D. Wickenden, Taraneh Mirzadegan, Marie-Laure Rives, Heather M. McAllister
Publikováno v:
J Biol Chem
Excitatory amino acid transporters (EAATs) represent a protein family that is an emerging drug target with great therapeutic potential for managing central nervous system disorders characterized by dysregulation of glutamatergic neurotransmission. As
Autor:
Andreas Ebneth, Luke A. Miles, S.J. Hermans, Marie-Laure Rives, Daniel Oehlrich, Berthold Wroblowski, Jasmina Markulić, Michael W. Parker, Ines Royaux, Nancy C. Hancock, Gabriela A. N. Crespi, Andrés A. Trabanco, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero
Publikováno v:
iScience, Vol 19, Iss, Pp 110-118 (2019)
iScience
iScience
Summary Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy agai
Autor:
Raymond J. Patch, Rui Zhang, Suzanne Edavettal, Mark J. Macielag, Annette J. Eckardt, Jiali Li, Marie-Laure Rives, Wilson Edwards, Simon A. Hinke, Xi Qiu, Wenying Jian, Ondrej Libiger, Songmao Zheng, Jey Jeyaseelan, Yin Liang, Shamina M. Rangwala, James N. Leonard, Pamela Hornby
Publikováno v:
European Journal of Medicinal Chemistry. 236:114330
Pramlintide is an equipotent amylin analogue that reduces food intake and body weight in obese subjects and has been clinically approved as an adjunctive therapy for the treatment of adult diabetic patients. However, due to its extremely short half-l
Autor:
Eric Arnoult, Ivona Bakaj, Jenson Qi, Billy Breton, S. Paul Lee, Alessandro Pocai, Shuyuan Zhao, Marie-Laure Rives, Arturo Mancini, Nadia Swanson, Brian Rady, Mark R. Player
Publikováno v:
Molecular Pharmacology. 93:581-591
GPR40 is a clinically validated molecular target for the treatment of diabetes. Many GPR40 agonists have been identified to date, with the partial agonist fasiglifam (TAK-875) reaching phase III clinical trials before its development was terminated d
Autor:
Marie-Laure, Rives, Brian, Rady, Nadia, Swanson, Shuyuan, Zhao, Jenson, Qi, Eric, Arnoult, Ivona, Bakaj, Arturo, Mancini, Billy, Breton, S Paul, Lee, Mark R, Player, Alessandro, Pocai
Publikováno v:
Molecular pharmacology. 93(6)
GPR40 is a clinically validated molecular target for the treatment of diabetes. Many GPR40 agonists have been identified to date, with the partial agonist fasiglifam (TAK-875) reaching phase III clinical trials before its development was terminated d
Publikováno v:
Biochemical pharmacology. 135
Maintaining the integrity of cellular membranes is critical to protecting metabolic activities and genetic information from the environment. Regulation of transport across membranes of essential chemicals, including water, nutrients, hormones and man