Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marie-Jose Melief"'
Autor:
Laurens Bogers, Hendrik J. Engelenburg, Malou Janssen, Peter-Paul A. Unger, Marie-José Melief, Annet F. Wierenga-Wolf, Cheng-Chih Hsiao, Matthew R.J. Mason, Jörg Hamann, Jamie van Langelaar, Joost Smolders, Marvin M. van Luijn
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104465- (2023)
Summary: Background: Although distinct brain-homing B cells have been identified in multiple sclerosis (MS), it is unknown how these further evolve to contribute to local pathology. We explored B-cell maturation in the central nervous system (CNS) of
Externí odkaz:
https://doaj.org/article/ab5257161bc347f88c384c428b46a61f
Autor:
Liza Rijvers, Jamie van Langelaar, Laurens Bogers, Marie-José Melief, Steven C. Koetzier, Katelijn M. Blok, Annet F. Wierenga-Wolf, Helga E. de Vries, Jasper Rip, Odilia B.J. Corneth, Rudi W. Hendriks, Roland Grenningloh, Ursula Boschert, Joost Smolders, Marvin M. van Luijn
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Recent clinical trials have shown promising results for the next-generation Bruton’s tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a central role in signaling pathways that govern the development o
Externí odkaz:
https://doaj.org/article/0ecd2fa4ff9540149043120647a04a27
Autor:
Maarten P. Hazenberg, Jeanette Kool, Marie Jose Melief, I. S. Klasen, Anton J. Severijnen, Ina Loeve, Wim B. van den Berg
Publikováno v:
Cellular Immunology. 139:455-467
__Abstract__ T cell lines (B13, B19) were isolated from the lymph nodes of Lewis rats 12 days after an arthritogenic injection of cell wall fragments of Eubacterium aerofaciens (ECW), a major resident of the human intestinal flora. These cell wall fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a6c74cffcd2685549639dc2518b20
https://doi.org/10.1016/0008-8749(92)90085-4
https://doi.org/10.1016/0008-8749(92)90085-4
Autor:
Malou Janssen, Liza Rijvers, Steven C. Koetzier, Annet F. Wierenga-Wolf, Marie-José Melief, Jamie van Langelaar, Tessel F. Runia, Christianne J. M. de Groot, Rinze Neuteboom, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract In MS, pathogenic memory B cells infiltrate the brain and develop into antibody-secreting cells. Chemokine receptors not only define their brain-infiltrating capacity, but also assist in their maturation in germinal centers. How this corresp
Externí odkaz:
https://doaj.org/article/32ebd22e76a44d9db5b13828cd756796
Autor:
Steven C. Koetzier, Jamie van Langelaar, Annet F. Wierenga-Wolf, Marie-José Melief, Kim Pol, Suzanne Musters, Erik Lubberts, Willem A. Dik, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In early multiple sclerosis (MS), an IFN-γhighGM-CSFhighIL-17low CD4+ T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central nervous system. Th17.1 cells express high levels of multidrug resistance protein 1
Externí odkaz:
https://doaj.org/article/28c97a48d5f44f019256739f1b535070
Autor:
Jon Laman, Marvin van Luijn, Karim Kreft, Marlieke Jongsma, Steven Mes, Annet Wierenga-Wolf, Marjan van Meurs, Marie-Jose Melief, Rik van der Kant, Lennert Janssen, Hans Janssen, John Priatel, Rusung Tan, Jacques Neefjes, Rogier Hintzen
Publikováno v:
The Journal of Immunology. 192:53.10-53.10
In GWA studies, CLEC16A has been identified as a risk gene for several major autoimmune diseases, including multiple sclerosis (MS). We show that CLEC16A is increased in MS and functionally links to HLA-II, and uncovered the molecular mechanism of CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::971f47e2a7d8d7fe7e6868c8c29c2cca
https://doi.org/10.4049/jimmunol.192.supp.53.10
https://doi.org/10.4049/jimmunol.192.supp.53.10
Autor:
Steven C. Koetzier, Rinze F. Neuteboom, Annet F. Wierenga-Wolf, Marie-José Melief, C. Louk de Mol, Angelique van Rijswijk, Willem A. Dik, Bieke Broux, Ronald van der Wal, Sjoerd A. A. van den Berg, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Background: Multiple sclerosis (MS) patients are protected from relapses during pregnancy and have an increased relapse risk after delivery. It is unknown how pregnancy controls disease-contributing CD4+ T helper (Th) cells and whether this differs i
Externí odkaz:
https://doaj.org/article/778b2341cf854ec3b228ec869c213250
Autor:
Steven C. Koetzier, Jamie van Langelaar, Marie-José Melief, Annet F. Wierenga-Wolf, Cato E. A. Corsten, Katelijn M. Blok, Cindy Hoeks, Bieke Broux, Beatrijs Wokke, Marvin M. van Luijn, Joost Smolders
Publikováno v:
Cells, Vol 11, Iss 10, p 1634 (2022)
The effector programs of CD8+ memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8+ memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood,
Externí odkaz:
https://doaj.org/article/9621a0d9da044e859945b53b22f5d3a4
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