Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Marie-Laëtitia Thézénas"'
Autor:
Elena I. Ilina, Camille Cialini, Dietlind L. Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P. Niclou, Tanja Müller, Michel Mittelbronn
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103842- (2022)
Summary: Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts revealed a significantly h
Externí odkaz:
https://doaj.org/article/9391a4f387d04c32af06e8d9af82961b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a ro
Externí odkaz:
https://doaj.org/article/bcdccb1f096148578c444773d7337813
Autor:
Haddy K. S. Fye, Paul Mrosso, Lesley Bruce, Marie-Laëtitia Thézénas, Simon Davis, Roman Fischer, Gration L. Rwegasira, Julie Makani, Benedikt M. Kessler
Publikováno v:
Clinical Proteomics, Vol 15, Iss 1, Pp 1-8 (2018)
Abstract Background Red blood cell (RBC) physiology is directly linked to many human disorders associated with low tissue oxygen levels or anemia including chronic obstructive pulmonary disease, congenital heart disease, sleep apnea and sickle cell a
Externí odkaz:
https://doaj.org/article/29cdb70133a94a1480c9a963dd32a43b
Autor:
Thomas P. Chapman, Daniele Corridoni, Seiji Shiraishi, Sumeet Pandey, Anna Aulicino, Simon Wigfield, Maria do Carmo Costa, Marie-Laëtitia Thézénas, Henry Paulson, Roman Fischer, Benedikt M. Kessler, Alison Simmons
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The interplay between NOD2 and TLR2 following recognition of components of the bacterial cell wall peptidoglycan is well-established, however their role in redirecting metabolic pathways in myeloid cells to degrade pathogens and mount antigen present
Externí odkaz:
https://doaj.org/article/ec8c671e88244eb8bddf0895cc76210a
Autor:
Daniele Corridoni, Seiji Shiraishi, Thomas Chapman, Tessa Steevels, Daniele Muraro, Marie-Laëtitia Thézénas, Gennaro Prota, Ji-Li Chen, Uzi Gileadi, Nicola Ternette, Vincenzo Cerundolo, Alison Simmons
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
NOD2 and TLR2 recognize components of bacterial cell wall peptidoglycan and direct defense against enteric pathogens. CD8+ T cells are important for immunity to such pathogens but how NOD2 and TLR2 induce antigen specific CD8+ T cell responses is unk
Externí odkaz:
https://doaj.org/article/9eb738e749514517b1f3c064aa982497
Autor:
G I Welsh, Rutger J. Ploeg, Marie-Laëtitia Thézénas, L K Farmer, Kresse J-C., Lindeman Jhn., Rikke Nørregaard, E Sharples, R H Vaughan, M Kaisar, Benedikt M. Kessler
BackgroundIn brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kidneys that adversely impacts the quality of grafts. Here, we hypothesized that DBD kidneys may undergo proteoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c912f19afc47e8e70b5a7a290a45fc3
https://doi.org/10.1101/2021.06.10.21254305
https://doi.org/10.1101/2021.06.10.21254305
Autor:
Josephine Morris, Aaron Leiblich, Roman Fischer, A Pavey, Rachel Patel, Stuart Wigby, Cláudia C. Mendes, Sekar A, Irem Sepil, Marie-Laëtitia Thézénas, Fan S-J., Benjamin Kroeger, Ben R. Hopkins, Carina Gandy, S M Wainwright, Laura Corrigan, Pauline P. Marie, Hellberg Jeeu., Philip D. Charles, Goberdhan Dci., Clive Wilson, Benedikt M. Kessler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Seminal fluid plays a critical role in reprogramming female physiology and behavior to promote male reproductive success. We show, in the fruit fly, that specific seminal proteins, including the archetypal “female-reprogramming” mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652a8d587ba4263cb8a274fdae293a94
https://ora.ox.ac.uk/objects/uuid:d9179eab-bcc7-43cb-9020-5a7c0c389410
https://ora.ox.ac.uk/objects/uuid:d9179eab-bcc7-43cb-9020-5a7c0c389410
Autor:
Marie-Laëtitia Thézénas, Imre Mäger, Elizabeth Gray, Kevin Talbot, Roman Fischer, Martin R Turner, Alexander G. Thompson, Philip D. Charles, Benedikt M. Kessler, Mathew Wood
Publikováno v:
Clinical Proteomics
Background Extracellular vesicles (EVs) released by neurons and glia reach the cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel perspective on the key intracellular processes associated with the pathogenesis of the n
Autor:
Philip D. Charles, Kevin Talbot, Marie-Laëtitia Thézénas, Roman Fischer, Michele T.M. Hu, Alexander G. Thompson, Benedikt M. Kessler, Samuel Evetts, Martin R Turner, Elizabeth Gray
Publikováno v:
Annals of Neurology. 83:258-268
OBJECTIVE The neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is a heterogeneous clinical syndrome involving multiple molecular pathways. The development of biomarkers for use in therapeutic trials is a priority. We sought to use a hi
TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism
Autor:
Mina Bekheet, Maria I. New, Susan Fotheringham, Reuben Tooze, Nicholas B. La Thangue, Semira Sheikh, Heidi Olzscha, Matthew A. Care, Benedikt M. Kessler, Marie-Laëtitia Thézénas
Publikováno v:
Cancer Research. 76:6975-6987
Histone deacetylase (HDAC) inhibitors have proven useful therapeutic agents for certain hematologic cancers. However, HDAC inhibition causes diverse cellular outcomes, and identification of cancer-relevant pathways within these outcomes remains unres