Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marie-Laure Delporte"'
Autor:
Lothar Lindemann, Giuseppe Palermo, Michael Derks, Marie-Laure Delporte, Stefan Sturm, Robert James Weikert, Salah Hadi, Georg Jaeschke, Scott Schobel
Publikováno v:
British Journal of Clinical Pharmacology. 84:445-455
SummaryAIM The objectives of this first-in-human study were to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and to determine the maximum tolerated dose (MTD) of single ascending oral doses of RG7342, a positive alloste
Autor:
Philippe Ferber, Susanne Mohr, Morris J. Brown, Maria Cristina De Vera Mudry, Giuseppe Palermo, Katrijn Bogman, Kurt Amrein, Marie-Laure Delporte, Dietmar Schwab
Publikováno v:
Hypertension. 69:189-196
Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), respon
Autor:
Sylvain Celanire, Thierry Demaude, Laurent Provins, Yves Lamberty, Marie-Laure Delporte, Nathalie Van houtvin, Geneviève Lorent, Véronique Durieu, Sabine Defays, Frédéric Denonne, Michel Gillard, Bernard Christophe, Anne Valade, Alain Vanbellinghen, Delphine Hubert, Christel Delaunoy
Publikováno v:
ChemMedChem. 7:2087-2092
The simpler, the better: H(3) histamine receptor (H(3)R) are of interest as therapeutic targets in cognitive and somnolence disorders. Here, lead optimization of H(3)R inverse agonists bearing a thiazolo[5,4-c]piperidine group gave rise to a clinical
Autor:
Laurent Provins, Michel Gillard, Christel Delaunoy, Frédéric Denonne, Sabine Defays, Jean-Marie Nicolas, Geneviève Lorent, Eric Detrait, Véronique Durieu, Bernard Christophe, Yves Lamberty, Alain Vanbellinghen, Nathalie Van houtvin, Sylvain Celanire, Marie-Laure Delporte
Publikováno v:
ChemMedChem. 6:1559-1565
Autor:
Stéphane Meunier, Laurent Provins, Philippe Collart, Ananda Kumar Kanduluru, Christian Wolff, Marie-Laure Delporte, Alain Wagner, Nathalie Pacico, Sébastien Lengelé, Cecile Pegurier, Lakshmana Rao Vadali, Nathalie Bosman, Karine Leclercq
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2542-2545
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R(1) phenyl group improv
Autor:
Yves Lamberty, Valérie Verbois, Frédérique Delannois, Frédéric Denonne, Benedicte Lallemand, Véronique Durieu, Bernard Christophe, Geneviève Lorent, Nathalie Van houtvin, Sylvain Celanire, Christel Delaunoy, Franck Atienzar, Marie-Laure Delporte, Alain Vanbellinghen, Michel Gillard, Laurent Provins
Publikováno v:
ChemMedChem. 5:206-212
Publikováno v:
Hormone and Metabolic Research. 35:337-342
Adipose tissue secretes a large number of physiologically active peptides that often share structural properties with cytokines, and are therefore collectively referred to as "adipocytokines". Some of these are almost exclusively secreted by adipose
Publikováno v:
Clinical Endocrinology. 58:22-29
OBJECTIVE: Adiponectin (ApN) is a fat-derived hormone that enhances insulin sensitivity, controls body weight, prevents atherosclerosis and negatively regulates haematopoiesis and immune functions. In contrast to many proteins secreted by adipose tis
Publikováno v:
Biochemical Journal, Vol. 367, no. Pt 3, p. 677-685 (2002)
The adipose-derived hormone, adiponectin (ApN), has a role in fuel homoeostasis, insulin action and atherosclerosis. Regulation of ApN by catecholamines has scarcely been investigated. We examined the effects of beta-adrenergic agonists (and their se
Autor:
Tohru Funahashi, Sonia Brichard, Marie-Laure Delporte, Roger Detry, Masahiko Takahashi, Yuji Matsuzawa, Christine M Halleux
Publikováno v:
Biochemical and Biophysical Research Communications. 288:1102-1107
Adiponectin (ApN) is thought to play a major role in the pathogenesis of the Metabolic Syndrome. Production of ApN and regulation of its related gene (apM1) have not yet been studied in human visceral adipose tissue. ApN was mainly associated with ad