Výsledky vyhledávání - "Marie-Jose J. Pouwels"

Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue

Autor: André J. Olthaar, Frank C. Huvers, Ad R. M. M. Hermus, Jos A. Lutterman, Paul N. Span, Marie-Jose J. Pouwels, Cees J. Tack, C.G.J. Sweep

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 89, 10, pp. 5132-7
Journal of Clinical Endocrinology and Metabolism, 89, 5132-7

Contains fulltext : 59311.pdf (Publisher’s version ) (Open Access) It has been proposed that the hexosamine pathway acts as a nutrient-sensing pathway, protecting the cell against abundant fuel supply, and that accumulation of hexosamines represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c47613f1dd2e13f35a75181fec56c
https://doi.org/10.1210/jc.2004-0291

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Treatment with intravenous insulin followed by continuous subcutaneous insulin infusion improves glycaemic control in severely resistant Type 2 diabetic patients

Autor: Jos A. Lutterman, C.J.J. Tack, A. R. M. M. Hermus, Marie-Jose J. Pouwels

Publikováno v: Diabetic Medicine, 20, 76-9
Diabetic Medicine, 20, 1, pp. 76-9

Item does not contain fulltext AIMS: Despite high-dose s.c. insulin therapy, some Type 2 diabetes mellitus (DM) patients remain in poor metabolic control. We investigated whether a period of euglycaemia using i.v. insulin, followed by continuous subc

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https://doi.org/10.1046/j.1464-5491.2003.00848.x

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Short-Term Glucosamine Infusion Does Not Affect Insulin Sensitivity in Humans1

Autor: Marie-Jose J. Pouwels, Cees J. Tack, Paul N. Span, Jos A. Lutterman, Paul Smits, Judith R. Jacobs

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:2099-2103

Overactivity of the hexosamine biosynthetic pathway may underlie hyperglycemia-associated insulin resistance, but to date human studies are lacking. Hexosamine pathway activation can be mimicked by glucosamine (GlcN). In the present placebo-controlle

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https://doi.org/10.1210/jcem.86.5.7470

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Assay for Hexosamine Pathway Intermediates (Uridine Diphosphate-N-Acetyl Amino Sugars) in Small Samples of Human Muscle Tissue

Autor: C.G.J. Sweep, Ad R. M. M. Hermus, Remko R. Bosch, Marie-Jose J. Pouwels, Paul N. Span, André J. Olthaar

Publikováno v: Clinical Chemistry. 47:944-946

It has been suggested that the hexosamine biosynthetic pathway is involved in the pathogenesis of insulin resistance in patients with type 2 diabetes mellitus because the activity of the rate-limiting enzyme of this pathway, glutamine:fructose-6-phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c9c01a940648d01658bc34b00eaa59a
https://doi.org/10.1093/clinchem/47.5.944

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Hexosamines are unlikely to function as a nutrient-sensor in 3T3-L1 adipocytes: a comparison of UDP-hexosamine levels after increased glucose flux and glucosamine treatment

Autor: Remko R. Bosch, Cees J. Tack, André J. Olthaar, C.G.J. Sweep, Ad R. M. M. Hermus, Marie-Jose J. Pouwels, Paul N. Span

Publikováno v: Endocrine, 23, 17-24
Endocrine, 23, 1, pp. 17-24

Contains fulltext : 58301.pdf (Publisher’s version ) (Open Access) Whether the hexosamine biosynthesis pathway acts as a nutrient-sensing pathway is still unclear. Glucose is directed into this pathway by GFAT. Because the activity of GFAT is tight

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http://hdl.handle.net/2066/58301

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Improved insulin sensitivity and metabolic control in type 2 diabetes does not influence plasma homocysteine

Autor: Henk J. Blom, Cees J. Tack, Marie-Jose J. Pouwels, Ad R. M. M. Hermus, Martin den Heijer

Publikováno v: Diabetes Care, 26, 1637-9
Diabetes Care, 26, 5, pp. 1637-9

Type 2 diabetes is characterized by both insulin resistance and an increased cardiovascular mortality (1). Elevated plasma total homocysteine levels are an independent risk factor for cardiovascular disease (2). Also, in patients with type 2 diabetes

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https://doi.org/10.2337/diacare.26.5.1637

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Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 diabetes

Autor: André J. Olthaar, C.G.J. Sweep, Ad R. M. M. Hermus, Baziel G.M. van Engelen, Jos A. Lutterman, Paul N. Span, Marie-Jose J. Pouwels, Jan G. de Jong, Cees J. Tack

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 87, 11, pp. 5179-84
Journal of Clinical Endocrinology and Metabolism, 87, 5179-84

Item does not contain fulltext Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines [UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc)] is an important mechanism by w

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https://pubmed.ncbi.nlm.nih.gov/12414889

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