Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marie-Jose J. Pouwels"'
Autor:
André J. Olthaar, Frank C. Huvers, Ad R. M. M. Hermus, Jos A. Lutterman, Paul N. Span, Marie-Jose J. Pouwels, Cees J. Tack, C.G.J. Sweep
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 89, 10, pp. 5132-7
Journal of Clinical Endocrinology and Metabolism, 89, 5132-7
Journal of Clinical Endocrinology and Metabolism, 89, 5132-7
Contains fulltext : 59311.pdf (Publisher’s version ) (Open Access) It has been proposed that the hexosamine pathway acts as a nutrient-sensing pathway, protecting the cell against abundant fuel supply, and that accumulation of hexosamines represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c47613f1dd2e13f35a75181fec56c
https://doi.org/10.1210/jc.2004-0291
https://doi.org/10.1210/jc.2004-0291
Publikováno v:
Diabetic Medicine, 20, 76-9
Diabetic Medicine, 20, 1, pp. 76-9
Diabetic Medicine, 20, 1, pp. 76-9
Item does not contain fulltext AIMS: Despite high-dose s.c. insulin therapy, some Type 2 diabetes mellitus (DM) patients remain in poor metabolic control. We investigated whether a period of euglycaemia using i.v. insulin, followed by continuous subc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c8afcdf828a0f18b94a7a86be9dc4b
https://doi.org/10.1046/j.1464-5491.2003.00848.x
https://doi.org/10.1046/j.1464-5491.2003.00848.x
Autor:
Marie-Jose J. Pouwels, Cees J. Tack, Paul N. Span, Jos A. Lutterman, Paul Smits, Judith R. Jacobs
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:2099-2103
Overactivity of the hexosamine biosynthetic pathway may underlie hyperglycemia-associated insulin resistance, but to date human studies are lacking. Hexosamine pathway activation can be mimicked by glucosamine (GlcN). In the present placebo-controlle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f567566156ce7684b7b563c37748682
https://doi.org/10.1210/jcem.86.5.7470
https://doi.org/10.1210/jcem.86.5.7470
Autor:
C.G.J. Sweep, Ad R. M. M. Hermus, Remko R. Bosch, Marie-Jose J. Pouwels, Paul N. Span, André J. Olthaar
Publikováno v:
Clinical Chemistry. 47:944-946
It has been suggested that the hexosamine biosynthetic pathway is involved in the pathogenesis of insulin resistance in patients with type 2 diabetes mellitus because the activity of the rate-limiting enzyme of this pathway, glutamine:fructose-6-phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9c01a940648d01658bc34b00eaa59a
https://doi.org/10.1093/clinchem/47.5.944
https://doi.org/10.1093/clinchem/47.5.944
Autor:
Remko R. Bosch, Cees J. Tack, André J. Olthaar, C.G.J. Sweep, Ad R. M. M. Hermus, Marie-Jose J. Pouwels, Paul N. Span
Publikováno v:
Endocrine, 23, 17-24
Endocrine, 23, 1, pp. 17-24
Endocrine, 23, 1, pp. 17-24
Contains fulltext : 58301.pdf (Publisher’s version ) (Open Access) Whether the hexosamine biosynthesis pathway acts as a nutrient-sensing pathway is still unclear. Glucose is directed into this pathway by GFAT. Because the activity of GFAT is tight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c59740b59b6a29d76860fce2889b7a
http://hdl.handle.net/2066/58301
http://hdl.handle.net/2066/58301
Publikováno v:
Diabetes Care, 26, 1637-9
Diabetes Care, 26, 5, pp. 1637-9
Diabetes Care, 26, 5, pp. 1637-9
Type 2 diabetes is characterized by both insulin resistance and an increased cardiovascular mortality (1). Elevated plasma total homocysteine levels are an independent risk factor for cardiovascular disease (2). Also, in patients with type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e9eca5488de816c6a7aba67589dbe
https://doi.org/10.2337/diacare.26.5.1637
https://doi.org/10.2337/diacare.26.5.1637
Autor:
André J. Olthaar, C.G.J. Sweep, Ad R. M. M. Hermus, Baziel G.M. van Engelen, Jos A. Lutterman, Paul N. Span, Marie-Jose J. Pouwels, Jan G. de Jong, Cees J. Tack
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 87, 11, pp. 5179-84
Journal of Clinical Endocrinology and Metabolism, 87, 5179-84
Journal of Clinical Endocrinology and Metabolism, 87, 5179-84
Item does not contain fulltext Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines [UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc)] is an important mechanism by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21425226d058b74a663400246b7fc57
https://pubmed.ncbi.nlm.nih.gov/12414889
https://pubmed.ncbi.nlm.nih.gov/12414889